Unravelling the human genome-phenome relationship using phenome-wide association studies. (Q38732876)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26875678%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Unravelling the human genome-phenome relationship using phenome-wide association studies (English)

1 reference

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genome-wide association study

7 March 2020

main subject

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author

William S Bush

series ordinal

1

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7 March 2020

Dana Crawford

series ordinal

3

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7 March 2020

author name string

Matthew T Oetjens

series ordinal

2

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7 March 2020

publication date

15 February 2016

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7 March 2020

language of work or name

English

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published in

Nature Reviews Genetics

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7 March 2020

volume

17

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7 March 2020

issue

3

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7 March 2020

page(s)

129-145

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The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association

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Genome-wide "pleiotropy scan" identifies HNF1A region as a novel pancreatic cancer susceptibility locus

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Phenome-wide association studies on a quantitative trait: application to TPMT enzyme activity and thiopurine therapy in pharmacogenomics

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A comparison of phenotype definitions for diabetes mellitus

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Extracting Primary Open-Angle Glaucoma from Electronic Medical Records for Genetic Association Studies

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A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains

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Defining the role of common variation in the genomic and biological architecture of adult human height

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Genetic studies of body mass index yield new insights for obesity biology

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A rigorous algorithm to detect and clean inaccurate adult height records within EHR systems.

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Extraction of echocardiographic data from the electronic medical record is a rapid and efficient method for study of cardiac structure and function

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Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report

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Identifying patient smoking status from medical discharge records

21 January 2018

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Validation of PhenX measures in the personalized medicine research project for use in gene/environment studies

21 January 2018

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Dietary intake in the Personalized Medicine Research Project: a resource for studies of gene-diet interaction

21 January 2018

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Community-level determinants of obesity: harnessing the power of electronic health records for retrospective data analysis

21 January 2018

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Body mass index and the built and social environments in children and adolescents using electronic health records

21 January 2018

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An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus

21 January 2018

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Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus

21 January 2018

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Personal omics profiling reveals dynamic molecular and medical phenotypes

21 January 2018

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Incorporating temporal EHR data in predictive models for risk stratification of renal function deterioration

21 January 2018

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Generalized estimating equations for genome-wide association studies using longitudinal phenotype data.

21 January 2018

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Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols

21 January 2018

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MedEx: a medication information extraction system for clinical narratives.

21 January 2018

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MedXN: an open source medication extraction and normalization tool for clinical text

21 January 2018

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Normalized names for clinical drugs: RxNorm at 6 years

21 January 2018

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Study newsletters, community and ethics advisory boards, and focus group discussions provide ongoing feedback for a large biobank

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Reform of Clinical Research Regulations, Finally

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Ethical, legal, and social implications of incorporating genomic information into electronic health records

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21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG.2015.36

Identifying personal genomes by surname inference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Return of genomic results to research participants: the floor, the ceiling, and the choices in between

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

The NCBI dbGaP database of genotypes and phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

NCBI's Database of Genotypes and Phenotypes: dbGaP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

The PhenX Toolkit: get the most from your measures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Using PhenX measures to identify opportunities for cross-study analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

A unified framework for association analysis with multiple related phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

TATES: efficient multivariate genotype-phenotype analysis for genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

A comparison of multivariate genome-wide association methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

News from the NIH: potential contributions of the behavioral and social sciences to the precision medicine initiative

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

What makes UK Biobank special?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

eMERGEing progress in genomics-the first seven years

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Bringing the Common Rule into the 21st Century

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

A multivariate test of association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Pleiotropy and principal components of heritability combine to increase power for association analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Informed consent: A broken contract

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Planning for US Precision Medicine Initiative underway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Accuracy of administrative coding for type 2 diabetes in children, adolescents, and young adults

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Seeing the forest through the trees: uncovering phenomic complexity through interactive network visualization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Common disorders are quantitative traits

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2015.36

Linkage of the 1999-2008 National Health and Nutrition Examination Surveys to traffic indicators from the National Highway Planning Network

31 March 2020

1 reference

12 December 2020

Development of exposome correlation globes to map out environment-wide associations

1 reference

12 December 2020

TESTING POPULATION-SPECIFIC QUANTITATIVE TRAIT ASSOCIATIONS FOR CLINICAL OUTCOME RELEVANCE IN A BIOREPOSITORY LINKED TO ELECTRONIC HEALTH RECORDS: LPA AND MYOCARDIAL INFARCTION IN AFRICAN AMERICANS.

1 reference

12 December 2020

BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge

1 reference

12 December 2020

Strategies for Handling Missing Data in Electronic Health Record Derived Data

1 reference

12 December 2020

Phenotype Information Retrieval for Existing GWAS Studies

1 reference

12 December 2020

Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank

1 reference

12 December 2020

Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci.

1 reference

12 December 2020

Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients

1 reference

12 December 2020

Linkage of the Third National Health and Nutrition Examination Survey to air quality data

1 reference

12 December 2020

Metrics and tools for consistent cohort discovery and financial analyses post-transition to ICD-10-CM

1 reference

12 December 2020