Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition (Q39747969)

14 September 2017

title

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition (English)

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14 September 2017

6

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14 September 2017

A Lindqvist

2

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author name string

L Macůrek

1

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14 September 2017

O Voets

3

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14 September 2017

J Kool

4

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14 September 2017

H R Vos

5

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14 September 2017

publication date

25 January 2010

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14 September 2017

language of work or name

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14 September 2017

volume

29

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14 September 2017

issue

15

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14 September 2017

page(s)

2281-2291

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DNA damage signalling guards against activated oncogenes and tumour progression

14 September 2017

cites work

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Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

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H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

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A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

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PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

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Activation of multiple DNA repair pathways by sub-nuclear damage induction methods

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

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A role for Saccharomyces cerevisiae histone H2A in DNA repair.

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

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Histone H2A phosphorylation in DNA double-strand break repair

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

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Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

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Wip1-deficient mice are resistant to common cancer genes

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FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry

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A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery

21 January 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

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Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.

21 January 2018

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Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression

21 January 2018

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The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

21 January 2018

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

21 January 2018

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

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PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

21 January 2018

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Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint

21 January 2018

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Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

21 January 2018

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DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

21 January 2018

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21 January 2018

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Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

21 January 2018

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Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break

21 January 2018

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

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Elimination of radiation-induced gamma-H2AX foci in mammalian nucleus can occur by histone exchange

21 January 2018

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

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NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

21 January 2018

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The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

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Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

21 January 2018

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Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.501

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.501

1 reference

14 September 2017

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