insulin (Q7240673)

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mammalian protein found in Homo sapiens

INS
insulin (prepro)
insulin(1-110)
INS(1-110)
human preproinsulin
preproinsulin
proinsulin
Insulin

Language	Label	Description	Also known as
English	insulin	mammalian protein found in Homo sapiens	INS insulin (prepro) insulin(1-110) INS(1-110) human preproinsulin preproinsulin proinsulin Insulin

Statements

protein precursor

0 references

1 reference

18 December 2019

UniProt protein ID

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01308

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin-like superfamily

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01308

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin-like domain, protein family

1 reference

based on heuristic

deduced from protein domain / family association

Insulin, conserved site, protein family

1 reference

based on heuristic

deduced from protein domain / family association

1 reference

18 December 2019

UniProt protein ID

1 reference

18 December 2019

UniProt protein ID

molecular function

insulin receptor binding

determination method

3 references

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

identical protein binding

determination method

5 references

8 April 2019

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Structural features of proinsulin C-peptide oligomeric and amyloid states

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Peptides that form β-sheets on hydrophobic surfaces accelerate surface-induced insulin amyloidal aggregation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Amino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrils

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

protease binding

determination method

1 reference

8 April 2019

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

insulin-like growth factor receptor binding

determination method

1 reference

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

protein binding

determination method

4 references

8 April 2019

Megalin is an endocytic receptor for insulin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

How insulin engages its primary binding site on the insulin receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Inhibition of insulin receptor activation by insulin-like growth factor binding proteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

hormone activity

determination method

5 references

8 April 2019

Impaired binding of insulin to erythrocyte membrane receptor and the activation of nitric oxide synthase by the hormone in human breast cancer

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

A structurally abnormal insulin causing human diabetes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

insulin-like growth factor receptor binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

determination method

endoplasmic reticulum lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

transport vesicle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

secretory granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

endoplasmic reticulum-Golgi intermediate compartment membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

extracellular region

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

determination method

biological process

negative regulation of NAD(P)H oxidase activity

determination method

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of DNA replication

determination method

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

determination method

positive regulation of MAPK cascade

determination method

2 references

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of brown fat cell differentiation

determination method

1 reference

8 April 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of cell differentiation

determination method

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

9 May 2017

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

determination method

positive regulation of respiratory burst

determination method

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of cytokine secretion

determination method

1 reference

8 April 2019

Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of phosphatidylinositol 3-kinase signaling

determination method

1 reference

8 April 2019

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of protein oligomerization

determination method

1 reference

8 April 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of respiratory burst involved in inflammatory response

determination method

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of nitric oxide biosynthetic process

determination method

1 reference

9 May 2017

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

determination method

positive regulation of nitric-oxide synthase activity

determination method

1 reference

8 April 2019

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of protein autophosphorylation

determination method

1 reference

8 April 2019

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

activation of protein kinase B activity

determination method

1 reference

8 April 2019

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

8 April 2019

Effects of insulin on wound healing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of mitotic nuclear division

determination method

negative regulation of feeding behavior

determination method

1 reference

8 April 2019

Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

cellular protein metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of peptide hormone secretion

determination method

1 reference

8 April 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of protein catabolic process

determination method

1 reference

8 April 2019

Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of cell migration

determination method

1 reference

8 April 2019

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

acute-phase response

determination method

1 reference

8 April 2019

Insulin decreases hepatic acute phase protein levels in severely burned children

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

regulation of protein secretion

determination method

1 reference

8 April 2019

Insulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of glycogen biosynthetic process

determination method

1 reference

8 April 2019

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

G-protein coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

regulation of cellular amino acid metabolic process

determination method

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

determination method

1 reference

8 April 2019

Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

ER to Golgi vesicle-mediated transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of cell growth

determination method

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of glycogen catabolic process

determination method

1 reference

8 April 2019

A structurally abnormal insulin causing human diabetes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of insulin receptor signaling pathway

determination method

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

determination method

negative regulation of acute inflammatory response

determination method

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of protein secretion

determination method

1 reference

8 April 2019

Insulin decreases hepatic acute phase protein levels in severely burned children

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2017

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

determination method

glucose homeostasis

determination method

1 reference

8 April 2019

A structurally abnormal insulin causing human diabetes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of cell proliferation

determination method

fatty acid homeostasis

determination method

1 reference

8 April 2019

Glucagon regulation of plasma ketone body concentration in human diabetes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of cellular protein metabolic process

determination method

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

regulation of transmembrane transporter activity

determination method

1 reference

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of gluconeogenesis

determination method

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of fatty acid metabolic process

determination method

1 reference

8 April 2019

Glucagon regulation of plasma ketone body concentration in human diabetes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

regulation of protein localization

determination method

1 reference

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of lipid biosynthetic process

determination method

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of proteolysis

determination method

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

alpha-beta T cell activation

determination method

1 reference

8 April 2019

Bovine and human insulin activate CD8+-autoreactive CTL expressing both type 1 and type 2 cytokines in C57BL/6 mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of protein localization to nucleus

determination method

1 reference

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of glucose import

determination method

1 reference

9 May 2017

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of blood vessel diameter

determination method

1 reference

8 April 2019

Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of blood vessel diameter

determination method

1 reference

8 April 2019

Insulin impairs endothelium-dependent vasodilation independent of insulin sensitivity or lipid profile

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of nitric oxide mediated signal transduction

determination method

positive regulation of glucose import

determination method

3 references

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Insulin and nitric oxide stimulates glucose transport in human placenta

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of insulin receptor signaling pathway

determination method

3 references

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Insulin and nitric oxide stimulates glucose transport in human placenta

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

8 April 2019

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

regulation of synaptic plasticity

determination method

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

determination method

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of long-term synaptic potentiation

determination method

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

positive regulation of dendritic spine maintenance

determination method

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

regulation of protein localization to plasma membrane

determination method

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

negative regulation of reactive oxygen species biosynthetic process

determination method

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

neuron projection maintenance

determination method

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

determination method

response to L-arginine

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

determination method

signal transduction

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

determination method

Gene Atlas Image

PBB GE INS 206598 at fs.png
732 × 530; 8 KB

0 references

subject has role

anti-diabetic medication

1 reference

Medical Subject Headings

MeSH descriptor ID

15 March 2018

2937.12.00

0 references

NCI Thesaurus ID

C65922

1 reference

Unique Ingredient Identifier

14 February 2018

https://identifiers.org/reactome:R-HSA-264998

1 reference

24 June 2018

https://identifiers.org/reactome:R-HSA-77385

1 reference

25 June 2018

0 references

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01308

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01308

0 references

Commons gallery

Insulin

0 references

Commons category

Insulin

0 references

Identifiers

Brockhaus Enzyklopädie online ID

0 references

Ensembl protein ID

ENSP00000250971

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000250971

ENSP00000370731

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370731

ENSP00000380432

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000380432

ENSP00000408400

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000408400

ENSP00000424008

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424008

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name