Insulin (Q39798)

English

title

Insulin Regular (English)

17 November 2015

1 reference

English

title

Insulin Regular (English)

17 November 2015

1 reference

20 December 2017

1 reference

27 February 2018

1 reference

InterPro Release 66.0

http://www.ebi.ac.uk/interpro/protein/P01308

Insulin-like superfamily

1 reference

stated in

InterPro Release 66.0

http://www.ebi.ac.uk/interpro/protein/P01308

image

InsulinHexamer.jpg380 × 398; 39 KB

0 references

mass

5,805.644359±0 atomic mass unit

1 reference

Biohulin (English)

19 September 2016

C₂₅₇H₃₈₃N₆₅O₇₇S₆

1 reference

Biohulin (English)

19 September 2016

1 reference

EMEA/H/C/000427

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000427/human_med_000625.jsp

22 March 2017

Exubera

1 reference

EMEA/H/C/000588

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000588/human_med_000782.jsp

22 March 2017

Insulatard

1 reference

EMEA/H/C/000441

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000441/human_med_000839.jsp

22 March 2017

Insulin Human Winthrop

1 reference

EMEA/H/C/000761

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000761/human_med_000840.jsp

22 March 2017

Insuman

1 reference

EMEA/H/C/000201

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000201/human_med_000841.jsp

22 March 2017

Mixtard

1 reference

EMEA/H/C/000428

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000428/human_med_000906.jsp

22 March 2017

Monotard

1 reference

EMEA/H/C/000440

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000440/human_med_000909.jsp

22 March 2017

Protaphane

1 reference

EMEA/H/C/000442

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000442/human_med_000998.jsp

22 March 2017

Solumarv

1 reference

EMEA/H/C/003858

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003858/human_med_001942.jsp

22 March 2017

Ultratard

1 reference

EMEA/H/C/000439

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000439/human_med_001121.jsp

22 March 2017

Velosulin

1 reference

EMEA/H/C/000423

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000423/human_med_001132.jsp

22 March 2017

1 reference

14 February 2018

1 reference

14 February 2018

1 reference

20 December 2017

1 reference

20 December 2017

insulin receptor binding

3 references

9 May 2017

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

identical protein binding

4 references

9 May 2017

Peptides that form β-sheets on hydrophobic surfaces accelerate surface-induced insulin amyloidal aggregation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

Structural features of proinsulin C-peptide oligomeric and amyloid states

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

Amino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrils

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

insulin-like growth factor receptor binding

IPI

1 reference

9 May 2017

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

5 references

9 May 2017

Impaired binding of insulin to erythrocyte membrane receptor and the activation of nitric oxide synthase by the hormone in human breast cancer

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

endoplasmic reticulum lumen

IC

cell component

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

secretory granule lumen

1 reference

9 May 2017

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

endoplasmic reticulum-Golgi intermediate compartment membrane

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

4 references

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

9 May 2017

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of NAD(P)H oxidase activity

biological process

1 reference

9 May 2017

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of DNA replication

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of MAPK cascade

positive regulation of brown fat cell differentiation

1 reference

9 May 2017

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of cell differentiation

1 reference

9 May 2017

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of respiratory burst

1 reference

9 May 2017

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of cytokine secretion

1 reference

9 May 2017

Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of protein oligomerization

1 reference

9 May 2017

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of NF-kappaB transcription factor activity

1 reference

9 May 2017

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of respiratory burst involved in inflammatory response

1 reference

9 May 2017

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of nitric oxide biosynthetic process

IC

1 reference

9 May 2017

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of nitric-oxide synthase activity

1 reference

9 May 2017

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of protein autophosphorylation

1 reference

9 May 2017

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

activation of protein kinase B activity

ISS

1 reference

9 May 2017

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

Effects of insulin on wound healing

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of feeding behavior

1 reference

9 May 2017

Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

cellular protein metabolic process

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of peptide hormone secretion

1 reference

9 May 2017

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of protein catabolic process

1 reference

9 May 2017

Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of cell migration

1 reference

9 May 2017

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

9 May 2017

Insulin decreases hepatic acute phase protein levels in severely burned children

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

regulation of protein secretion

1 reference

9 May 2017

Insulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of glycogen biosynthetic process

1 reference

9 May 2017

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of protein kinase B signaling

1 reference

9 May 2017

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

G-protein coupled receptor signaling pathway

1 reference

9 May 2017

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

regulation of cellular amino acid metabolic process

1 reference

9 May 2017

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

IMP

1 reference

9 May 2017

Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

ER to Golgi vesicle-mediated transport

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of cell growth

1 reference

9 May 2017

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of glycogen catabolic process

1 reference

9 May 2017

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of insulin receptor signaling pathway

IMP

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226