Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants (Q39366426)

11 September 2017

Extreme Depletion of PIP3 Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans Mutants (English)

1 reference

Phosphatidylinositol 3-kinase age-1 CELE_B0334.8

11 September 2017

Caenorhabditis elegans

0 references

1 reference

GOA release 2020-03-11

1 reference

Puneet Bharill

1

1 reference

11 September 2017

Srinivas Ayyadevara

series ordinal

2

1 reference

11 September 2017

Ramani Alla

series ordinal

3

1 reference

11 September 2017

Robert J Shmookler Reis

series ordinal

4

1 reference

11 September 2017

28 March 2013

1 reference

11 September 2017

Frontiers in Genetics

1 reference

11 September 2017

4

1 reference

11 September 2017

34

1 reference

describes a project that uses

11 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3610087/fullTextXML

inferred from PubMed Central ID database lookup

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The chemical biology of phosphoinositide 3-kinases

11 September 2017

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11 September 2017

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Phosphoinositides and vesicular membrane traffic

11 September 2017

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Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan

11 September 2017

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Extreme-longevity mutations orchestrate silencing of multiple signaling pathways

11 September 2017

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The mood stabiliser lithium suppresses PIP3 signalling in Dictyostelium and human cells.

11 September 2017

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Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance

11 September 2017

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Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

11 September 2017

1 reference

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Current overview of the role of Akt in cancer studies via applied immunohistochemistry

11 September 2017

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Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells

11 September 2017

1 reference

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Remarkable longevity and stress resistance of nematode PI3K-null mutants

11 September 2017

1 reference

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Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse

11 September 2017

1 reference

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Signalling through Class I PI3Ks in mammalian cells

11 September 2017

1 reference

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Quantitative trait loci define genes and pathways underlying genetic variation in longevity

11 September 2017

1 reference

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Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

11 September 2017

1 reference

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Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry

11 September 2017

1 reference

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Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm

11 September 2017

1 reference

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DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins

11 September 2017

1 reference

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Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms.

11 September 2017

1 reference

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Genetic mapping of quantitative trait loci governing longevity of Caenorhabditis elegans in recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.

11 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

11 September 2017

1 reference

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Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.

11 September 2017

1 reference

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Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.

14 September 2017

1 reference

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Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells

14 September 2017

1 reference

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Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues

14 September 2017

1 reference

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PI3K: downstream AKTion blocks apoptosis

14 September 2017

1 reference

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A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells

25 September 2017

1 reference

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The unc-86 gene product couples cell lineage and cell identity in C. elegans

15 June 2018

1 reference

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The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3'-kinase, in human colon cancer cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610087

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23543623

12 December 2020

inferred from PubMed ID database lookup

Analysis of intact phosphoinositides in biological samples

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23543623

12 December 2020

inferred from PubMed ID database lookup

CpG DNA Activates Survival in Murine Macrophages through TLR9 and the Phosphatidylinositol 3-Kinase-Akt Pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23543623

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.3389/FGENE.2013.00034

1 reference

11 September 2017

1 reference

11 September 2017

1 reference