The trypanocidal activity of naphthoquinones: a review (Q37634945)

21 August 2017

4 references

22 June 2019

7 November 2019

12 November 2019

13 November 2019

The trypanocidal activity of naphthoquinones: a review (English)

1 reference

21 August 2017

1 reference

7 November 2019

1 reference

12 November 2019

1 reference

13 November 2019

Antônio Ventura Pinto

series ordinal

1

1 reference

PubMed ID

19924086

21 August 2017

Solange Lisboa de Castro

series ordinal

2

1 reference

PubMed ID

19924086

21 August 2017

language of work or name

English

0 references

publication date

10 November 2009

5 references

21 August 2017

22 June 2019

7 November 2019

12 November 2019

13 November 2019

5 references

21 August 2017

22 June 2019

7 November 2019

12 November 2019

13 November 2019

14

1 reference

21 August 2017

4570-4590

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21 August 2017

11

1 reference

Creative Commons Attribution

21 August 2017

4 references

22 June 2019

7 November 2019

12 November 2019

13 November 2019

0 references

Quinone chemistry and toxicity

1 reference

12 December 2020

NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics

1 reference

12 December 2020

Metabolism and reactions of quinoid anticancer agents

1 reference

12 December 2020

Pharmacopeia of Qollahuaya Andeans

1 reference

12 December 2020

Plant metabolites active against Trypanosoma cruzi

1 reference

12 December 2020

Naphthoimidazoles promote different death phenotypes in Trypanosoma cruzi.

1 reference

12 December 2020

Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.

1 reference

12 December 2020

Synthesis of dihydronaphthofurandiones and dihydrofuroquinolinediones with trypanocidal activity and analysis of their stereoelectronic properties

1 reference

12 December 2020

Reaction of beta-lapachone and related naphthoquinones with 2-mercaptoethanol: a biomimetic model of topoisomerase II poisoning by quinones

1 reference

12 December 2020

An update on Chagas disease (human American trypanosomiasis).

1 reference

12 December 2020

Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi

1 reference

12 December 2020

Atovaquone - a novel broad-spectrum anti-infective drug.

1 reference

12 December 2020

Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata

1 reference

12 December 2020

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone

1 reference

12 December 2020

Medicine and magic among the Maka Indians of the Paraguayan Chaco

1 reference

12 December 2020

Effect of β-lapachone on superoxide anion and hydrogen peroxide production in Trypanosoma cruzi

1 reference

12 December 2020

Laboratory-acquired parasitic infections from accidental exposures

1 reference

12 December 2020

Trypanocidal activity of synthetic heterocyclic derivatives of active quinones from Tabebuia sp

1 reference

12 December 2020

Possible oral transmission of acute Chagas' disease in Brazil

1 reference

12 December 2020

Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells

1 reference

12 December 2020

Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

1 reference

12 December 2020

Ketoconazole Protects against Infection with Trypanosoma Cruzi in a Murine Model *

1 reference

12 December 2020

beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin

1 reference

12 December 2020

The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers

1 reference

12 December 2020

Trypanosoma cruzi targets for new chemotherapeutic approaches

1 reference

12 December 2020

Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds

1 reference

12 December 2020

NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity

1 reference

12 December 2020

The efficacy of herbal medicine--an overview

1 reference

12 December 2020

Chemotherapeutically active nitro compounds. 4.5-Nitroimidazoles (Part II)

1 reference

12 December 2020

Plants and human health in the twenty-first century.

1 reference

12 December 2020

Isoxazolylnaphthoquinone effects on the growth of Trypanosoma cruzi.

1 reference

12 December 2020

Electrochemical study of oxygen interaction with lapachol and its radical anions.

1 reference

12 December 2020

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi.

1 reference

12 December 2020

Redox and addition chemistry of quinoid compounds and its biological implications

1 reference

12 December 2020

Biological activity of diospyrin towards Ehrlich ascites carcinoma in Swiss A mice

1 reference

12 December 2020

Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone

1 reference

12 December 2020

[Congenital Chagas disease: from the laboratory to public health]

1 reference

12 December 2020

Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone

1 reference

12 December 2020

"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

1 reference

12 December 2020

Effects of beta-lapachone, a peroxide-generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi

1 reference

12 December 2020

Activity of some naphthoquinones on blood stream forms of Trypanosoma cruzi

1 reference

12 December 2020

Autoxidation of naphthohydroquinones: effects of pH, naphthoquinones and superoxide dismutase

1 reference

12 December 2020

Different cell death pathways induced by drugs in Trypanosoma cruzi: an ultrastructural study

1 reference

12 December 2020

1-(substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi in mice

1 reference

12 December 2020

Characterization of Trypanosoma cruzi isolated from humans, vectors, and animal reservoirs following an outbreak of acute human Chagas disease in Santa Catarina State, Brazil.

1 reference

12 December 2020

Natural health products and drug disposition

1 reference

12 December 2020

Antitumoral and toxicological properties of extracts of bark and various wood components of Pau d'arco (Tabebuia avellanedae)

1 reference

12 December 2020

Biological and chemical studies of Pera benensis, a Bolivian plant used in folk medicine as a treatment of cutaneous leishmaniasis

1 reference

12 December 2020

Separation methods of quinonoid constituents of plants used in Oriental traditional medicines

1 reference

12 December 2020

Evaluation of the toxicity of 3-allyl-beta-lapachone against Trypanosoma cruzi bloodstream forms

1 reference

12 December 2020

Lipid peroxidation and the generation of free radicals, superoxide anion, and hydrogen peroxide in β-lapachone-treated Trypanosoma cruzi epimastigotes

1 reference

12 December 2020

The influence of natural products upon drug discovery

1 reference

12 December 2020

Risk factors for Chagas' disease reactivation after heart transplantation

1 reference

12 December 2020

Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy

1 reference

12 December 2020

Generation of Superoxide Anions and Hydrogen Peroxide from β-Lapachone in Bacteria

1 reference

12 December 2020

Structure-activity relationships in the haemolytic activity and nephrotoxicity of derivatives of 1,2- and 1,4-naphthoquinone

1 reference

12 December 2020

Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones

1 reference

12 December 2020

Redox cycling of beta-lapachone and structural analogues in microsomal and cytosol liver preparations

1 reference

12 December 2020

Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and beta-lapachone combination treatment

1 reference

12 December 2020

Mitochondrial disruption and DNA fragmentation in Trypanosoma cruzi induced by naphthoimidazoles synthesized from beta-lapachone.

1 reference

12 December 2020

Diversity of DNA topoisomerases I and inhibitors.

1 reference

12 December 2020

Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones.

1 reference

12 December 2020

Adducts of nitroimidazole derivatives with rhodium(II) carboxylates: syntheses, characterization, and evaluation of antichagasic activities

1 reference

12 December 2020

The activity of hydroxynaphthoquinones against Leishmania donovani

1 reference

12 December 2020

Global framework on essential health R&D.

1 reference

12 December 2020

Synthesis and biological evaluation of pyrazolylnaphthoquinones as new potential antiprotozoal and cytotoxic agents

1 reference

12 December 2020

Potent inhibition of tumor survival in vivo by beta-lapachone plus taxol: combining drugs imposes different artificial checkpoints

1 reference

12 December 2020

Screening of natural and synthetic drugs against Trypanosoma cruzi. 1. Establishing a structure/activity relationship

1 reference

12 December 2020

In vitroandin vivoevaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives againstTrypanosoma cruzi

1 reference

12 December 2020

Epidemiology of Chagas disease in non-endemic countries: the role of international migration.

1 reference

12 December 2020

Antiparasitic properties of medicinal plants and other naturally occurring products

1 reference

12 December 2020

beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.

1 reference

12 December 2020

The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis.

1 reference

12 December 2020

Induction of apoptosis by beta-lapachone in human prostate cancer cells.

1 reference

12 December 2020

Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response

1 reference

12 December 2020

Cancer therapy with beta-lapachone

1 reference

12 December 2020

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

1 reference

12 December 2020

Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone

1 reference

12 December 2020

Inhibition of radiation-induced neoplastic transformation by beta-lapachone

1 reference

12 December 2020

Natural products as sources of new drugs over the last 25 years

1 reference

12 December 2020

Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.

1 reference

12 December 2020

Cytotoxicity of beta-lapachone, an naphthoquinone with possible therapeutic use

1 reference

12 December 2020

Tropical rain forests: potential source of new drugs?

1 reference

12 December 2020

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

1 reference

12 December 2020

Drug development for neglected diseases: a deficient market and a public-health policy failure

1 reference

12 December 2020

Molecular mechanisms of quinone cytotoxicity

1 reference

12 December 2020

Synthesis, antiprotozoal and cytotoxic activities of new N-(3,4-dimethyl-5-isoxazolyl)-1,2-naphthoquinone-4-amino derivatives

1 reference

12 December 2020

8-Methoxy-naphtho[2,3-b]thiophen-4,9-quinone, a non-competitive inhibitor of trypanothione reductase

1 reference

12 December 2020

Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles

1 reference

12 December 2020

Oral drug therapy for multiple neglected tropical diseases: a systematic review

1 reference

12 December 2020

Natural products to drugs: natural product-derived compounds in clinical trials

1 reference

12 December 2020

Redox cycling of o-naphthoquinones in trypanosomatids. Superoxide and hydrogen peroxide production

1 reference

12 December 2020

Chagas' disease and AIDS

1 reference

12 December 2020

New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors

1 reference

12 December 2020

Role of quinones in toxicology.

1 reference

12 December 2020

The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction

1 reference

12 December 2020

A critical review on Chagas disease chemotherapy

1 reference

12 December 2020

2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation

1 reference

12 December 2020

[Globalization, inequity and Chagas disease]

1 reference

12 December 2020

Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi.

1 reference

12 December 2020

An update on the management of Chagas cardiomyopathy

1 reference

12 December 2020

Control of neglected tropical diseases

1 reference

12 December 2020

Inhibition of microsomal lipid peroxidation and cytochrome P-450-catalyzed reactions by beta-lapachone and related naphthoquinones

1 reference

12 December 2020

Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones

1 reference

12 December 2020

Privileged structures as leads in medicinal chemistry.

1 reference

12 December 2020

A trypanocidal phenazine derived from beta-lapachone.

1 reference

12 December 2020

The combinatorial synthesis of bicyclic privileged structures or privileged substructures.

1 reference

12 December 2020

10.3390/MOLECULES14114570

Identifiers

DOI

1 reference

21 August 2017

0 references

1 reference

PubMed ID

19924086