Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants (Q35221149)

7 August 2017

title

Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants (English)

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7 August 2017

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Thomas G Graeber

12

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author name string

Brian J Skaggs

1

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7 August 2017

Mercedes E Gorre

2

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7 August 2017

Ann Ryvkin

3

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7 August 2017

Michael R Burgess

4

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7 August 2017

Yongming Xie

5

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7 August 2017

Yun Han

6

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7 August 2017

Evangelia Komisopoulou

7

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7 August 2017

Lauren M Brown

8

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7 August 2017

Joseph A Loo

9

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7 August 2017

Elliot M Landaw

10

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7 August 2017

Charles L Sawyers

11

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7 August 2017

publication date

12 December 2006

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Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

language of work or name

English

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published in

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7 August 2017

volume

103

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7 August 2017

issue

51

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7 August 2017

page(s)

19466-19471

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Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib

7 August 2017

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13 July 2018

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13 July 2018

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13 July 2018

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

13 July 2018

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Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

13 July 2018

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Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment.

13 July 2018

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13 July 2018

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13 July 2018

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The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

13 July 2018

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13 July 2018

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An activating mutation in the ATP binding site of the ABL kinase domain.

13 July 2018

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Use of synthetic peptide libraries and phosphopeptide-selective mass spectrometry to probe protein kinase substrate specificity.

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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26 September 2018

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26 September 2018

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26 September 2018

1 reference

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26 September 2018

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Sensitive and quantitative detection of mutations associated with clinical resistance to STI-571.

26 September 2018

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A mutation conferring resistance to imatinib at the time of diagnosis of chronic myelogenous leukemia.

26 September 2018

1 reference

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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

26 September 2018

1 reference

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Resistance to tumor specific therapy with imatinib by clonal selection of mutated cells

26 September 2018

1 reference

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Mutation in the ATP-binding site of BCR-ABL in a patient with chronic myeloid leukaemia with increasing resistance to STI571.

26 September 2018

1 reference

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Engineering Src family protein kinases with unnatural nucleotide specificity

26 September 2018

1 reference

12 December 2020

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow

1 reference

12 December 2020

Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107)

1 reference

12 December 2020

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

1 reference

12 December 2020

Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0609239103

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7 August 2017

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7 August 2017

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