Hypothesis: Huntingtin may function in membrane association and vesicular trafficking (Q36704515)

15 August 2017

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title

Hypothesis: Huntingtin may function in membrane association and vesicular trafficking (English)

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15 August 2017

Ray Truant

1

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PubMed ID

17215878

15 August 2017

Randy Atwal

series ordinal

2

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PubMed ID

17215878

15 August 2017

Anjee Burtnik

series ordinal

3

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15 August 2017

1 December 2006

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Biochemistry and Cell Biology

15 August 2017

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15 August 2017

84

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15 August 2017

912-917

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15 August 2017

6

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HEAT repeats in the Huntington's disease protein

15 August 2017

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Comparison of ARM and HEAT protein repeats

21 January 2018

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Fast transport and retrograde movement of huntingtin and HAP 1 in axons.

21 January 2018

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Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases

21 January 2018

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Structure of importin-beta bound to the IBB domain of importin-alpha

21 January 2018

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Polyglutamine expansion of huntingtin impairs its nuclear export

21 January 2018

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Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation

21 January 2018

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Dynactin polices two-way organelle traffic

21 January 2018

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

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Mechanism of action of the immunosuppressant rapamycin

21 January 2018

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Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

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Huntingtin interacts with a family of WW domain proteins

21 January 2018

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21 January 2018

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Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

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Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

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Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

21 January 2018

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Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

21 January 2018

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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

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The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

21 January 2018

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A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila

21 January 2018

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Huntingtin associates with acidic phospholipids at the plasma membrane

21 January 2018

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Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins.

21 January 2018

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

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Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease

21 January 2018

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E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme

21 January 2018

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Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

21 January 2018

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A huntingtin-associated protein enriched in brain with implications for pathology

21 January 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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COP and clathrin-coated vesicle budding: different pathways, common approaches

21 January 2018

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Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors

21 January 2018

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Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease

21 January 2018

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Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis

21 January 2018

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Cytoskeletal motors and cargo in membrane trafficking: opportunities for high specificity in drug intervention

21 January 2018

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A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.

21 January 2018

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Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

21 January 2018

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Lipid regulation of the synaptic vesicle cycle.

21 January 2018

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Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

21 January 2018

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SUMO modification of Huntingtin and Huntington's disease pathology

21 January 2018

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Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import.

21 January 2018

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Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

21 January 2018

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Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease

21 January 2018

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Structural view of the Ran-Importin beta interaction at 2.3 A resolution

21 January 2018

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HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

21 January 2018

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 January 2018

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Kinetic regulation of vesicle endocytosis at synapses

21 January 2018

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Huntingtin contains a highly conserved nuclear export signal

21 January 2018

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Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

21 January 2018

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

21 January 2018

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Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O06-181

1 reference

15 August 2017

1 reference

PubMed ID

17215878