Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. (Q39878778)

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1 November 2019

title

Effect of the E4 region on the persistence of transgene expression from adenovirus vectors (English)

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1 November 2019

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Armentano D

1

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1 November 2019

Zabner J

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1 November 2019

Sacks C

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1 November 2019

Sookdeo CC

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1 November 2019

Smith MP

5

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1 November 2019

St George JA

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1 November 2019

Wadsworth SC

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1 November 2019

Smith AE

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1 November 2019

Gregory RJ

9

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1 November 2019

publication date

1 March 1997

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1 November 2019

language of work or name

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1 November 2019

volume

71

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1 November 2019

issue

3

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1 November 2019

page(s)

2408-2416

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Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo

1 November 2019

cites work

1 reference

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Molecular characterization of replication-competent variants of adenovirus vectors and genome modifications to prevent their occurrence

22 September 2017

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Development of a complementing cell line and a system for construction of adenovirus vectors with E1 and E2a deleted

22 September 2017

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Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis

22 September 2017

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Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy

22 September 2017

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Lack of persistence of E1- recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs

22 September 2017

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The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice

22 September 2017

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Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit

22 September 2017

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Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.

22 September 2017

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Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy

22 September 2017

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Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

22 September 2017

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Common control of the heat shock gene and early adenovirus genes: evidence for a cellular E1A-like activity

22 September 2017

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Development of adenovirus vectors for the expression of heterologous genes

22 September 2017

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Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

22 September 2017

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The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA.

22 September 2017

1 reference

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

22 September 2017

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Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1

22 September 2017

1 reference

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NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A

22 September 2017

1 reference

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Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors

22 September 2017

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High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study

25 September 2017

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Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

25 September 2017

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Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.

25 September 2017

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A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions

25 September 2017

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Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutants

25 September 2017

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Characterization of an adenovirus gene transfer vector containing an E4 deletion

25 September 2017

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Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer

25 September 2017

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Adenovirus early region 4 and viral DNA synthesis

15 June 2018

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Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a.

15 June 2018

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Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration

15 June 2018

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15 June 2018

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Gene Therapy for Hemophilia B: Host Immunosuppression Prolongs the Therapeutic Effect of Adenovirus-Mediated Factor IX Expression

20 August 2018

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Transfer of the CFTR Gene to the Lung of Nonhuman Primates with E1-Deleted, E2a-Defective Recombinant Adenoviruses: A Preclinical Toxicology Study

20 August 2018

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Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

20 August 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/9032378