TRAF6 Mediates Suppression of Osteoclastogenesis and Prevention of Ovariectomy-Induced Bone Loss by a Novel Prenylflavonoid. (Q38733018)

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26 March 2020

title

TRAF6 Mediates Suppression of Osteoclastogenesis and Prevention of Ovariectomy-Induced Bone Loss by a Novel Prenylflavonoid (English)

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26 March 2020

5

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26 March 2020

author name string

Ee Min Tan

1

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26 March 2020

Lei Li

2

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26 March 2020

Inthrani Raja Indran

3

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26 March 2020

Nicholas Chew

4

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26 March 2020

publication date

23 February 2017

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Journal of Bone and Mineral Research

26 March 2020

published in

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26 March 2020

volume

32

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26 March 2020

page(s)

846-860

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issue

4

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Osteoporosis: a still increasing prevalence

26 March 2020

cites work

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Perspective. How many women have osteoporosis?

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Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6

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TRAFs in RANK signaling

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TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

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Regulation of NFATc1 in Osteoclast Differentiation

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RANKL-mediated reactive oxygen species pathway that induces long lasting Ca2+ oscillations essential for osteoclastogenesis

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TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways.

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Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis

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A Dietary Medium-Chain Fatty Acid, Decanoic Acid, Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.

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A novel prostate cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen receptor and its splice variants

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Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression.

21 January 2018

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Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation

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Osteoclast differentiation and activation

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Ormeloxifene inhibits osteoclast differentiation in parallel to downregulating RANKL-induced ROS generation and suppressing the activation of ERK and JNK in murine RAW264.7 cells

21 January 2018

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A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

21 January 2018

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NADPH oxidase-derived reactive oxygen species are essential for differentiation of a mouse macrophage cell line (RAW264.7) into osteoclasts

21 January 2018

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Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

21 January 2018

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The regulation of proteasome degradation by multi-ubiquitin chain binding proteins

21 January 2018

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Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops

21 January 2018

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Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells

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Naringenin inhibits human osteoclastogenesis and osteoclastic bone resorption

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The inhibition of RANKL-induced osteoclastogenesis through the suppression of p38 signaling pathway by naringenin and attenuation of titanium-particle-induced osteolysis

21 January 2018

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Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production

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21 January 2018

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Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1.

21 January 2018

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Phytoestrogens directly inhibit TNF-α-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression

21 January 2018

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Requirement for NF-kappaB in osteoclast and B-cell development

21 January 2018

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A 3D scanning confocal imaging method measures pit volume and captures the role of Rac in osteoclast function

21 January 2018

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Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1.

21 January 2018

1 reference

A novel prenylflavone restricts breast cancer cell growth through AhR-mediated destabilization of ERα protein

21 January 2018

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SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses

21 January 2018

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Negative regulation of RANKL-induced osteoclastic differentiation in RAW264.7 Cells by estrogen and phytoestrogens.

21 January 2018

1 reference

Discovery of small molecule CD40-TRAF6 inhibitors

21 January 2018

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Icaritin Attenuates Myocardial Ischemia and Reperfusion Injury Via Anti-Inflammatory and Anti-Oxidative Stress Effects in Rats.

21 January 2018

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Icaritin exhibits anti-inflammatory effects in the mouse peritoneal macrophages and peritonitis model.

21 January 2018

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Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study

21 January 2018

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Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro

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T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

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21 January 2018

Identifiers

DOI

10.1002/JBMR.3031

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26 March 2020

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