Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor (Q35925395)

11 August 2017

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor (English)

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11 August 2017

4

B K Kobilka

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11 August 2017

P Ghanouni

1

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11 August 2017

J J Steenhuis

series ordinal

2

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11 August 2017

D L Farrens

series ordinal

3

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11 August 2017

15 May 2001

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Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

language of work or name

English

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published in

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11 August 2017

98

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11 August 2017

11

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11 August 2017

5997-6002

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Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling.

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Crystal structure of rhodopsin: A G protein-coupled receptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Site-specific fluorescence labeling of the beta2 adrenergic receptor amino terminus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Structure and function of G protein-coupled receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Structural features required for ligand binding to the beta-adrenergic receptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Adrenergic receptors as models for G protein-coupled receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Restricting the mobility of Gs alpha: impact on receptor and effector coupling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

G protein-coupled receptors. II. Mechanism of agonist activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

G protein-coupled receptors. I. Diversity of receptor-ligand interactions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Rhodopsin: A Prototypical G Protein-Coupled Receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=33412

Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The Beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor

11 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.101126198

Differential transcriptional activation in vitro by NF-kappa B/Rel proteins

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.101126198

Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes

21 January 2018

1 reference

12 December 2020

Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state

1 reference

12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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12 December 2020

The steric trigger in rhodopsin activation

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12 December 2020

Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment

1 reference

12 December 2020

Conformational changes in rhodopsin. Movement of helix f detected by site-specific chemical labeling and fluorescence spectroscopy

1 reference

12 December 2020

Mapping of beta-adrenoceptor coupling domains to Gs-protein by site-specific synthetic peptides

1 reference

12 December 2020

Specific activation of Gs by synthetic peptides corresponding to an intracellular loop of the beta-adrenergic receptor

1 reference

12 December 2020

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process

1 reference

12 December 2020

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1 reference

12 December 2020

Luminescence quenching by nitroxide spin labels in aqueous solution: studies on the mechanism of quenching

1 reference

12 December 2020

Photoactivated conformational changes in rhodopsin: a time-resolved spin label study

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.101126198

1 reference

11 August 2017

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11 August 2017

PubMed publication ID

11353823

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