Modeling oncogene addiction using RNA interference. (Q36840172)

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12 January 2020

title

Modeling oncogene addiction using RNA interference (English)

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12 January 2020

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4

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12 January 2020

5

Daniel A Haber

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12 January 2020

author name string

S Michael Rothenberg

1

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12 January 2020

Jeffrey A Engelman

2

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12 January 2020

Sheila Le

3

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12 January 2020

Jeffrey Settleman

6

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12 January 2020

publication date

18 August 2008

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Proceedings of the National Academy of Sciences of the United States of America

12 January 2020

language of work or name

English

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number of pages

5

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based on heuristic

inferred from page(s)

published in

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12 January 2020

volume

105

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12 January 2020

issue

34

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12 January 2020

page(s)

12480-12484

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describes a project that uses

12 January 2020

1 reference

Survival of cancer cells is maintained by EGFR independent of its kinase activity

1 reference

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Patterns of somatic mutation in human cancer genomes

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1 reference

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Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib

29 September 2017

1 reference

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Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib

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1 reference

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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1 reference

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Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

29 September 2017

1 reference

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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

29 September 2017

1 reference

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Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

29 September 2017

1 reference

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Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

29 September 2017

1 reference

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ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

29 September 2017

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

Expression profiling reveals off-target gene regulation by RNAi

29 September 2017

1 reference

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

29 September 2017

1 reference

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Reversible tumorigenesis by MYC in hematopoietic lineages

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

Essential role for oncogenic Ras in tumour maintenance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

5 September 2018

1 reference

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Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2517605

Minimizing the risk of reporting false positives in large-scale RNAi screens

5 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0803217105

Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0803217105

21 January 2018

Identifiers

DOI

10.1073/PNAS.0803217105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18711136%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

0 references

1 reference

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12 January 2020

PubMed publication ID

18711136

1 reference