'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass? (Q35210020)

7 August 2017

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title

'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass? (English)

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7 August 2017

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Louis M Luttrell

2

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author name string

Diane Gesty-Palmer

series ordinal

1

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PubMed ID

21506957

7 August 2017

language of work or name

English

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publication date

1 September 2011

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British Journal of Pharmacology

7 August 2017

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7 August 2017

164

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7 August 2017

59-67

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7 August 2017

1

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Beyond desensitization: physiological relevance of arrestin-dependent signaling.

7 August 2017

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

13 July 2018

1 reference

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A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice.

13 July 2018

1 reference

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Growth hormone, insulin-like growth factors, and the skeleton

13 July 2018

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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

13 July 2018

1 reference

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Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis.

13 July 2018

1 reference

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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

13 July 2018

1 reference

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The origins of diversity and specificity in g protein-coupled receptor signaling

13 July 2018

1 reference

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beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice

13 July 2018

1 reference

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Parathyroid hormone: a double-edged sword for bone metabolism

13 July 2018

1 reference

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Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization

13 July 2018

1 reference

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

13 July 2018

1 reference

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

13 July 2018

1 reference

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The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks

13 July 2018

1 reference

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Regulation of G protein-coupled receptor signaling by scaffold proteins

13 July 2018

1 reference

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Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling

13 July 2018

1 reference

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Definition of the molecular and cellular mechanisms underlying the tissue-selective agonist/antagonist activities of selective estrogen receptor modulators

13 July 2018

1 reference

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G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction

13 July 2018

1 reference

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Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking

13 July 2018

1 reference

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Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling

13 July 2018

1 reference

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Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone is protein kinase C-dependent.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Enhanced morphine analgesia in mice lacking beta-arrestin 2

13 July 2018

1 reference

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Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy

13 July 2018

1 reference

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3',5'-Cyclic adenosine monophosphate activation in osteoblastic cells: effects on parathyroid hormone-1 receptors and osteoblastic differentiation in vitro

13 July 2018

1 reference

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RAMPs: accessory proteins for seven transmembrane domain receptors

13 July 2018

1 reference

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

13 July 2018

1 reference

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Molecular mechanism of action of fluoride on bone cells

13 July 2018

1 reference

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Parathyroid hormone-related protein increases DNA synthesis in proximal tubule cells by cyclic AMP- and protein kinase C-dependent pathways.

13 July 2018

1 reference

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Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process.

13 July 2018

1 reference

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Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells

13 July 2018

1 reference

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Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras.

13 July 2018

1 reference

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The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy

13 July 2018

1 reference

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Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Small bone-building fragments of parathyroid hormone: new therapeutic agents for osteoporosis

13 July 2018

1 reference

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The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

13 July 2018

1 reference

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Prostaglandin F2 alpha-induced mitogenesis in MC3T3-E1 osteoblasts: role of protein kinase-C-mediated tyrosine phosphorylation

13 July 2018

1 reference

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G protein-coupled receptor kinases

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Agonist-receptor efficacy. II. Agonist trafficking of receptor signals

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

On the analysis of pharmacological experiments in terms of an allosteric receptor model.

13 July 2018

1 reference

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Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

13 July 2018

1 reference

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The protein kinase-C activation domain of the parathyroid hormone

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3171860

Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases in

13 July 2018

1 reference

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Health care utilization and expenditures in the United States: a study of osteoporosis-related fractures.

13 July 2018

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Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

21 January 2018

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Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01450.X

Effect of low-dose of recombinant human growth hormone on bone metabolism in elderly women with osteoporosis

21 January 2018

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Parathyroid hormone stimulates extracellular signal-regulated kinase (ERK) activity through two independent signal transduction pathways: role of ERK in sodium-phosphate cotransport

21 January 2018

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12 December 2020

Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations

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12 December 2020

Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration

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12 December 2020

Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2

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12 December 2020

Further definition of the protein kinase C activation domain of the parathyroid hormone

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12 December 2020

Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells

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12 December 2020

Intermittent parathyroid hormone treatment increases osteoblast number, steady state messenger ribonucleic acid levels for osteocalcin, and bone formation in tibial metaphysis of hypophysectomized female rats

1 reference

12 December 2020

Structurally diverse N-terminal peptides of parathyroid hormone (PTH) and PTH-related peptide (PTHRP) inhibit the Na+/H+ exchanger NHE3 isoform by binding to the PTH/PTHRP receptor type I and activating distinct signaling pathways

1 reference

12 December 2020

10.1111/J.1476-5381.2011.01450.X

Identifiers

DOI

1 reference

7 August 2017

1 reference

7 August 2017

1 reference

PubMed ID

21506957