Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins (Q38530632)

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scientific article published on July 2015

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English	Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins	scientific article published on July 2015

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scholarly article

1 reference

Europe PubMed Central

3 September 2017

1 reference

Europe PubMed Central

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins (English)

1 reference

Europe PubMed Central

3 September 2017

author name string

Edmond M Linossi

1

1 reference

Europe PubMed Central

3 September 2017

Sandra E Nicholson

2

1 reference

Europe PubMed Central

3 September 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 July 2015

1 reference

Europe PubMed Central

3 September 2017

Immunological Reviews

1 reference

Europe PubMed Central

3 September 2017

266

1 reference

Europe PubMed Central

3 September 2017

123-133

1 reference

Europe PubMed Central

3 September 2017

1

1 reference

Europe PubMed Central

3 September 2017

Biology and significance of the JAK/STAT signalling pathways

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Janus kinase deregulation in leukemia and lymphoma

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

JAKs and STATs in immunity, immunodeficiency, and cancer

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

A family of cytokine-inducible inhibitors of signalling

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Structure and function of a new STAT-induced STAT inhibitor

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

A new protein containing an SH2 domain that inhibits JAK kinases

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Twenty proteins containing a C-terminal SOCS box form five structural classes

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Evolution of JAK-STAT pathway components: mechanisms and role in immune system development

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS3 negatively regulates IL-6 signaling in vivo

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Genetic reduction of embryonic leukemia-inhibitory factor production rescues placentation in SOCS3-null embryos but does not prevent inflammatory disease

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The biology and mechanism of action of suppressor of cytokine signaling 3

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS3 regulates the plasticity of gp130 signaling

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Interleukin-6 signalling: more than Jaks and STATs

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Negative regulation of FAK signaling by SOCS proteins

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Identification of STAT3 as a specific substrate of breast tumor kinase

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Intrinsically disordered proteins and intrinsically disordered protein regions

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Intrinsically unstructured proteins and their functions

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Drosophila SOCS Proteins

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Function and regulation of cullin-RING ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The complexity of recognition of ubiquitinated substrates by the 26S proteasome

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

RING domain E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The SOCS box-adapting proteins for ubiquitination and proteasomal degradation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Nuclear trafficking of STAT proteins visualized by live cell imaging.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

CRISPR-Cas systems for editing, regulating and targeting genomes

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Identification of a nuclear localization signal in suppressor of cytokine signaling 1.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Structural and functional analysis of a nuclear localization signal in SOCS1.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Development of hydrocephalus in mice lacking SOCS7.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma.

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Intracellular delivery of a cell-penetrating SOCS1 that targets IFN-gamma signaling

1 reference

https://api.crossref.org/works/10.1111%2FIMR.12305

21 January 2018

Identifiers

10.1111/IMR.12305

1 reference

Europe PubMed Central

3 September 2017

1 reference

Europe PubMed Central

3 September 2017

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