Integrin subunit alpha M (Q3799301)

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mammalian protein found in Homo sapiens
  • CD11 antigen-like family member B
  • Neutrophil adherence receptor
  • leukocyte adhesion receptor MO1
  • neutrophil adherence receptor alpha-M subunit
  • ITGAM
  • cell surface glycoprotein MAC-1 subunit alpha
  • CR-3 alpha chain
  • antigen CD11b (p170)
  • integrin alpha-M
  • complement component 3 receptor 3 subunit
  • macrophage antigen alpha polypeptide
  • integrin, alpha M (complement component 3 receptor 3 subunit)
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Language Label Description Also known as
English
Integrin subunit alpha M
mammalian protein found in Homo sapiens
  • CD11 antigen-like family member B
  • Neutrophil adherence receptor
  • leukocyte adhesion receptor MO1
  • neutrophil adherence receptor alpha-M subunit
  • ITGAM
  • cell surface glycoprotein MAC-1 subunit alpha
  • CR-3 alpha chain
  • antigen CD11b (p170)
  • integrin alpha-M
  • complement component 3 receptor 3 subunit
  • macrophage antigen alpha polypeptide
  • integrin, alpha M (complement component 3 receptor 3 subunit)

Statements

molecular function
metal ion binding
determination method
IEA
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
glycoprotein binding
determination method
IPI
1 reference
retrieved
23 May 2017
stated in
Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IPI
protein binding
determination method
IPI
2 references
retrieved
23 May 2017
stated in
JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IPI
retrieved
23 May 2017
stated in
Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IPI
protein heterodimerization activity
determination method
IEA
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Ensembl
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
heat shock protein binding
determination method
IPI
1 reference
retrieved
23 May 2017
stated in
Identification of heat shock protein 60 as the ligand on Histoplasma capsulatum that mediates binding to CD18 receptors on human macrophages
UniProt-GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IPI
cell component
extracellular exosome
determination method
IDA
2 references
retrieved
23 May 2017
stated in
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IDA
retrieved
23 May 2017
stated in
Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IDA
plasma membrane
determination method
TAS
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
cell surface
determination method
IDA
2 references
retrieved
23 May 2017
stated in
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IDA
retrieved
23 May 2017
stated in
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IDA
membrane
determination method
IEA
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
integral component of membrane
determination method
IEA
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
integrin complex
determination method
IEA
TAS
2 references
retrieved
23 May 2017
stated in
cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
retrieved
23 May 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
extracellular space
determination method
IDA
1 reference
retrieved
23 May 2017
stated in
Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IDA
specific granule membrane
determination method
TAS
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
tertiary granule membrane
determination method
TAS
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
biological process
ectodermal cell differentiation
determination method
IEP
1 reference
retrieved
23 May 2017
stated in
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEP
toll-like receptor 4 signaling pathway
determination method
TAS
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
integrin-mediated signaling pathway
determination method
IEA
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
leukocyte migration
determination method
TAS
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
extracellular matrix organization
determination method
TAS
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
cell adhesion
determination method
IEA
TAS
3 references
retrieved
23 May 2017
stated in
cDNA sequence for the alpha M subunit of the human neutrophil adherence receptor indicates homology to integrin alpha subunits
UniProt-GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS
retrieved
23 May 2017
stated in
UniProt-GOA
curator
UniProt
UniProt ID
P11215
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
retrieved
23 May 2017
stated in
UniProt-GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
IEA
neutrophil degranulation
determination method
TAS
1 reference
retrieved
23 May 2017
stated in
UniProt-GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P11215
determination method
TAS

Identifiers

PDB ID
1BHO
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1BHQ
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1IDN
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1IDO
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1JLM
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1M1U
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1MF7
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1N9Z
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
1NA5
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
2LKE
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
2LKJ
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
3Q3G
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
3QA3
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
4M76
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
4XW2
1 reference
stated in
UniProt
UniProt ID
P11215
retrieved
4 August 2016
language of work or name
English
 

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