insulin (Q39798)

title

Insulin Regular (English)

17 November 2015

1 reference

maintenance of location in cell

title

Insulin Regular (English)

17 November 2015

2 references

24 June 2018

25 June 2018

0 references

0 references

0 references

0 references

2 references

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin-like superfamily

2 references

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin processing

0 references

Exocytosis of Insulin

0 references

Signaling by Insulin receptor

0 references

Insulin degradation

0 references

Regulation of insulin secretion

0 references

image

InsulinHexamer.jpg
380 × 398; 39 KB

0 references

mass

5,805.644359 atomic mass unit

1 reference

Biohulin (English)

19 September 2016

C₂₅₇H₃₈₃N₆₅O₇₇S₆

1 reference

Biohulin (English)

19 September 2016

1 reference

EMEA/H/C/000427

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000427/human_med_000625.jsp

22 March 2017

Exubera

1 reference

EMEA/H/C/000588

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000588/human_med_000782.jsp

22 March 2017

Insulatard

1 reference

EMEA/H/C/000441

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000441/human_med_000839.jsp

22 March 2017

Insulin Human Winthrop

1 reference

EMEA/H/C/000761

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000761/human_med_000840.jsp

22 March 2017

Insuman

1 reference

EMEA/H/C/000201

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000201/human_med_000841.jsp

22 March 2017

Mixtard

1 reference

EMEA/H/C/000428

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000428/human_med_000906.jsp

22 March 2017

Monotard

1 reference

EMEA/H/C/000440

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000440/human_med_000909.jsp

22 March 2017

Protaphane

1 reference

EMEA/H/C/000442

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000442/human_med_000998.jsp

22 March 2017

Solumarv

1 reference

EMEA/H/C/003858

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003858/human_med_001942.jsp

22 March 2017

Ultratard

1 reference

EMEA/H/C/000439

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000439/human_med_001121.jsp

22 March 2017

Velosulin

1 reference

EMEA/H/C/000423

http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000423/human_med_001132.jsp

22 March 2017

1 reference

14 February 2018

1 reference

14 February 2018

4 references

5 December 2018

17 September 2016

24 June 2018

25 June 2018

medical condition treated

Type one diabetes mellitus

1 reference

Drug Indications Extracted from FAERS

maturity-onset diabetes of the young type 2

2 October 2018

1 reference

Drug Indications Extracted from FAERS

2 October 2018

2 references

5 December 2018

20 March 2016

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

molecular function

insulin receptor binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

identical protein binding

5 references

8 April 2019

A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Structural features of proinsulin C-peptide oligomeric and amyloid states

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Peptides that form β-sheets on hydrophobic surfaces accelerate surface-induced insulin amyloidal aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Amino acid sequence determinants in self-assembly of insulin chiral amyloid superstructures: role of C-terminus of B-chain in association of fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

insulin-like growth factor receptor binding

IPI

1 reference

8 April 2019

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

4 references

8 April 2019

Megalin is an endocytic receptor for insulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

How insulin engages its primary binding site on the insulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Inhibition of insulin receptor activation by insulin-like growth factor binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

5 references

8 April 2019

Impaired binding of insulin to erythrocyte membrane receptor and the activation of nitric oxide synthase by the hormone in human breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

insulin-like growth factor receptor binding

IC

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

endoplasmic reticulum lumen

ISS

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

secretory granule lumen

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

endoplasmic reticulum-Golgi intermediate compartment membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

negative regulation of NAD(P)H oxidase activity

ISS

biological process

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of DNA replication

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of MAPK cascade

2 references

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of brown fat cell differentiation

1 reference

8 April 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cell differentiation

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

9 May 2017

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of respiratory burst

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cytokine secretion

1 reference

8 April 2019

Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of protein oligomerization

1 reference

8 April 2019

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of respiratory burst involved in inflammatory response

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of nitric oxide biosynthetic process

IC

1 reference

9 May 2017

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of nitric-oxide synthase activity

1 reference

8 April 2019

Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of protein autophosphorylation

1 reference

8 April 2019

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

activation of protein kinase B activity

ISS

1 reference

8 April 2019

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

Effects of insulin on wound healing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of mitotic nuclear division

negative regulation of feeding behavior

1 reference

8 April 2019

Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

cellular protein metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of peptide hormone secretion

1 reference

8 April 2019

Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of protein catabolic process

1 reference

8 April 2019

Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cell migration

1 reference

8 April 2019

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

Insulin decreases hepatic acute phase protein levels in severely burned children

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of protein secretion

1 reference

8 April 2019

Insulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of glycogen biosynthetic process

1 reference

8 April 2019

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of protein kinase B signaling

1 reference

8 April 2019

Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

G-protein coupled receptor signaling pathway

1 reference

8 April 2019

Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of cellular amino acid metabolic process

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

ER to Golgi vesicle-mediated transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cell growth

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of glycogen catabolic process

1 reference

8 April 2019

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of insulin receptor signaling pathway

1 reference

9 May 2017

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

negative regulation of acute inflammatory response

1 reference

8 April 2019

Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of protein secretion

1 reference

8 April 2019

Insulin decreases hepatic acute phase protein levels in severely burned children

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2017

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

1 reference

8 April 2019

A structurally abnormal insulin causing human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cell proliferation

Glucagon regulation of plasma ketone body concentration in human diabetes

fatty acid homeostasis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of cellular protein metabolic process

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of transmembrane transporter activity

1 reference

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of gluconeogenesis

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of fatty acid metabolic process

1 reference

8 April 2019

Glucagon regulation of plasma ketone body concentration in human diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of protein localization

1 reference

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of transcription, DNA-templated

1 reference

8 April 2019

Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of lipid biosynthetic process

1 reference

8 April 2019

Insulin signalling and the regulation of glucose and lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of proteolysis

1 reference

8 April 2019

Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

alpha-beta T cell activation

1 reference

8 April 2019

Bovine and human insulin activate CD8+-autoreactive CTL expressing both type 1 and type 2 cytokines in C57BL/6 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of protein localization to nucleus

1 reference

8 April 2019

A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of glucose import

1 reference

9 May 2017

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308

positive regulation of gene expression

1 reference

8 April 2019

Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of blood vessel diameter

1 reference

8 April 2019

Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of blood vessel diameter

1 reference

8 April 2019

Insulin impairs endothelium-dependent vasodilation independent of insulin sensitivity or lipid profile

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of nitric oxide mediated signal transduction

positive regulation of glucose import

3 references

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin and nitric oxide stimulates glucose transport in human placenta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of insulin receptor signaling pathway

3 references

8 April 2019

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin and nitric oxide stimulates glucose transport in human placenta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

8 April 2019

Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of synaptic plasticity

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of long-term synaptic potentiation

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

positive regulation of dendritic spine maintenance

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

regulation of protein localization to plasma membrane

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

negative regulation of reactive oxygen species biosynthetic process

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

neuron projection maintenance

1 reference

8 April 2019

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

response to L-arginine

1 reference

9 May 2019

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5

IEA

Gene Atlas Image

PBB GE INS 206598 at fs.png
732 × 530; 8 KB

0 references

subject has role

anti-diabetic medication

1 reference

imported from Wikimedia project

Medical Subject Headings

15 March 2018

Insulin

0 references

Commons category

Insulin

0 references

topic's main category

Category:Insulin

1 reference

Swedish Wikipedia

MCN code

2937.12.00

0 references

NCI Thesaurus ID

C65922

1 reference

Unique Ingredient Identifier

14 February 2018

https://identifiers.org/reactome:R-HSA-264998

1 reference

24 June 2018

https://identifiers.org/reactome:R-HSA-77385

1 reference

25 June 2018

2 references

http://www.ebi.ac.uk/interpro/protein/C9JNR5

Insulin, conserved site

1 reference

disulfide crosslinked residues

1 reference

0 references

0 references

0 references

Identifiers

1 reference

5 December 2018

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016