Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages (Q38028343)

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8 February 2020

title

Atypical ubiquitylation - the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages (English)

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8 February 2020

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages (English)

1 reference

7 January 2025

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7 January 2025

publication date

23 July 2012

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8 February 2020

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22820888

http://www.nature.com/articles/nrm3394.pdf

7 January 2025

work available at URL

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http://www.nature.com/articles/nrm3394

7 January 2025

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Nature Reviews Molecular Cell Biology

7 January 2025

published in

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8 February 2020

volume

13

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8 February 2020

issue

8

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8 February 2020

page(s)

508-523

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Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

8 February 2020

cites work

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Constructing and decoding unconventional ubiquitin chains.

31 March 2020

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31 March 2020

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Structural mechanisms underlying posttranslational modification by ubiquitin-like proteins

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The diversity of ubiquitin recognition: hot spots and varied specificity

31 March 2020

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Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

31 March 2020

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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

31 March 2020

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Breaking the chains: structure and function of the deubiquitinases

31 March 2020

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Nonproteolytic functions of ubiquitin in cell signaling

31 March 2020

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Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

31 March 2020

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Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

31 March 2020

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K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody

31 March 2020

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Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH

31 March 2020

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The Structure and Conformation of Lys63-Linked Tetraubiquitin

31 March 2020

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

31 March 2020

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Structural properties of polyubiquitin chains in solution

31 March 2020

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Structure of a compact conformation of linear diubiquitin

31 March 2020

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Distinct functional surface regions on ubiquitin

31 March 2020

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A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein

31 March 2020

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Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant

31 March 2020

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Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

31 March 2020

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A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

31 March 2020

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

31 March 2020

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

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Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease

31 March 2020

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A Perturbed Ubiquitin Landscape Distinguishes Between Ubiquitin in Trafficking and in Proteolysis

31 March 2020

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A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles

31 March 2020

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Systematic and quantitative assessment of the ubiquitin-modified proteome

31 March 2020

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Global changes to the ubiquitin system in Huntington's disease.

31 March 2020

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Building ubiquitin chains: E2 enzymes at work

31 March 2020

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E2s: structurally economical and functionally replete

31 March 2020

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UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

31 March 2020

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Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI

31 March 2020

1 reference

FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL

31 March 2020

1 reference

DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.

31 March 2020

1 reference

Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP

31 March 2020

1 reference

Regulation of ubiquitin chain initiation to control the timing of substrate degradation.

31 March 2020

1 reference

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex

31 March 2020

1 reference

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

31 March 2020

1 reference

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology

31 March 2020

1 reference

Lysine-63-linked ubiquitination is required for endolysosomal degradation of class I molecules

31 March 2020

1 reference

Sequential E2s drive polyubiquitin chain assembly on APC targets

31 March 2020

1 reference

Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13

31 March 2020

1 reference

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

31 March 2020

1 reference

Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

31 March 2020

1 reference

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

31 March 2020

1 reference

Physiological functions of the HECT family of ubiquitin ligases

31 March 2020

1 reference

Polyubiquitination by HECT E3s and the determinants of chain type specificity

31 March 2020

1 reference

A HECT domain E3 enzyme assembles novel polyubiquitin chains

31 March 2020

1 reference

Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth.

31 March 2020

1 reference

K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling

31 March 2020

1 reference

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

31 March 2020

1 reference

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

31 March 2020

1 reference

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

31 March 2020

1 reference

Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site

31 March 2020

1 reference

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

31 March 2020

1 reference

Structure and function of a HECT domain ubiquitin‐binding site

31 March 2020

1 reference

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

31 March 2020

1 reference

The ring between ring fingers (RBR) protein family

31 March 2020

1 reference

31 March 2020

Mechanisms of mitophagy

1 reference

LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses.

31 March 2020

1 reference

A ubiquitin ligase complex assembles linear polyubiquitin chains

31 March 2020

1 reference

RING domain E3 ubiquitin ligases

31 March 2020

1 reference

31 March 2020

TRIM proteins and cancer

1 reference

Cellular functions of the DUBs

31 March 2020

1 reference

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

31 March 2020

1 reference

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

31 March 2020

1 reference

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

31 March 2020

1 reference

Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations

31 March 2020

1 reference

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

31 March 2020

1 reference

Structural basis and specificity of human otubain 1-mediated deubiquitination

31 March 2020

1 reference

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

31 March 2020

1 reference

The mechanism of OTUB1-mediated inhibition of ubiquitination

31 March 2020

1 reference

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

31 March 2020

1 reference

Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains.

31 March 2020

1 reference

Linear polyubiquitination: a new regulator of NF-kappaB activation.

31 March 2020

1 reference

The multiple layers of ubiquitin-dependent cell cycle control.

31 March 2020

1 reference

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

31 March 2020

1 reference

Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

31 March 2020

1 reference

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

31 March 2020

1 reference

Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase

31 March 2020

1 reference

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

31 March 2020

1 reference

BRCA1 ubiquitinates RPB8 in response to DNA damage

31 March 2020

1 reference

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

31 March 2020

1 reference

The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function

31 March 2020

1 reference

K11-linked ubiquitin chains as novel regulators of cell division

31 March 2020

1 reference

Identification of a physiological E2 module for the human anaphase-promoting complex

31 March 2020

1 reference

Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression.

31 March 2020

1 reference

Contribution of Lysine 11-linked Ubiquitination to MIR2-mediated Major Histocompatibility Complex Class I Internalization

31 March 2020

1 reference

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

31 March 2020

1 reference

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

31 March 2020

1 reference

The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability

31 March 2020

1 reference

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

31 March 2020

1 reference

The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin

31 March 2020

1 reference

Putative tumor suppressor EDD interacts with and up-regulates APC

31 March 2020

1 reference

Working on a chain: E3s ganging up for ubiquitylation

31 March 2020

1 reference

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases

31 March 2020

1 reference

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

31 March 2020

1 reference

The TNF and TNF receptor superfamilies: integrating mammalian biology

31 March 2020

1 reference

Regulation of death receptor signaling by the ubiquitin system

31 March 2020

1 reference

The role of ubiquitin in NF-kappaB regulatory pathways.

31 March 2020

1 reference

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

31 March 2020

1 reference

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

31 March 2020

1 reference

TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation

31 March 2020

1 reference

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

31 March 2020

1 reference

Linear ubiquitination prevents inflammation and regulates immune signalling

31 March 2020

1 reference

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

31 March 2020

1 reference

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

1 reference

Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.

31 March 2020

1 reference

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

31 March 2020

1 reference

Signal processing by its coil zipper domain activates IKK gamma

31 March 2020

1 reference

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

31 March 2020

1 reference

Ubiquitin interactions of NZF zinc fingers

31 March 2020

1 reference

Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain

31 March 2020

1 reference

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3

31 March 2020

1 reference

Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

31 March 2020

1 reference

NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.

31 March 2020

1 reference

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

31 March 2020

1 reference

Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin

31 March 2020

1 reference

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

31 March 2020

1 reference

The zinc finger of NEMO is a functional ubiquitin-binding domain

31 March 2020

1 reference

NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

31 March 2020

1 reference

NEMO oligomerization and its ubiquitin-binding properties

31 March 2020

1 reference

Structural Basis for Recognition of Diubiquitins by NEMO

31 March 2020

1 reference

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

31 March 2020

1 reference

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

31 March 2020

1 reference

Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense

31 March 2020

1 reference

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response

31 March 2020

1 reference

Differential modification of Ras proteins by ubiquitination

31 March 2020

1 reference

Detection of sequential polyubiquitylation on a millisecond timescale

31 March 2020

1 reference

Recognition of the polyubiquitin proteolytic signal

31 March 2020

1 reference

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

31 March 2020

1 reference

Together, Rpn10 and Dsk2 can serve as a polyubiquitin chain-length sensor

31 March 2020

1 reference

Protein-linked Ubiquitin Chain Structure Restricts Activity of Deubiquitinating Enzymes

31 March 2020

1 reference

Recognition and processing of ubiquitin-protein conjugates by the proteasome

31 March 2020

1 reference

Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation

31 March 2020

1 reference

Generation of Site‐Specific and Enzymatically Stable Conjugates of Recombinant Proteins with Ubiquitin‐Like Modifiers by the CuI‐Catalyzed Azide–Alkyne Cycloaddition

31 March 2020

1 reference

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

31 March 2020

1 reference

A pyrrolysine analogue for site-specific protein ubiquitination

31 March 2020

1 reference

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

31 March 2020

1 reference

Auxiliary-mediated site-specific peptide ubiquitylation.

31 March 2020

1 reference

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

31 March 2020

1 reference

Total Chemical Synthesis of Di‐ubiquitin Chains

31 March 2020

1 reference

Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin

31 March 2020

1 reference

Highly efficient and chemoselective peptide ubiquitylation

31 March 2020

1 reference

Traceless and site-specific ubiquitination of recombinant proteins

31 March 2020

1 reference

Dissecting the ubiquitin pathway by mass spectrometry

31 March 2020

1 reference

Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry

31 March 2020

1 reference

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

31 March 2020

1 reference

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

31 March 2020

1 reference

Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

31 March 2020

1 reference

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

31 March 2020

1 reference

BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.

31 March 2020

1 reference

Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

31 March 2020

1 reference

Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria.

31 March 2020

1 reference

Structure of ubiquitin refined at 1.8 A resolution

31 March 2020

1 reference

Direct activation of protein kinases by unanchored polyubiquitin chains

31 March 2020

1 reference

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

31 March 2020

1 reference

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

31 March 2020

1 reference

12 December 2020

DUBs and disease: activity assays for inhibitor development.

1 reference

12 December 2020

Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2)

1 reference

12 December 2020

Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries

1 reference

12 December 2020

Emerging roles for Lys11-linked polyubiquitin in cellular regulation.

1 reference

12 December 2020

Trends in Biochemical Sciences

11

36

355

A Bremm

2011

1 reference

7 January 2025

Identifiers

DOI

10.1038/NRM3394

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820888%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 February 2020

1037993117

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22820888%20AND%20SRC:MED&resulttype=core&format=json