Molecular landscapes of human hematopoietic stem cells in health and leukemia (Q38668304)

5 September 2017

Molecular landscapes of human hematopoietic stem cells in health and leukemia (English)

1 reference

5 September 2017

Cyrille F Dunant

3

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Elisa Laurenti

object named as

Elisa Laurenti

5

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John Dick

object named as

John E Dick

4

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author name string

Aditi Vedi

1

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PubMed ID

26663266

5 September 2017

Antonella Santoro

2

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PubMed ID

26663266

5 September 2017

language of work or name

English

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publication date

11 December 2015

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Annals of the New York Academy of Sciences

5 September 2017

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5 September 2017

1370

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5 September 2017

5-14

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5 September 2017

1

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Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

5 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

The analysis, roles and regulation of quiescence in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Metabolic requirements for the maintenance of self-renewing stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Making sense of hematopoietic stem cell niches

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Hematopoiesis: a human perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Densely interconnected transcriptional circuits control cell states in human hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Transcriptional diversity during lineage commitment of human blood progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Hematopoietic fingerprints: an expression database of stem cells and their progeny

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12981

Transcriptome analysis identifies regulators of hematopoietic stem and progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12981

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12981

Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Load and lock: the molecular mechanisms of B-lymphocyte commitment.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12981

Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNYAS.12981

A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

CDK6 levels regulate quiescence exit in human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Kit regulates HSC engraftment across the human-mouse species barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Long non-coding RNAs control hematopoietic stem cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

The long noncoding RNA Pnky regulates neuronal differentiation of embryonic and postnatal neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Modeling human hematopoietic stem cell biology in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

The ageing haematopoietic stem cell compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Cell intrinsic alterations underlie hematopoietic stem cell aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

DNA methylation dynamics during in vivo differentiation of blood and skin stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Immunogenetics. Chromatin state dynamics during blood formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Stem cell concepts renew cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Cells of origin in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Evolution of the cancer stem cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Stem cell gene expression programs influence clinical outcome in human leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Signatures of mutational processes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Human hemato-lymphoid system mice: current use and future potential for medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

Xenograft models for normal and malignant stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

De novo generation of HSCs from somatic and pluripotent stem cell sources

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12981

21 January 2018

Identifiers

DOI

10.1111/NYAS.12981

1 reference

5 September 2017

1 reference

PubMed ID

26663266