Targeting mutant p53 shows promise for sunscreens and skin cancer (Q36173619)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060027%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Targeting mutant p53 shows promise for sunscreens and skin cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060027%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

1

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29 December 2019

author name string

Wafik S El-Deiry

series ordinal

1

1 reference

12 August 2017

1 December 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060027%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

29 December 2019

language of work or name

English

0 references

published in

1 reference

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29 December 2019

volume

117

1 reference

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29 December 2019

issue

12

1 reference

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29 December 2019

page(s)

3658-3660

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060027%20AND%20SRC:MED&resulttype=core&format=json

CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice

29 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Management of nonmelanoma skin cancer in 2007.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

1 October 2017

Tanning and skin cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Biological and clinical importance of the p53 tumor suppressor gene.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

p53 mutations in basal cell carcinomas

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Oncology. Recruiting the cell's own guardian for cancer therapy

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2096462

Pharmacological rescue of mutant p53 conformation and function

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18060027

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sunlight and skin cancer: inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18060027

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI34251

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060027%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18060027%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

18060027

1 reference