adiponectin (Q357439)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15848

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.94.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

C1q domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

collagen triple helix repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

0 references

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

signaling receptor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

3 references

9 May 2019

9 May 2019

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

cytokine activity

NAS

1 reference

9 May 2019

The role of the novel adipocyte-derived hormone adiponectin in human disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

NAS

sialic acid binding

1 reference

9 May 2019

Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

protein homodimerization activity

IPI

1 reference

9 May 2019

Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

IPI

protein binding

extracellular matrix structural constituent

IPI

2 references

1 reference

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

extracellular matrix structural constituent

extracellular matrix structural constituent

RCA

RCA

1 reference

9 May 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

RCA

cell component

cell surface

1 reference

9 May 2019

Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

collagen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

1 reference

9 May 2019

extracellular space

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidaemia (FCH)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

27 March 2018

27 March 2018

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

protein-containing complex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

9 May 2019

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

collagen-containing extracellular matrix

1 reference

9 May 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of protein phosphorylation

biological process

1 reference

9 May 2019

Adiponectin regulates albuminuria and podocyte function in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of receptor binding

1 reference

9 May 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

low-density lipoprotein particle clearance

1 reference

9 May 2019

Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of blood pressure

1 reference

9 May 2019

Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of macrophage differentiation

1 reference

9 May 2019

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of synaptic transmission

1 reference

9 May 2019

Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

generation of precursor metabolites and energy

TAS

1 reference

9 May 2019

Organization of the gene for gelatin-binding protein (GBP28)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

cellular response to epinephrine stimulus

TAS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

regulation of glucose metabolic process

1 reference

9 May 2019

Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

circadian rhythm

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of interleukin-8 production

1 reference

9 May 2019

Induction of chemokine expression by adiponectin in vitro is isoform dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

glucose metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

3 references

9 May 2019

9 May 2019

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

protein heterotrimerization

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of heterotypic cell-cell adhesion

1 reference

9 May 2019

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to ethanol

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of inflammatory response

The role of the novel adipocyte-derived hormone adiponectin in human disease

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

cellular response to cAMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of protein kinase A signaling

1 reference

9 May 2019

Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of platelet-derived growth factor receptor signaling pathway

positive regulation of protein metabolic process

1 reference

9 May 2019

Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to linoleic acid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

glucose homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

3 references

9 May 2019

9 May 2019

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

adiponectin-activated signaling pathway

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

response to tumor necrosis factor

1 reference

9 May 2019

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of blood pressure

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

response to nutrient levels

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of cholesterol efflux

1 reference

9 May 2019

Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

fatty acid beta-oxidation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

3 references

9 May 2019

9 May 2019

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of tumor necrosis factor production

1 reference

9 May 2019

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

protein localization to plasma membrane

1 reference

9 May 2019

Adiponectin regulates albuminuria and podocyte function in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of hormone secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to sucrose

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of granulocyte differentiation

1 reference

9 May 2019

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to nutrient

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of protein autophosphorylation

1 reference

9 May 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of intracellular protein transport

1 reference

9 May 2019

Adiponectin regulates albuminuria and podocyte function in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

membrane depolarization

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

positive regulation of myeloid cell apoptotic process

1 reference

9 May 2019

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

9 May 2019

Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of cAMP-dependent protein kinase activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

Adiponectin regulates albuminuria and podocyte function in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

Induction of chemokine expression by adiponectin in vitro is isoform dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of DNA biosynthetic process

1 reference

9 May 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of protein kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to hypoxia

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of phagocytosis

1 reference

9 May 2019

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

membrane hyperpolarization

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15848&geneProductId=UniProtKB:Q15848

negative regulation of tumor necrosis factor-mediated signaling pathway

1 reference

9 May 2019

Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of monocyte chemotactic protein-1 production

1 reference

9 May 2019

Induction of chemokine expression by adiponectin in vitro is isoform dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to glucocorticoid

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of macrophage derived foam cell differentiation

1 reference

9 May 2019

Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

regulation of fatty acid biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

1 reference

9 May 2019

regulation of signaling receptor activity

TAS

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of vascular associated smooth muscle cell proliferation

1 reference

9 May 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of vascular associated smooth muscle cell migration

1 reference

9 May 2019

Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

response to bacterium

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

positive regulation of cold-induced thermogenesis

Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

negative regulation of cold-induced thermogenesis

Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

signal transduction

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15848

http://purl.uniprot.org/uniprot/Q15848

exact match

1 reference

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15848

Collagen triple helix repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q15848

Identifiers

MeSH descriptor ID

C499918

subject named as

ADIPOQ protein, human

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

0 references

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID (discontinued)

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

archive URL

https://web.archive.org/web/20220125070108/https://docs.openalex.org/download-snapshot/snapshot-data-format

25 January 2022

1 reference

21 March 2016

language of work or name

English

Store medisinske leksikon ID

adiponektin

0 references

Transporter Classification Database ID

8.A.94.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

subject named as (monolingual text)

adiponektiini (Finnish)

adiponektin (Swedish)

adiponektiidna (Northern Sami)

adiponectin (English)

1 reference