Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers. (Q38811832)

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scientific article published on 14 October 2016

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English	Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers.	scientific article published on 14 October 2016

Statements

scholarly article

1 reference

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25 March 2020

Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers (English)

1 reference

Europe PubMed Central

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25 March 2020

Hepatitis B virus

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based on heuristic

inferred from title

chronic hepatitis B

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based on heuristic

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pharmacokinetics

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based on heuristic

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RNA interference

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based on heuristic

inferred from title

chronic hepatitis

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based on heuristic

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5

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8

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author name string

Thomas Schluep

1

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Jason Lickliter

2

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James Hamilton

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David L Lewis

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Johnson Yn Lau

6

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25 March 2020

Stephen A Locarnini

7

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Bruce D Given

9

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publication date

12 December 2016

1 reference

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25 March 2020

Clinical pharmacology in drug development

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6

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25 March 2020

350-362

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4

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Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent.

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siRNA and innate immunity

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Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes

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Species-specific inflammatory responses as a primary component for the development of glomerular lesions in mice and monkeys following chronic administration of a second-generation antisense oligonucleotide.

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To "be" or not to "be": that is the question

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PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties

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Natural history of hepatitis B

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Postprandial serum creatinine increase in normal subjects after eating cooked meat

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Identifiers

10.1002/CPDD.318

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