Role of cholesterol and lipid organization in disease (Q36327808)

13 August 2017

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title

Role of cholesterol and lipid organization in disease (English)

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13 August 2017

Frederick R Maxfield

1

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13 August 2017

Ira Tabas

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

1 December 2005

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13 August 2017

10

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inferred from page(s)

published in

Nature

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13 August 2017

438

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13 August 2017

612-621

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13 August 2017

7068

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https://scigraph.springernature.com/pub.10.1038/nature04399

13 August 2017

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7 January 2021

Model systems, lipid rafts, and cell membranes

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Lipid segregation and IgE receptor signaling: a decade of progress

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Molecular medicine. The cholesterol quartet

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Cholesterol, statins and dementia.

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7 January 2021

Functional rafts in cell membranes

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Lipid rafts: elusive or illusive?

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7 January 2021

How proteins move lipids and lipids move proteins.

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7 January 2021

Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains

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7 January 2021

Membrane targeting of lipid modified signal transduction proteins.

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7 January 2021

Partitioning of lipidated peptide sequences into liquid-ordered lipid domains in model and biological membranes

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.

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7 January 2021

Cholesterol and the Golgi apparatus

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Modulation of the bilayer thickness of exocytic pathway membranes by membrane proteins rather than cholesterol

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Membrane lipid organization is critical for human neutrophil polarization.

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Macrophage cholesterol transport: a critical player in foam cell formation

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Intracellular cholesterol transport

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Intracellular cholesterol trafficking: role of the NPC1 protein

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Lipid and cholesterol trafficking in NPC.

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Acyl-coenzyme A:cholesterol acyltransferase

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Hormone-sensitive lipase--new roles for an old enzyme

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Consequences of cellular cholesterol accumulation: basic concepts and physiological implications

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Cholesterol is superior to 7-ketocholesterol or 7 alpha-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1

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7 January 2021

How cholesterol homeostasis is regulated by plasma membrane cholesterol in excess of phospholipids

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Regulation and mechanisms of macrophage cholesterol efflux

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Function of prokaryotic and eukaryotic ABC proteins in lipid transport

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Cellular cholesterol efflux

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux

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7 January 2021

Oxysterols: modulators of cholesterol metabolism and other processes

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7 January 2021

Retinoic Acid Receptor-Mediated Induction of ABCA1 in Macrophages

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7 January 2021

Nuclear receptors and lipid physiology: opening the X-files

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7 January 2021

ATP-binding cassette transporter A1 and cholesterol trafficking

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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7 January 2021

Polyunsaturated fatty acid regulation of genes of lipid metabolism

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7 January 2021

Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

The pathophysiology and mechanisms of NP-C disease.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Endocytic trafficking of glycosphingolipids in sphingolipid storage diseases

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

The response-to-retention hypothesis of early atherogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Inflammation, atherosclerosis, and coronary artery disease

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Evidence for a role of phospholipid oxidation products in atherogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Atherosclerosis. the road ahead

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl prot

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Elevated plasma membrane cholesterol content alters macrophage signaling and function.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Nonoxidative modifications of lipoproteins in atherogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Oxidation, lipoproteins, and atherosclerosis: which is wrong, the antioxidants or the theory?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Remnant lipoproteins and atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Clinical practice. Chronic stable angina

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Evolving concepts in the triad of atherosclerosis, inflammation and thrombosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Vulnerable plaque: the pathology of unstable coronary lesions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Progression of atheroma: a struggle between death and procreation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Apoptosis in the atherosclerotic plaque: quantitative and qualitative aspects

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Role of caspases in death and survival of the plaque macrophage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and a

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Orchestrating the unfolded protein response in health and disease

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Fluorescence probes in metastatic B16 melanoma membranes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Update on statins: 2003.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Neuronal membrane cholesterol loss enhances amyloid peptide generation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Condensed complexes of cholesterol and phospholipids

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https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Structure and origin of ordered lipid domains in biological membranes.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Ternary phase diagram of dipalmitoyl-PC/dilauroyl-PC/cholesterol: nanoscopic domain formation driven by cholesterol

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Ceramide selectively displaces cholesterol from ordered lipid domains (rafts): implications for lipid raft structure and function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Sphingolipid partitioning into ordered domains in cholesterol-free and cholesterol-containing lipid bilayers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04399

7 January 2021

Identifiers

DOI

10.1038/NATURE04399

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Dimensions Publication ID

13 August 2017

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