The Bcl-2 family: roles in cell survival and oncogenesis. (Q35591695)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634621%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

title

The Bcl-2 family: roles in cell survival and oncogenesis (English)

1 reference

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Bcl-2 family protein complex

21 December 2019

main subject

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634621%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

David C Huang

2

1 reference

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21 December 2019

Jerry Adams

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634621%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

author name string

David C S Huang

2

1 reference

9 August 2017

Jerry M Adams

3

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9 August 2017

publication date

1 November 2003

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21 December 2019

language of work or name

0 references

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21 December 2019

volume

22

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14634621%20AND%20SRC:MED&resulttype=core&format=json

21 December 2019

issue

53

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21 December 2019

page(s)

8590-8607

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publication type of scholarly work

21 December 2019

review article

1 reference

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The Bcl-2 protein family: arbiters of cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosomes: engines for caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Death Receptors: Signaling and Modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Senescence: a companion in chemotherapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BAD/BCL-[X(L)] heterodimerization leads to bypass of G0/G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 blocks p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Protein–protein interfaces: mimics and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Regulation of lymphocyte survival by the bcl-2 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Perspectives on the development of a molecularly targeted agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Induction of apoptosis in fibroblasts by c-myc protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

bcl-2 transgene expression can protect neurons against developmental and induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Organelle-specific initiation of cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Insights into programmed cell death through structural biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis in cancer therapy: crossing the threshold

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Humanin peptide suppresses apoptosis by interfering with Bax activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

High-throughput nuclear magnetic resonance-based screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Differential requirement for caspase 9 in apoptotic pathways in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax, along with lipid conspirators, allows cytochrome c to escape mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Adult Apaf-1-deficient mice exhibit male infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 family proteins as targets for anticancer drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis: a link between cancer genetics and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

An electron-microscope study of liver cell necrosis due to heliotrine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The harlequin mouse mutation downregulates apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BCL-2 cooperates with promyelocytic leukemia retinoic acid receptor alpha chimeric protein (PMLRARalpha) to block neutrophil differentiation and initiate acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Structure-based strategies for drug design and discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Sequential bcl-2 and c-myc oncogene rearrangements associated with the clinical transformation of non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The p53 tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Endonuclease G is an apoptotic DNase when released from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BCL2 translocation frequency rises with age in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Programmed cell death and apoptosis: origins of the theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Breaking the mitochondrial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Mitochondria-dependent apoptosis and cellular pH regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Developmental regulation of the bcl-2 family during spermatogenesis: insights into the sterility of bcl-w-/- male mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

From bench to clinic with apoptosis-based therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Selective regulation ofBcl-XLby a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Mitochondrial endonuclease G is important for apoptosis in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Solution structure of the antiapoptotic protein bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Mouse models of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis-based therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apoptosis-targeted therapies for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Testicular degeneration in Bclw-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A view to a kill: ligands for Bcl-2 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Differences between CD95 type I and II cells detected with the CD95 ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The INK4a/ARF network in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Mechanisms of caspase activation and inhibition during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Regulation of apoptosis by endoplasmic reticulum pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 over-expression reduces growth rate and prolongs G1 phase in continuous chemostat cultures of hybridoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Direct addition of BimL to mitochondria does not lead to cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

21 January 2018

Caspases: Enemies Within

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

VDAC regulation by the Bcl-2 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Phosphorylation of the pro-apoptotic protein BIK: mapping of phosphorylation sites and effect on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-2 targets the protein kinase Raf-1 to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BID: a novel BH3 domain-only death agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

TRAIL and apoptosis induction by TNF-family death receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Movement of Bax from the Cytosol to Mitochondria during Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Ion homeostasis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Role of BAX in the apoptotic response to anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Proapoptotic BID is required for myeloid homeostasis and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

A Matter of Life and Cell Death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

An E mu-BCL-2 transgene facilitates leukaemogenesis by ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Discovering High-Affinity Ligands for Proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Ultrastructural localization of bcl-2 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Interaction, assembly and processing at the chemistry—biology interface

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021

Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207102

7 January 2021