Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. (Q35047056)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12531385%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

title

Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates (English)

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16 December 2019

1

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16 December 2019

author name string

Youri I Pavlov

series ordinal

2

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16 December 2019

Katarzyna Bebenek

series ordinal

3

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16 December 2019

publication date

1 February 2003

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16 December 2019

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16 December 2019

volume

2

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16 December 2019

issue

2

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16 December 2019

page(s)

135-149

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publication type of scholarly work

16 December 2019

review article

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The Y-family of DNA polymerases

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Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass

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Error-prone repair DNA polymerases in prokaryotes and eukaryotes

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

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hRAD30 mutations in the variant form of xeroderma pigmentosum

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Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

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Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

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Error-prone DNA polymerases: novel structures and the benefits of infidelity

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Proofreading of DNA polymerase eta-dependent replication errors

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Interaction with PCNA is essential for yeast DNA polymerase eta function

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Physical and functional interactions of human DNA polymerase eta with PCNA

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Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

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Mutator effects of overproducing DNA polymerase eta (Rad30) and its catalytically inactive variant in yeast

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Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene

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Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).

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trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases

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7 January 2021

Expression of human and mouse genes encoding polkappa: testis-specific developmental regulation and AhR-dependent inducible transcription

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7 January 2021

Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta

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7 January 2021

Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota

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7 January 2021

Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

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7 January 2021

Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota

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7 January 2021

Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene

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7 January 2021

Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

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7 January 2021

Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

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7 January 2021

Fidelity of DNA synthesis

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7 January 2021

DNA replication fidelity

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7 January 2021

DNA lesion bypass polymerases open up.

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7 January 2021

A reexamination of the nucleotide incorporation fidelity of DNA polymerases

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7 January 2021

Active site tightness and substrate fit in DNA replication

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7 January 2021

Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication

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7 January 2021

Low fidelity DNA synthesis by human DNA polymerase-eta

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7 January 2021

Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro

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7 January 2021

Fidelity of human DNA polymerase eta

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7 January 2021

Translesion synthesis by human DNA polymerase eta across thymine glycol lesions

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7 January 2021

Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct

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7 January 2021

Mismatch extension ability of yeast and human DNA polymerase eta

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7 January 2021

Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini

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Error rate and specificity of human and murine DNA polymerase eta

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Streisinger revisited: DNA synthesis errors mediated by substrate misalignments

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Replication of template-primers containing propanodeoxyguanosine by DNA polymerase beta. Induction of base pair substitution and frameshift mutations by template slippage and deoxynucleoside triphosphate stabilization

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7 January 2021

Fidelity of Escherichia coli DNA polymerase IV. Preferential generation of small deletion mutations by dNTP-stabilized misalignment

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Low fidelity DNA synthesis by a y family DNA polymerase due to misalignment in the active site.

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5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro

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7 January 2021

Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair

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7 January 2021

Identification of 5′-deoxyribose phosphate lyase activity in human DNA polymerase γ and its role in mitochondrial base excision repair in vitro

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7 January 2021

Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polymerase lambda: a possible role in base excision repair

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7 January 2021

Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation

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7 January 2021

Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.

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7 January 2021

Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase beta

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7 January 2021

Base substitution specificity of DNA polymerase beta depends on interactions in the DNA minor groove

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7 January 2021

Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment)

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7 January 2021

Discrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation

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7 January 2021

Release of normal bases from intact DNA by a native DNA repair enzyme

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7 January 2021

Active-site clashes prevent the human 3-methyladenine DNA glycosylase from improperly removing bases

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7 January 2021

Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs

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Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

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7 January 2021

Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines

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7 January 2021

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

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7 January 2021

Immunoglobulin genes: generating diversity with AID and UNG.

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7 January 2021

AID and mismatch repair in antibody diversification

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7 January 2021

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

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Somatic mutation hotspots correlate with DNA polymerase eta error spectrum

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Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots

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7 January 2021

Both DNA strands of antibody genes are hypermutation targets

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7 January 2021

The Targeting of Somatic Hypermutation Closely Resembles That of Meiotic Mutation

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7 January 2021

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

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7 January 2021

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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7 January 2021

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

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7 January 2021

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

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7 January 2021

Emerging links between hypermutation of antibody genes and DNA polymerases

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7 January 2021

Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

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7 January 2021

DNA polymerase mu, a candidate hypermutase?

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7 January 2021

Transcription, beta-like DNA polymerases and hypermutation

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7 January 2021

Highly frequent frameshift DNA synthesis by human DNA polymerase mu

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7 January 2021

Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation

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7 January 2021

Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase

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7 January 2021

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

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7 January 2021

Error-prone candidates vie for somatic mutation

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7 January 2021

Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.

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Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

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7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

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7 January 2021

A novel cytidine deaminase affects antibody diversity

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7 January 2021

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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7 January 2021

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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7 January 2021

The AID enzyme induces class switch recombination in fibroblasts

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7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

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7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

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7 January 2021

A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes

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7 January 2021

Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps

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7 January 2021

Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA

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7 January 2021

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

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7 January 2021

10.1016/S1568-7864(02)00224-0

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12531385%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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