RELA proto-oncogene, NF-kB subunit (Q4047839)

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mammalian protein found in Homo sapiens
  • nuclear factor NF-kappa-B p65 subunit
  • NF-kappa-B transcription factor p65
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
  • NF-kappa-B p65delta3
  • transcription factor p65
  • RELA
  • v-rel avian reticuloendotheliosis viral oncogene homolog A
  • v-rel reticuloendotheliosis viral oncogene homolog A
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Language Label Description Also known as
English
RELA proto-oncogene, NF-kB subunit
mammalian protein found in Homo sapiens
  • nuclear factor NF-kappa-B p65 subunit
  • NF-kappa-B transcription factor p65
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
  • NF-kappa-B p65delta3
  • transcription factor p65
  • RELA
  • v-rel avian reticuloendotheliosis viral oncogene homolog A
  • v-rel reticuloendotheliosis viral oncogene homolog A

Statements

molecular function
protein binding
determination method
IPI
92 references
retrieved
8 April 2019
stated in
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
A novel LZAP-binding protein, NLBP, inhibits cell invasion
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Fas-associated Factor-1 Inhibits Nuclear Factor-κB (NF-κB) Activity by Interfering with Nuclear Translocation of the RelA (p65) Subunit of NF-κB
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel protein from glial cells based on its ability to interact with NF‐κB subunitsr
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Copine-I represses NF-kappaB transcription by endoproteolysis of p65
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
COMMD proteins, a novel family of structural and functional homologs of MURR1
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB activation upregulates fibroblast growth factor 8 expression in prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3 interacts with the NF-κB inhibitor IκBα
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-α-induced NF-κB activation by interacting with p65/RelA and p50/NF-κB1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
IRF5 is required for late-phase TNF secretion by human dendritic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The structure and interactions of the proline-rich domain of ASPP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB and estrogen receptor alpha interactions: Differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Protein phosphatase 2A interacts with and directly dephosphorylates RelA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Structure of an IkappaBalpha/NF-kappaB complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of NF-kappaB activity through lysine monomethylation of p65.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Myocardin inhibits cellular proliferation by inhibiting NF-kappaB(p65)-dependent cell cycle progression.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Caspase-3 cleaved p65 fragment dampens NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
COMMD proteins, a novel family of structural and functional homologs of MURR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Profiling cellular protein complexes by proximity ligation with dual tag microarray readout
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
retrieved
8 April 2019
stated in
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IPI
DNA binding
determination method
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Copine-I represses NF-kappaB transcription by endoproteolysis of p65
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
RNA polymerase II transcription regulatory region sequence-specific DNA binding
determination method
IDA
IEA
IMP
6 references
retrieved
16 July 2018
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
16 July 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
16 July 2018
stated in
Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
16 July 2018
stated in
α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
16 July 2018
stated in
NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
16 July 2018
stated in
Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
RNA polymerase II transcription regulatory region sequence-specific DNA binding
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IBA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method
IBA
IDA
IEA
ISA
ISM
NAS
6 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
ISM
retrieved
8 April 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
ISA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IBA
DNA-binding transcription activator activity, RNA polymerase II-specific
determination method
IDA
IMP
5 references
retrieved
8 April 2019
stated in
p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
cell component
cytoplasm
determination method
IDA
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
I kappa B: a specific inhibitor of the NF-kappa B transcription factor
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
nucleus
determination method
IDA
IEA
IMP
16 references
retrieved
8 April 2019
stated in
Structural and functional properties of the N transcriptional activation domain of thyroid transcription factor-1: similarities with the acidic activation domains
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Copine-I represses NF-kappaB transcription by endoproteolysis of p65
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
I kappa B: a specific inhibitor of the NF-kappa B transcription factor
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
α-Actinin 4 potentiates nuclear factor κ-light-chain-enhancer of activated B-cell (NF-κB) activity in podocytes independent of its cytoplasmic actin binding function
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IMP
6 references
retrieved
16 July 2018
stated in
Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
16 July 2018
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
16 July 2018
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
16 July 2018
stated in
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
16 July 2018
stated in
Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
16 July 2018
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
positive regulation of NF-kappaB transcription factor activity
determination method
IDA
IEA
IGI
IMP
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
TAS
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IEA
retrieved
8 April 2019
stated in
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IMP
9 references
retrieved
1 January 2018
stated in
Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
1 January 2018
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
1 January 2018
stated in
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
1 January 2018
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
1 January 2018
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
1 January 2018
stated in
Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
1 January 2018
stated in
NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
1 January 2018
stated in
Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04206&geneProductId=UniProtKB:Q04206
determination method
IBA
positive regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IGI
IMP
11 references
retrieved
8 April 2019
stated in
Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
MicroRNA-181b regulates endotoxin tolerance by targeting IL-6 in macrophage RAW264.7 cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IMP
retrieved
8 April 2019
stated in
miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB.
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IGI
retrieved
8 April 2019
stated in
The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q04206
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-κB-mediated way in neuronal cells
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04206
determination method
IBA
Gene Atlas image
PBB GE RELA 201783 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Ensembl protein ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q4047839&oldid=2022904981"