Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis (Q35210772)

7 August 2017

title

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis (English)

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7 August 2017

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I Schwarte-Waldhoff

1

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7 August 2017

O V Volpert

2

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7 August 2017

N P Bouck

3

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7 August 2017

B Sipos

4

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7 August 2017

S A Hahn

5

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7 August 2017

S Klein-Scory

6

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7 August 2017

J Lüttges

7

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7 August 2017

G Klöppel

8

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7 August 2017

U Graeven

9

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7 August 2017

C Eilert-Micus

10

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7 August 2017

A Hintelmann

11

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7 August 2017

W Schmiegel

12

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7 August 2017

publication date

1 August 2000

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Proceedings of the National Academy of Sciences of the United States of America

7 August 2017

language of work or name

English

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published in

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7 August 2017

volume

97

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7 August 2017

issue

17

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7 August 2017

page(s)

9624-9629

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TGF-beta signalling through the Smad pathway

7 August 2017

cites work

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13 July 2018

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Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling

13 July 2018

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13 July 2018

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Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

13 July 2018

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Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells

13 July 2018

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Genetic events and the role of TGF beta in epithelial tumour progression

13 July 2018

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Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization

13 July 2018

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G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: phenotypes reversed by a tumorigenic mutation

13 July 2018

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Inactivation of the p53 tumor suppressor gene via a novel Alu rearrangement

13 July 2018

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TGF-beta signal transduction

13 July 2018

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Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

13 July 2018

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Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

13 July 2018

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Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

13 July 2018

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Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

13 July 2018

1 reference

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Mutations in the SMAD4/DPC4 gene in juvenile polyposis

13 July 2018

1 reference

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Mads and Smads in TGFβ signalling

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Mutations of the DPC4/Smad4 gene in biliary tract carcinoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Role of Growth Factors in Pancreatic Cancer

13 July 2018

1 reference

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Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads

13 July 2018

1 reference

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13 July 2018

TGF-β receptor signaling

1 reference

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

General mechanisms of metastasis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-β through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

The von Hippel-Lindau Tumor Suppressor Gene Product Interacts with Sp1 To Repress Vascular Endothelial Growth Factor Promoter Activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Characterization of functional domains within Smad4/DPC4

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

How tumors become angiogenic

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition

13 July 2018

1 reference

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

13 July 2018

1 reference

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Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Functional identification and molecular cloning of a rat gene mediating growth inhibition and programmed cell death in normal and transformed rat cell lines

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Assay and purification of naturally occurring inhibitor of angiogenesis

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Transforming growth factor-beta: recent progress and new challenges

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=16915

Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients

26 September 2018

1 reference

12 December 2020

Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression

1 reference

12 December 2020

Mutations of the DPC4/Smad4 gene in neuroendocrine pancreatic tumors

1 reference

12 December 2020

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

1 reference

12 December 2020

Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity

1 reference

12 December 2020

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression

1 reference

12 December 2020

DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression

1 reference

12 December 2020

Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells

1 reference

12 December 2020

Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis

1 reference

12 December 2020

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1 reference

12 December 2020

DPC4 gene in various tumor types

1 reference

12 December 2020

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression

1 reference

12 December 2020

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.97.17.9624

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7 August 2017

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7 August 2017

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