Design and chemical synthesis of integrin ligands (Q36909857)

17 August 2017

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title

Design and chemical synthesis of integrin ligands (English)

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17 August 2017

Dominik Heckmann

1

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17 August 2017

Horst Kessler

series ordinal

2

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17 August 2017

language of work or name

English

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publication date

1 January 2007

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17 August 2017

published in

Methods in Enzymology

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17 August 2017

volume

426

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17 August 2017

page(s)

463-503

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The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain

17 August 2017

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Photoswitched cell adhesion on surfaces with RGD peptides

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7 January 2021

Benzylprotected aromatic phosphonic acids for anchoring peptides on titanium

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7 January 2021

Titanium implant materials with improved biocompatibility through coating with phosphonate-anchored cyclic RGD peptides.

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7 January 2021

Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1.

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7 January 2021

Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins

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7 January 2021

Biological evaluation of thrombus imaging agents utilizing water soluble phosphines and tricine as coligands when used to label a hydrazinonicotinamide-modified cyclic glycoprotein IIb/IIIa receptor antagonist with 99mTc

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7 January 2021

Biological evaluation of 99mTc-labeled cyclic glycoprotein IIb/IIIa receptor antagonists in the canine arteriovenous shunt and deep vein thrombosis models: effects of chelators on biological properties of [99mTc]chelator-peptide conjugates

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7 January 2021

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis

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7 January 2021

Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

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7 January 2021

A Stereoselective Synthesis of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester

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7 January 2021

1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive

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7 January 2021

9-Fluorenylmethoxycarbonyl amino-protecting group

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7 January 2021

Solid-phase peptide synthesis of somatostatin using mild base cleavage of N alpha-9-fluorenylmethyloxycarbonylamino acids

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7 January 2021

Re-epithelialization of normal human excisional wounds is associated with a switch from alpha v beta 5 to alpha v beta 6 integrins

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7 January 2021

Integrins and cardiovascular disease

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7 January 2021

Non-peptide alpha(v)beta(3) antagonists. Part 4: potent and orally bioavailable chain-shortened RGD mimetics

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7 January 2021

Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Improving implant materials by coating with nonpeptidic, highly specific integrin ligands.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

(Arg-Gly-Asp)n-albumin conjugates as a model substratum for integrin-mediated cell adhesion

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7 January 2021

N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

New and versatile ternary ligand system for technetium radiopharmaceuticals: water soluble phosphines and tricine as coligands in labeling a hydrazinonicotinamide-modified cyclic glycoprotein IIb/IIIa receptor antagonist with 99mTc

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

A convenient synthesis of novel bifunctional prochelators for coupling to bioactive peptides for radiometal labelling

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Binding model for nonpeptide antagonists of alpha(v)beta(3) integrin

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Synthesis of target-specific radiolabeled peptides for diagnostic imaging

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Definition of Two Angiogenic Pathways by Distinct alpha(v) Integrins

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Nonpeptidic αv β3 Integrin Antagonist Libraries: On-Bead Screening and Mass Spectrometric Identification without Tagging

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Therapeutic potential of RGD peptides in acute renal injury

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

A three-state mechanism of integrin activation and signal transduction for integrin alpha(v)beta(3).

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

A computational model of transmembrane integrin clustering

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

The interaction of proteins with solid surfaces

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Conformation/activity studies of rationally designed potent anti-adhesive RGD peptides

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization

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7 January 2021

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

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7 January 2021

Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD

1 reference

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7 January 2021

Radiolabeled tracers for imaging of tumor angiogenesis and evaluation of anti-angiogenic therapies

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7 January 2021

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

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7 January 2021

Cell-attachment activities of surface immobilized oligopeptides RGD, RGDS, RGDV, RGDT, and YIGSR toward five cell lines

1 reference

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7 January 2021

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

A reevaluation of integrins as regulators of angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

RGD-peptides for tissue engineering of articular cartilage

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Integrins: roles in cancer development and as treatment targets

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

New coupling reagents in peptide chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Materials characteristics of uncoated/ceramic-coated implant materials

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Carbohydrate Derivatives for Use in Drug Design: Cyclicαv-Selective RGD Peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Conformational energy studies on N-methylated analogs of thyrotropin releasing hormone, enkephalin, and luteinizing hormone-releasing hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Human integrin alphavbeta5: homology modeling and ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Docking studies on alphavbeta3 integrin ligands: pharmacophore refinement and implications for drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Bradykinin analogues containing N alpha-methyl amino acids.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Convenient synthesis of bifunctional tetraaza macrocycles

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Pharmacophore refinement of gpIIb/IIIa antagonists based on comparative studies of antiadhesive cyclic and acyclic RGD peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Coordinated expression of the vitronectin receptor and the urokinase-type plasminogen activator receptor in metastatic melanoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Variants of the cell recognition site of fibronectin that retain attachment-promoting activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Ligand binding to integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Interpretation of protein adsorption: surface-induced conformational changes.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Adhesion receptors in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Role of the alpha v beta 3 integrin in human melanoma cell invasion

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Topochemical investigations of peptide systems.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Design and synthesis of a new class of selective integrin alpha5beta1 antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Solid-phase synthesis of a nonpeptide RGD mimetic library: new selective alphavbeta3 integrin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Structure of integrin alpha5beta1 in complex with fibronectin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Multimeric cyclic RGD peptides as potential tools for tumor targeting: solid-phase peptide synthesis and chemoselective oxime ligation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

The effects of isolated N-methylated residues on the conformational characteristics of polypeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Differential structural requirements for fibrinogen binding to platelets and to endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

A new, long-lasting competitive inhibitor of angiotensin

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Relevance of positron emission tomography (PET) in oncology.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

A comparative study of N.C.A. fluorine-18 labeling of proteins via acylation and photochemical conjugation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Ibritumomab tiuxetan radioimmunotherapy for patients with relapsed or refractory non-Hodgkin lymphoma and mild thrombocytopenia: a phase II multicenter trial.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

The effect of calcium phosphate implant coating on osteoconduction

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

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https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2926020-3

7 January 2021

10.1016/S0076-6879(07)26020-3

Identifiers

DOI

1 reference

17 August 2017

1 reference