Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma (Q36091283)

12 August 2017

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma (English)

1 reference

12 August 2017

3

1 reference

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14 June 2020

Kristopher A Sarosiek

4

1 reference

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14 June 2020

Dekuang Zhao

5

1 reference

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14 June 2020

9

Izidore S Lossos

1 reference

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14 June 2020

8

Anthony Letai

1 reference

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14 June 2020

author name string

Shruti Bhatt

1

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14 June 2020

Julie Matthews

2

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14 June 2020

Xiaoyu Jiang

6

1 reference

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14 June 2020

Elif Isik

7

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14 June 2020

publication date

20 July 2015

1 reference

12 August 2017

language of work or name

0 references

1 reference

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14 June 2020

volume

126

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14 June 2020

issue

13

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14 June 2020

page(s)

1555-1564

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Interleukin-21 Enhances Rituximab Activity in a Cynomolgus Monkey Model of B Cell Depletion and in Mouse B Cell Lymphoma Models

14 June 2020

cites work

1 reference

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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

2 October 2017

1 reference

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A Phase I Dose-Finding Trial of Recombinant Interleukin-21 and Rituximab in Relapsed and Refractory Low Grade B-cell Lymphoproliferative Disorders

2 October 2017

1 reference

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Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

2 October 2017

1 reference

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Interleukin-21: updated review of Phase I and II clinical trials in metastatic renal cell carcinoma, metastatic melanoma and relapsed/refractory indolent non-Hodgkin's lymphoma

2 October 2017

1 reference

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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

2 October 2017

1 reference

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Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas.

2 October 2017

1 reference

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Interleukin-21 effectively induces apoptosis in mantle cell lymphoma through a STAT1-dependent mechanism

2 October 2017

1 reference

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IL-21: an executor of B cell fate

2 October 2017

1 reference

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Control of mitochondrial apoptosis by the Bcl-2 family

2 October 2017

1 reference

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Distinct thresholds govern Myc's biological output in vivo

2 October 2017

1 reference

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Interleukin 21: combination strategies for cancer therapy

2 October 2017

1 reference

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IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro

2 October 2017

1 reference

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Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

2 October 2017

1 reference

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High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma

2 October 2017

1 reference

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An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma

2 October 2017

1 reference

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Interleukin 21 therapy increases the density of tumor infiltrating CD8+ T cells and inhibits the growth of syngeneic tumors

2 October 2017

1 reference

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The molecular basis of IL-21-mediated proliferation

2 October 2017

1 reference

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c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.

2 October 2017

1 reference

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Interleukin-21 enhances NK cell activation in response to antibody-coated targets

2 October 2017

1 reference

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

2 October 2017

1 reference

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Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells

2 October 2017

1 reference

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Current treatment approaches for mantle-cell lymphoma

2 October 2017

1 reference

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Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

2 October 2017

1 reference

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IL-21 induces the functional maturation of murine NK cells

2 October 2017

1 reference

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Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1

2 October 2017

1 reference

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

2 October 2017

1 reference

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Bax is a transcriptional target and mediator of c-myc-induced apoptosis.

2 October 2017

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

2 October 2017

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2 October 2017

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Mechanisms of apoptosis by c-Myc

2 October 2017

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STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line

2 October 2017

1 reference

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B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.

2 October 2017

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IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells

11 July 2018

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STAT3 is required for the gp130-mediated full activation of the c-myc gene

11 July 2018

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Murine mantle cell lymphoma model cell line

11 July 2018

1 reference

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Clinical and biological efficacy of recombinant human interleukin-21 in patients with stage IV malignant melanoma without prior treatment: a phase IIa trial.

23 September 2018

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Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo

23 September 2018

1 reference

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Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the Eur

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4582332

Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4582332

Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: molecular complete responses are not predictive of progression-free survival

23 September 2018

1 reference

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Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma

23 September 2018

1 reference

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Differential effects of IL-15 and IL-21 in myeloid (CD11b+) and lymphoid (CD11b-) bone marrow cells

23 September 2018

1 reference

12 December 2020

IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity

1 reference

12 December 2020

IL-21 induces the apoptosis of resting and activated primary B cells

1 reference

12 December 2020

In vivo antitumor activity of interleukin 21 mediated by natural killer cells

1 reference

12 December 2020

Mantle cell lymphoma: a clinicopathologic study of 80 cases

1 reference

12 December 2020

Mantle cell lymphoma: clinical features, treatment and prognosis of 94 patients

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12 December 2020

Mantle cell lymphoma: a retrospective study of 121 cases

1 reference

12 December 2020

Phase I study of recombinant interleukin-21 in patients with metastatic melanoma and renal cell carcinoma

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12 December 2020

10.1182/BLOOD-2015-01-624585

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26194763%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference

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14 June 2020

PubMed publication ID

26194763

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26194763%20AND%20SRC:MED&resulttype=core&format=json