Pharmacophylogenomics: genes, evolution and drug targets (Q35194747)

7 August 2017

title

Pharmacophylogenomics: genes, evolution and drug targets (English)

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7 August 2017

David B Searls

1

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7 August 2017

publication date

1 August 2003

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Nature Reviews Drug Discovery

7 August 2017

language of work or name

English

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published in

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7 August 2017

volume

2

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7 August 2017

issue

8

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7 August 2017

page(s)

613-623

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publication type of scholarly work

7 August 2017

review article

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Gastrogenomic delights: a movable feast

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Molecular evolution of FOXP2, a gene involved in speech and language

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Speech disorder in schizophrenia: review of the literature and exploration of its relation to the uniquely human capacity for language

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Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

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Evidence for purifying selection acting on silent sites in BRCA1

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Vertebrate evolution: doubling and shuffling with a full deck

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Segmental duplications and the evolution of the primate genome

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The temporal distribution of gene duplication events in a set of highly conserved human gene families

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Alternative splicing and genome complexity

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Role of duplicate genes in genetic robustness against null mutations

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Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative.

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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

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The tissue-specific, compensatory expression of cyclooxygenase-1 and -2 in transgenic mice

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Cytokines and related receptor-mediated signaling pathways

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Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits

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Evolution of enzymes in metabolism: a network perspective.

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Homology among (betaalpha)(8) barrels: implications for the evolution of metabolic pathways

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Changes in glycolytic network and mitochondrial design in creatine kinase-deficient muscles

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Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

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A simple dependence between protein evolution rate and the number of protein-protein interactions

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Phylogenetic shadowing of primate sequences to find functional regions of the human genome

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Distinguishing Homologous from Analogous Proteins

31 March 2020

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Synonymous and non-synonymous mutations in a region of the Plasmodium chabaudi genome and evidence for selection acting on a malaria vaccine candidate

31 March 2020

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Biological and biomedical implications of the co-evolution of pathogens and their hosts

31 March 2020

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Intra- and interspecific variation in primate gene expression patterns

31 March 2020

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Systematic determination of genetic network architecture

31 March 2020

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Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin

31 March 2020

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A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules

31 March 2020

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Can We Learn To Distinguish between “Drug-like” and “Nondrug-like” Molecules?

31 March 2020

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Simple selection criteria for drug-like chemical matter

31 March 2020

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

31 March 2020

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Molecular properties that influence the oral bioavailability of drug candidates

31 March 2020

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31 March 2020

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Evolution of human hypoxia tolerance physiology

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1152

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7 August 2017

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