Thyroid hormone transporters--functions and clinical implications (Q38460012)

3 September 2017

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title

Thyroid hormone transporters--functions and clinical implications (English)

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PubMed ID

25942657

Erratum: Thyroid hormone transporters—functions and clinical implications

3 September 2017

corrigendum / erratum

Erratum: Thyroid hormone transporters—functions and clinical implications

1

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Beatriz Morte

3

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Ana Guadaño-Ferraz

object named as

Ana Guadaño-Ferraz

2

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Juan Bernal

object named as

Juan Bernal

1

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publication date

5 May 2015

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Nature Reviews Endocrinology

3 September 2017

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3 September 2017

11

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3 September 2017

406-417

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3 September 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrendo.2015.66

3 September 2017

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cites work

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Molecular aspects of thyroid hormone actions

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Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling

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Plasma membrane transport of thyroid hormones and its role in thyroid hormone metabolism and bioavailability

21 January 2018

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A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene

21 January 2018

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Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

A novel transmembrane transporter encoded by the XPCT gene in Xq13.2

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Thyroid hormone transporters

21 January 2018

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Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats

21 January 2018

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Stereospecific transport of triiodothyronine from plasma to cytosol and from cytosol to nucleus in rat liver, kidney, brain, and heart

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Primary and secondary thyroid hormone transporters

21 January 2018

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An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

21 January 2018

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The monocarboxylate transporter family--Structure and functional characterization

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Study of the transport of thyroid hormone by transporters of the SLC10 family

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Thyroid hormone transport by 4F2hc-IU12 heterodimers expressed in Xenopus oocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Selective expression of the large neutral amino acid transporter at the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The superfamily of organic anion transporting polypeptides

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The expression and function of organic anion transporting polypeptides in normal tissues and in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Cellular entry of thyroid hormones by organic anion transporting polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Minireview: thyroid hormone transporters: the knowns and the unknowns

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

X-linked MCT8 gene mutations: characterization of the pediatric neurologic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The MCT8 thyroid hormone transporter and Allan-Herndon-Dudley syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

A novel monocarboxylate transporter 8 gene mutation as a cause of severe neonatal hypotonia and developmental delay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Allan-Herndon-Dudley syndrome (AHDS) in two consecutive generations caused by a missense MCT8 gene mutation. Phenotypic variability with the presence of normal serum T3 levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Unexpected peripheral markers of thyroid function in a patient with a novel mutation of the MCT8 thyroid hormone transporter gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

A novel mutation in the monocarboxylate transporter 8 gene in a boy with putamen lesions and low free T4 levels in cerebrospinal fluid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Clinical phenotype and endocrinological investigations in a patient with a mutation in the MCT8 thyroid hormone transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Distinct roles of deiodinases on the phenotype of Mct8 defect: a comparison of eight different mouse genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Deiodinase activities in thyroids and tissues of iodine-deficient female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Regulation of thyroid hormone metabolism during fetal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Consequences of monocarboxylate transporter 8 deficiency for renal transport and metabolism of thyroid hormones in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Mct8-deficient mice have increased energy expenditure and reduced fat mass that is abrogated by normalization of serum T3 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Changes in thyroid status during perinatal development of MCT8-deficient male mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Type 3 deiodinase is critical for the maturation and function of the thyroid axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Allan-Herndon-Dudley syndrome (AHDS) caused by a novel SLC16A2 gene mutation showing severe neurologic features and unexpectedly low TRH-stimulated serum TSH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Novel neuroanatomical pathways for thyroid hormone action in the human anterior pituitary.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Carrier-Mediated Transport of Thyroid Hormones through the Rat Blood-Brain Barrier: Primary Role of Albumin-Bound Hormone*

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Importance of monocarboxylate transporter 8 for the blood-brain barrier-dependent availability of 3,5,3'-triiodo-L-thyronine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Thyroxine-thyroid hormone receptor interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Thyroid hormone-regulated mouse cerebral cortex genes are differentially dependent on the source of the hormone: a study in monocarboxylate transporter-8- and deiodinase-2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Lack of action of exogenously administered T3 on the fetal rat brain despite expression of the monocarboxylate transporter 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Expression profile and thyroid hormone responsiveness of transporters and deiodinases in early embryonic chicken brain development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Transport of iodothyronines from bloodstream to brain: contributions by blood:brain and choroid plexus:cerebrospinal fluid barriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

White matter abnormalities and dystonic motor disorder associated with mutations in the SLC16A2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

X-linked paroxysmal dyskinesia and severe global retardation caused by defective MCT8 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Increased oxidative metabolism and neurotransmitter cycling in the brain of mice lacking the thyroid hormone transporter SLC16A2 (MCT8)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The involvement of thyroid hormones and cortisol in the osmotic acclimation of Solea senegalensis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Zebrafish as a model for monocarboxyl transporter 8-deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Mutations of the thyroid hormone transporter MCT8 cause prenatal brain damage and persistent hypomyelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Distribution of parvalbumin immunoreactivity in the neocortex of hypothyroid adult rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

1H magnetic resonance spectroscopy in monocarboxylate transporter 8 gene deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Pelizaeus-Merzbacher-Like disease presentation of MCT8 mutated male subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Delayed myelination is not a constant feature of Allan-Herndon-Dudley syndrome: report of a new case and review of the literature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Genotype-phenotype relationship in patients with mutations in thyroid hormone transporter MCT8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Identification, functional analysis, prevalence and treatment of monocarboxylate transporter 8 (MCT8) mutations in a cohort of adult patients with mental retardation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Mutations in MCT8 in patients with Allan-Herndon-Dudley-syndrome affecting its cellular distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Magnetic resonance imaging of brain and the neuromotor disorder in endemic cretinism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The neurology of endemic cretinism. A study of two endemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Identification of Thyroid Hormone Transporters in Humans: Different Molecules Are Involved in a Tissue-Specific Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

The development of the anterior commissure in normal and hypothyroid rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Plasma Membrane Transport of Thyroid Hormones and Its Role in Thyroid Hormone Metabolism and Bioavailability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Thyroid hormone transport by the heterodimeric human system L amino acid transporter.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Development of the choroid plexus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

3,′,′-Triiodothyronine (Reverse T3) in Human Cerebrospinal Fluid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Identification and functional characterization of zebrafish solute carrier Slc16a2 (Mct8) as a thyroid hormone membrane transporter.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Ontogenesis of the nuclear 3,5,3'-triiodothyronine receptor in the human fetal brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.66

Analysis of thyroid hormone-dependent genes in the brain by in situ hybridization

31 March 2020

1 reference

12 December 2020

Role of the System L permease LAT1 in amino acid and iodothyronine transport in placenta

1 reference

12 December 2020

Neurological signs in congenital iodine-deficiency disorder (endemic cretinism).

1 reference

12 December 2020

Expression pattern of thyroid hormone transporters in the postnatal mouse brain

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2015.66

1 reference

3 September 2017

1 reference

PubMed ID

25942657