Thom Award Lecture. Trends in the search for bioactive microbial metabolites (Q35302718)

7 August 2017

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title

Thom Award Lecture. Trends in the search for bioactive microbial metabolites (English)

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7 August 2017

S. Omura

1

1 reference

PubMed ID

1368867

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1368867

19 September 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

PubMed ID

1368867

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1368867

19 September 2022

publication date

1 September 1992

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Journal of Industrial Microbiology & Biotechnology

7 August 2017

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7 August 2017

10

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7 August 2017

135-156

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7 August 2017

3-4

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Gastrointestinal motor-stimulating activity of macrolide antibiotics and analysis of their side effects on the canine gut

7 August 2017

1 reference

https://api.crossref.org/works/10.1007%2FBF01569759

Pradimicins A, B and C: new antifungal antibiotics. II. In vitro and in vivo biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01569759

A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01569759

Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01569759

"Streptomyces avermitilis" mutants defective in methylation of avermectins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01569759

Potent and specific inhibitors of protein kinase C of microbial origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01569759

Inhibition of acyl-CoA synthetase by triacsins

21 January 2018

1 reference

12 December 2020

Philosophy of new drug discovery

1 reference

12 December 2020

Structures of jietacines: unique alpha,beta-unsaturated azoxy antibiotics

1 reference

12 December 2020

Kitasatosporia, a genus of the order Actinomycetales

1 reference

12 December 2020

Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase

1 reference

12 December 2020

F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase

1 reference

12 December 2020

Novel cytocidal antibiotics, glucopiericidinols A1 and A2. Taxonomy, fermentation, isolation, structure elucidation and biological characteristics.

1 reference

12 December 2020

Antibiotics from basidiomycetes. XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty

1 reference

12 December 2020

The erythromycin derivative EM-523 is a potent motilin agonist in man and in rabbit

1 reference

12 December 2020

28 Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

1 reference

12 December 2020

New antifungal antibiotics, benanomicins A and B from an Actinomycete

1 reference

12 December 2020

A deacylation enzyme for aculeacin A, a neutral lipopeptide antibiotic, from Actinoplanes utahensis: purification and characterization

1 reference

12 December 2020

Nannochelins A, B and C, new iron-chelating compounds from Nannocystis exedens (myxobacteria). Production, isolation, physico-chemical and biological properties

1 reference

12 December 2020

Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.

1 reference

12 December 2020

Nerve growth factor and Alzheimer's disease

1 reference

12 December 2020

Selective production of specific components of avermectins in Streptomyces avermitilis.

1 reference

12 December 2020

Inhibition of platelet aggregation by medermycin and it's related isochromanequinone antibiotics

1 reference

12 December 2020

The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp

1 reference

12 December 2020

Studies on a novel antitumor antibiotic, phenazinomycin: taxonomy, fermentation, isolation, and physicochemical and biological characteristics.

1 reference

12 December 2020

Synthesis of new analogs of echinocandin B by enzymatic deacylation and chemical reacylation of the echinocandin B peptide: synthesis of the antifungal agent cilofungin (LY121019)

1 reference

12 December 2020

Calcofluor white ST Alters the in vivo assembly of cellulose microfibrils

1 reference

12 December 2020

F-244 (1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase: taxonomy of producing strain, fermentation, isolation and biological properties.

1 reference

12 December 2020

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1 reference

12 December 2020

afsB stimulates transcription of the actinorhodin biosynthetic pathway in Streptomyces coelicolor A3(2) and Streptomyces lividans

1 reference

12 December 2020

The structure and cytocidal activity of herbimycin C

1 reference

12 December 2020

Characteristic motor activity of the gastrointestinal tract in fasted conscious dogs measured by implanted force transducers

1 reference

12 December 2020

The pre-S region of hepadnavirus envelope proteins

1 reference

12 December 2020

Stabilization of blood platelet microtubular system by staurosporine

1 reference

12 December 2020

Protein kinase inhibitors and blood pressure control in spontaneously hypertensive rats

1 reference

12 December 2020

7-Hydro-8-methylpteroylglutamylglutamic acid, a new anti-folate from an actinomycete. Fermentation, isolation, structure and biological activity

1 reference

12 December 2020

New strategy for discovery of enzyme inhibitors: screening with intact mammalian cells or intact microorganisms having special functions

1 reference

12 December 2020

Herbimycin B, a new benzoquinonoid ansamycin with anti-TMV and herbicidal activities

1 reference

12 December 2020

Dactinomycin is a competitive neurokinin-2 receptor antagonist

1 reference

12 December 2020

Microbial hydroxylation of ML-236B (compactin) and monacolin K (MB-530B)

1 reference

12 December 2020

A new antibiotic, 13-hydroxyglucopiericidin A. Isolation, structure elucidation and biological characteristics

1 reference

12 December 2020

Aggreceride, a new platelet aggregation inhibitor from Streptomyces

1 reference

12 December 2020

Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells

1 reference

12 December 2020

Heterogeneity of ribosomal proteins among Streptomyces species and its application to identification.

1 reference

12 December 2020

Propioxatins A and B, new enkephalinase B inhibitors. I. Taxonomy, fermentation, isolation and biological properties.

1 reference

12 December 2020

Triacsins, new inhibitors of acyl-CoA synthetase produced by Streptomyces sp

1 reference

12 December 2020

Motilin, a Gastric Motor Activity Stimulating Polypeptide: The Complete Amino Acid Sequence

1 reference

12 December 2020

Involvement of long-chain acyl coenzyme A for lipid synthesis in repression of acetyl-coenzyme A carboxylase in Candida lipolytica

1 reference

12 December 2020

An erythromycin derivative, EM-523, induces motilin-like gastrointestinal motility in dogs

1 reference

12 December 2020

Microbial Metabolites as Potentially useful Pharmacologically active Agents

1 reference

12 December 2020

The use of beta-galactosidase gene fusions to screen for antibacterial antibiotics.

1 reference

12 December 2020

Enhanced antimicrobial activity of acetyl derivatives of cervinomycin

1 reference

12 December 2020

Microbial transformation of azacarbazoles. I. N-methylation of alpha-, beta-, and gamma-carbolines by Kitasatosporia setae strain

1 reference

12 December 2020

Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

1 reference

12 December 2020

Hypolipidemic activity of rifamycin derivatives

1 reference

12 December 2020

Antibiotic 1233A: a fungal β-lactone

1 reference

12 December 2020

Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor

1 reference

12 December 2020

Production of ‘hybrid’ antibiotics by genetic engineering

1 reference

12 December 2020

Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics

1 reference

12 December 2020

OM-4842, a new platelet aggregation inhibitor from Streptomyces

1 reference

12 December 2020

Trophic factors and neuronal survival

1 reference

12 December 2020

Isoxaben Inhibits the Synthesis of Acid Insoluble Cell Wall Materials In Arabidopsis thaliana.

1 reference

12 December 2020

Lustromycin, a new antibiotic produced by Streptomyces sp

1 reference

12 December 2020

Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. I. Production, isolation and physico-chemical and biological properties

1 reference

12 December 2020

An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.

1 reference

12 December 2020

Cloning and sequencing of the aculeacin A acylase-encoding gene from Actinoplanes utahensis and expression in Streptomyces lividans

1 reference

12 December 2020

Izupeptins A and B, new glycopeptide antibiotics produced by an actinomycete.

1 reference

12 December 2020

Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells

1 reference

12 December 2020

Pharmacologically Active Compounds from Microbial Origin

1 reference

12 December 2020

Ahpatinins, new acid protease inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid

1 reference

12 December 2020

Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.

1 reference

12 December 2020

Phthoramycin, a new antibiotic active against a plant pathogen, Phytophthora sp

1 reference

12 December 2020

Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation

1 reference

12 December 2020

Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties

1 reference

12 December 2020

Biosynthesis of cellulose.

1 reference

12 December 2020

Isolation and characterization of terpentecin, a new antitumor antibiotic

1 reference

12 December 2020

Phthoxazolin, a specific inhibitor of cellulose biosynthesis, produced by a strain of Streptomyces sp

1 reference

12 December 2020

Type of diaminopimelic acid different in aerial and vegetative mycelia of setamycin-producing actinomycete KM-6054

1 reference

12 December 2020

A selective isolation procedure for Micromonospora.

1 reference

12 December 2020

Triacsin C: a differential inhibitor of arachidonoyl-CoA synthetase and nonspecific long chain acyl-CoA synthetase

1 reference

12 December 2020

Globopeptin, a new antifungal peptide antibiotic

1 reference

12 December 2020

Amino acid biosynthesis inhibitors as herbicides

1 reference

12 December 2020

Propionyl erythromycin. A review of 20,525 case reports for side effect data

1 reference

12 December 2020

Powerful antiangiogenic activity of herbimycin A (named angiostatic antibiotic).

1 reference

12 December 2020

Erythromycin and its derivatives with motilin-like biological activities inhibit the specific binding of 125I-motilin to duodenal muscle

1 reference

12 December 2020

A new antibiotic, okicenone. II. Physico-chemical properties and structure elucidation

1 reference

12 December 2020

Regulation of nerve growth factor content in a neuroblastoma cell line

1 reference

12 December 2020

Deacylation of echinocandin B by Actinoplanes utahensis

1 reference

12 December 2020

Purpactins, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium purpurogenum. III. Chemical modification of purpactin A.

1 reference

12 December 2020

Naturally occurring monobactams

1 reference

12 December 2020

Studies on aculeacin. I. Isolation and characterization of aculeacin A

1 reference

12 December 2020

Use of erbstatin as protein-tyrosine kinase inhibitor

1 reference

12 December 2020

Antitumor activity of a new antibiotic, kazusamycin

1 reference

12 December 2020

Ilotycin, a new antibiotic

1 reference

12 December 2020

A new antitumor antibiotic, kazusamycin

1 reference

12 December 2020

Genetic studies of avermectin biosynthesis in Streptomyces avermitilis

1 reference

12 December 2020

Structural study of isoflavonoids possessing antioxidant activity isolated from the fermentation broth of Streptomyces sp.

1 reference

12 December 2020

Taxonomic properties of five Kitasatosporia strains isolated by a new method

1 reference

12 December 2020

Staurosporine, a protein kinase inhibitor, attenuates intracellular Ca2+ -dependent contractions of strips of rabbit aorta

1 reference

12 December 2020

Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules

1 reference

12 December 2020

Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation

1 reference

12 December 2020

EM-523, an erythromycin derivative, and motilin show similar contractile activity in isolated rabbit intestine.

1 reference

12 December 2020

Antitumor spectrum of deoxyspergualin and its lack of cross-resistance to other antitumor agents.

1 reference

12 December 2020

Sequence-specific 1H NMR assignments and secondary structure of porcine motilin

1 reference

12 December 2020

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity

1 reference

12 December 2020

Setamycin, a new antibiotic

1 reference

12 December 2020

Tetracycline administration normalizes the structure and acid phosphatase activity of osteoclasts in streptozotocin-induced diabetic rats

1 reference

12 December 2020

Selective production of specific components of avermectins in Streptomyces avermitilis.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.44.560

Novel antibiotics, furaquinocins A and B. Taxonomy, fermentation, isolation and physico-chemical and biological characteristics.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.43.247

Propioxatins A and B, new enkephalinase B inhibitors. I Taxonomy, fermentation, isolation and biological properties.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.39.1368

A novel trehalase inhibitor, trehalostatin, produced by Amycolatopsis trehalostatica HG-25.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1271/BBB1961.55.895

A novel proteinase inhibitor, tyrostatin, inhibiting some pepstatin-insensitive carboxyl proteinases.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1271/BBB1961.53.405

Identifiers

DOI

10.1007/BF01569759

1 reference

7 August 2017

1 reference

PubMed ID

1368867