LIF in the regulation of T-cell fate and as a potential therapeutic (Q37849132)

24 August 2017

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title

LIF in the regulation of T-cell fate and as a potential therapeutic (English)

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24 August 2017

S M Metcalfe

1

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24 August 2017

3 March 2011

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24 August 2017

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24 August 2017

12

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24 August 2017

157-168

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24 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/gene.2011.9

24 August 2017

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Leukemia inhibitory factor is linked to regulatory transplantation tolerance.

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The unsolved enigmas of leukemia inhibitory factor

21 January 2018

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Regulatory network analyses reveal genome-wide potentiation of LIF signaling by glucocorticoids and define an innate cell defense response

21 January 2018

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The neuropoietic cytokine family in development, plasticity, disease and injury

21 January 2018

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A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells

21 January 2018

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21 January 2018

Capturing pluripotency

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Nanog safeguards pluripotency and mediates germline development

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Nanog is the gateway to the pluripotent ground state.

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Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression

21 January 2018

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Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal.

21 January 2018

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Functional immobilization of signaling proteins enables control of stem cell fate

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2.

21 January 2018

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A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FGENE.2011.9

Intracellular and extracellular leukemia inhibitory factor proteins have different cellular activities that are mediated by distinct protein motifs

21 January 2018

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https://api.crossref.org/works/10.1038%2FGENE.2011.9

Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FGENE.2011.9

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

21 January 2018

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Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGENE.2011.9

The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor

21 January 2018

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Solution Structure of the C-terminal Domain of the Ciliary Neurotrophic Factor (CNTF) Receptor and Ligand Free Associations among Components of the CNTF Receptor Complex

21 January 2018

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Mutations in the immunoglobulin-like domain of gp190, the leukemia inhibitory factor (LIF) receptor, increase or decrease its affinity for LIF.

21 January 2018

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Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.

21 January 2018

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Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6.

21 January 2018

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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

21 January 2018

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Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor.

21 January 2018

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The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.

21 January 2018

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FOXP3: of mice and men.

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Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells--how diverse signals regulate suppression

21 January 2018

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

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Foxp3 in control of the regulatory T cell lineage

21 January 2018

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Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

21 January 2018

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Regulatory transplantation tolerance and "stemness": evidence that Foxp3 may play a regulatory role in SOCS-3 gene transcription

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Human naturally occurring and adaptive regulatory T cells secrete high levels of leukaemia inhibitory factor upon activation

21 January 2018

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p53 regulates maternal reproduction through LIF

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038%2FGENE.2011.9

The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FGENE.2011.9

Studies using leukemia inhibitory factor (LIF) knockout mice and a LIF adenoviral vector demonstrate a key anti-inflammatory role for this cytokine in cutaneous inflammation

21 January 2018

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https://api.crossref.org/works/10.1038%2FGENE.2011.9

High weight differences between donor and recipient affect early kidney graft function--a role for enhanced IL-6 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

IL-6 and TNF-alpha synergistically inhibit allograft acceptance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Immune markers for Huntington's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

CNS-targeted LIF expression improves therapeutic efficacy and limits autoimmune-mediated demyelination in a model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

The therapeutic use of gene therapy in inflammatory demyelinating diseases of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

All-trans retinoic acid inhibits type 1 diabetes by T regulatory (Treg)-dependent suppression of interferon-gamma-producing T-cells without affecting Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Retinoic acid: a key player in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Th17 and regulatory T cells in mediating and restraining inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Retinoic acid enhances leukemia inhibitory factor expression in OLN-93 oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Endogenous leukemia inhibitory factor production limits autoimmune demyelination and oligodendrocyte loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

Transplantation tolerance: gene expression profiles comparing allotolerance vs. allorejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Regulation of the human leukemia inhibitory factor gene by ETS transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Production of leukocyte migration inhibitory factor (LIF) in human lymphocyte subsets exposed to polyclonal activators

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Administration of thymocytes derived from non-pregnant mice induces an endometrial receptive stage and leukaemia inhibitory factor expression in the uterus

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Leukemia inhibitory factor gene improves skin allograft survival in the mouse model

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

HILDA/LIF, G.CSF, IL-1 beta, IL-6, and TNF alpha production during acute rejection of human kidney allografts

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

High interleukin-6 plasma levels in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity.

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Therapeutic potential of LIF in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Retinoic acid maintains self-renewal of murine embryonic stem cells via a feedback mechanism

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression

1 reference

https://api.crossref.org/works/10.1038%2FGENE.2011.9

7 January 2021

Identifiers

DOI

10.1038/GENE.2011.9

1 reference

24 August 2017

1 reference

PubMed ID

21368774