Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. (Q37636887)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8633069%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

title

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity (English)

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16 October 2019

2

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16 October 2019

Peter Howley

7

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16 October 2019

author name string

S N Khleif

1

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16 October 2019

C L Yee

3

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16 October 2019

G A Otterson

4

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16 October 2019

F J Kaye

5

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16 October 2019

J R Nevins

6

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16 October 2019

publication date

1 April 1996

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16 October 2019

language of work or name

English

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number of pages

5

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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16 October 2019

volume

93

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16 October 2019

issue

9

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16 October 2019

page(s)

4350-4354

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The retinoblastoma protein as a transcriptional repressor

16 October 2019

cites work

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Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

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Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

23 August 2017

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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

23 August 2017

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Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

23 August 2017

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Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

23 August 2017

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23 August 2017

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

23 August 2017

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Cloning and characterization of murine p16INK4a and p15INK4b genes

23 August 2017

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Growth suppression by p16ink4 requires functional retinoblastoma protein

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

23 August 2017

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The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

23 August 2017

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

6 September 2017

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DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

14 September 2017

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Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product

28 September 2017

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Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.

28 September 2017

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Cyclin-dependent regulation of G1 in mammalian fibroblasts.

28 September 2017

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Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

25 June 2018

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Mechanism of active transcriptional repression by the retinoblastoma protein

25 June 2018

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25 June 2018

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Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

25 June 2018

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25 June 2018

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Identification of a growth suppression domain within the retinoblastoma gene product

25 June 2018

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Retinoblastoma protein switches the E2F site from positive to negative element

25 June 2018

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Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung

25 June 2018

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12 December 2020

Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RB

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12 December 2020

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

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12 December 2020

P16 gene in uncultured tumours

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12 December 2020

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity

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12 December 2020

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

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12 December 2020

The ins and outs of RB: coupling gene expression to the cell cycle clock

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Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

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Identifiers

DOI

10.1073/PNAS.93.9.4350

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8633069%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8633069%20AND%20SRC:MED&resulttype=core&format=json

16 October 2019

PubMed publication ID

8633069

1 reference