Isotope labeling experiments in metabolomics and fluxomics (Q37996964)

26 August 2017

Isotope labeling experiments in metabolomics and fluxomics (English)

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26 August 2017

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Sebastian Klein

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PubMed ID

22447740

26 August 2017

Elmar Heinzle

series ordinal

2

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26 August 2017

23 March 2012

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Wiley interdisciplinary reviews. Systems biology and medicine

26 August 2017

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26 August 2017

4

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26 August 2017

261-272

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26 August 2017

3

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Metabolome analysis: the potential of in vivo labeling with stable isotopes for metabolite profiling

26 August 2017

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Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

21 January 2018

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Fluxomics: mass spectrometry versus quantitative imaging

21 January 2018

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The next wave in metabolome analysis

21 January 2018

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Simultaneous extraction of several metabolites of energy metabolism and related substances in mammalian cells: optimization using experimental design.

21 January 2018

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Effective quenching processes for physiologically valid metabolite profiling of suspension cultured Mammalian cells

21 January 2018

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TARDIS-based microbial metabolomics: time and relative differences in systems

21 January 2018

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Tracer-based metabolomics: concepts and practices

21 January 2018

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High-throughput phenomics: experimental methods for mapping fluxomes

21 January 2018

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A method for the simultaneous determination of 3T3-L1 adipocyte metabolites by liquid chromatography/mass spectrometry using [(13)C]-stable isotopes

21 January 2018

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Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2.

21 January 2018

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13C metabolic flux analysis

21 January 2018

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Metabolic networks in motion: 13C-based flux analysis

21 January 2018

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Estimation of metabolic fluxes, expression levels and metabolite dynamics of a secondary metabolic pathway in potato using label pulse-feeding experiments combined with kinetic network modelling and simulation

21 January 2018

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Dynamics and control of the central carbon metabolism in hepatoma cells

21 January 2018

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Quantification of statin effects on hepatic cholesterol synthesis by transient (13)C-flux analysis.

21 January 2018

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KEGG for integration and interpretation of large-scale molecular data sets

21 January 2018

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Latest developments in sample treatment for 18O-isotopic labeling for proteomics mass spectrometry-based approaches: a critical review.

21 January 2018

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Application of stable isotopes and mass isotopomer distribution analysis to the study of intermediary metabolism of nutrients.

21 January 2018

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In folio respiratory fluxomics revealed by 13C isotopic labeling and H/D isotope effects highlight the noncyclic nature of the tricarboxylic acid "cycle" in illuminated leaves

21 January 2018

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A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and C-labeled glucose

21 January 2018

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Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate

21 January 2018

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In vivo 15N-enrichment of metabolites in suspension cultured cells and its application to metabolomics.

21 January 2018

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Analysis of 13C labeling enrichment in microbial culture applying metabolic tracer experiments using gas chromatography-combustion-isotope ratio mass spectrometry

21 January 2018

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13C metabolic flux analysis for larger scale cultivation using gas chromatography-combustion-isotope ratio mass spectrometry

21 January 2018

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Correcting for the effects of natural abundance in stable isotope resolved metabolomics experiments involving ultra-high resolution mass spectrometry

21 January 2018

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Numerical bias estimation for mass spectrometric mass isotopomer analysis.

21 January 2018

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Identification of metabolic fluxes in hepatic cells from transient 13C-labeling experiments: Part I. Experimental observations

21 January 2018

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NMR-based stable isotope resolved metabolomics in systems biochemistry

21 January 2018

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Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism.

21 January 2018

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Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy

21 January 2018

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A critical perspective of the use of (13)C-isotopomer analysis by GCMS and NMR as applied to cardiac metabolism.

21 January 2018

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Eukaryotic metabolism: measuring compartment fluxes

21 January 2018

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13C isotopomer analysis of glutamate by tandem mass spectrometry.

21 January 2018

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Collisional fragmentation of central carbon metabolites in LC-MS/MS increases precision of ¹³C metabolic flux analysis

21 January 2018

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Metabolic flux screening of Saccharomyces cerevisiae single knockout strains on glucose and galactose supports elucidation of gene function

21 January 2018

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Metabolic turnover analysis by a combination of in vivo 13C-labelling from 13CO2 and metabolic profiling with CE-MS/MS reveals rate-limiting steps of the C3 photosynthetic pathway in Nicotiana tabacum leaves

21 January 2018

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The role of liquid chromatography and flow injection analyses coupled to isotope ratio mass spectrometry for studying human in vivo glucose metabolism

21 January 2018

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Metabolic flux analysis of a glycerol-overproducing Saccharomyces cerevisiae strain based on GC-MS, LC-MS and NMR-derived C-labelling data

21 January 2018

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Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer

21 January 2018

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High-throughput metabolic flux analysis based on gas chromatography-mass spectrometry derived 13C constraints.

21 January 2018

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Accumulation of homolanthionine and activation of a novel pathway for isoleucine biosynthesis in Corynebacterium glutamicum McbR deletion strains

21 January 2018

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GC-TOFMS analysis of metabolites in adherent MDCK cells and a novel strategy for identifying intracellular metabolic markers for use as cell amount indicators in data normalization

21 January 2018

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Evaluation of sampling and quenching procedures for the analysis of intracellular metabolites in CHO suspension cells

21 January 2018

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Evaluation of cell damage caused by cold sampling and quenching for metabolome analysis.

21 January 2018

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Towards quantitative metabolomics of mammalian cells: development of a metabolite extraction protocol

21 January 2018

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Development and application of a differential method for reliable metabolome analysis in Escherichia coli.

21 January 2018

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Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria

21 January 2018

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Metabolomics to unveil and understand phenotypic diversity between pathogen populations

21 January 2018

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Bioinformatics tools for cancer metabolomics

21 January 2018

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Database resources in metabolomics: an overview

21 January 2018

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KaPPA-View4: a metabolic pathway database for representation and analysis of correlation networks of gene co-expression and metabolite co-accumulation and omics data

21 January 2018

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Metabolite-balancing techniques vs. 13C tracer experiments to determine metabolic fluxes in hybridoma cells.

21 January 2018

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Metabolic flux analysis in eukaryotes

21 January 2018

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13C metabolic flux analysis in complex systems.

21 January 2018

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Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions

21 January 2018

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Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices

21 January 2018

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Fluxomers: a new approach for 13C metabolic flux analysis

21 January 2018

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Measuring the metabolome: current analytical technologies

21 January 2018

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Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives

21 January 2018

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Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards

21 January 2018

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The benefits of being transient: isotope-based metabolic flux analysis at the short time scale.

21 January 2018

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Doxorubicin increases oxidative metabolism in HL-1 cardiomyocytes as shown by 13C metabolic flux analysis.

21 January 2018

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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

21 January 2018

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Metabolic flux analysis gives an insight on verapamil induced changes in central metabolism of HL-1 cells.

21 January 2018

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Metabolic flux analysis and pharmaceutical production

21 January 2018

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Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.

21 January 2018

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Metabolite channeling and compartmentation in the human cell line AGE1.HN determined by 13C labeling experiments and 13C metabolic flux analysis

21 January 2018

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Metabolic flux rearrangement in the amino acid metabolism reduces ammonia stress in the α1-antitrypsin producing human AGE1.HN cell line

21 January 2018

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Quercetin treatment changes fluxes in the primary metabolism and increases culture longevity and recombinant α₁-antitrypsin production in human AGE1.HN cells

21 January 2018

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Comparison of quantitative metabolite imaging tools and carbon-13 techniques for fluxomics.

21 January 2018

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Fluorescent protein FRET pairs for ratiometric imaging of dual biosensors.

21 January 2018

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Ultrahighly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/WSBM.1167

1 reference

26 August 2017

1 reference

PubMed ID

22447740