A fully human inhibitory monoclonal antibody to the Wnt receptor RYK (Q34995094)

5 August 2017

title

A fully human inhibitory monoclonal antibody to the Wnt receptor RYK (English)

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5 August 2017

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5

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5 August 2017

Maria L Macheda

2

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Clare L Parish

object named as

Clare L Parish

3

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Steven A Stacker

object named as

Steven A Stacker

8

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author name string

Michael M Halford

1

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5 August 2017

Elena A Takano

4

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5 August 2017

Daniel Layton

6

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5 August 2017

Edouard Nice

7

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5 August 2017

language of work or name

English

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publication date

18 September 2013

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5 August 2017

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5 August 2017

volume

8

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5 August 2017

issue

9

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5 August 2017

page(s)

e75447

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Creative Commons Attribution 4.0 International

5 August 2017

copyright license

start time

18 September 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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WNT5 interacts with the Ryk receptors doughnut and derailed to mediate muscle attachment site selection in Drosophila melanogaster

8 July 2018

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Noncanonical Wnt signaling promotes osteoclast differentiation and is facilitated by the human immunodeficiency virus protease inhibitor ritonavir

8 July 2018

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Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling

8 July 2018

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Antagonism of LIN-17/Frizzled and LIN-18/Ryk in nematode vulva induction reveals evolutionary alterations in core developmental pathways

8 July 2018

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Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

8 July 2018

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Wnt5a regulates midbrain dopaminergic axon growth and guidance

8 July 2018

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Production of lentiviral vectors in protein-free media

8 July 2018

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The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development.

8 July 2018

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Targeting non-malignant disorders with tyrosine kinase inhibitors.

8 July 2018

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Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem

8 July 2018

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Pseudokinases-remnants of evolution or key allosteric regulators?

8 July 2018

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Wnt/calcium signaling mediates axon growth and guidance in the developing corpus callosum

8 July 2018

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Wnt5b-Ryk pathway provides directional signals to regulate gastrulation movement.

8 July 2018

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Novel research horizons for presenilins and γ-secretases in cell biology and disease

8 July 2018

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Cell signaling by receptor tyrosine kinases

8 July 2018

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Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate

8 July 2018

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Molecular and cellular mechanisms of ectodomain shedding

8 July 2018

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Wnt5a induces simultaneous cortical axon outgrowth and repulsive axon guidance through distinct signaling mechanisms

8 July 2018

1 reference

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Differentially expressed Drl and Drl-2 play opposing roles in Wnt5 signaling during Drosophila olfactory system development

8 July 2018

1 reference

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Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements

8 July 2018

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Opposing Wnt pathways orient cell polarity during organogenesis

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Repulsive Wnt signaling inhibits axon regeneration after CNS injury

8 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

TLR4-dependent lipopolysaccharide-induced shedding of tumor necrosis factor receptors in mouse bone marrow granulocytes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Stimulation of cleavage of membrane proteins by calmodulin inhibitors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Axon routing across the midline controlled by the Drosophila Derailed receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

A new secreted protein that binds to Wnt proteins and inhibits their activities

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases (Ryk).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Properties of pervanadate and permolybdate. Connexin43, phosphatase inhibition, and thiol reactivity as model systems.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

A T7 expression vector for producing N- and C-terminal fusion proteins with glutathione S-transferase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF).

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

8 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Derailed regulates development of the Drosophila neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Wnt4 is a local repulsive cue that determines synaptic target specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Antagonistic roles of Wnt5 and the Drl receptor in patterning the Drosophila antennal lobe

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Wnt-mediated axon guidance via the Drosophila Derailed receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Respective roles of the DRL receptor and its ligand WNT5 in Drosophila mushroom body development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

The Drosophila Wnt5 protein mediates selective axon fasciculation in the embryonic central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Upregulation of Ryk expression in rat dorsal root ganglia after peripheral nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0075447

Wnt-Ryk signalling mediates medial-lateral retinotectal topographic mapping

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

derailed is required for muscle attachment site selection in Drosophila.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3776778

Optimum dissociating condition for immunoaffinity and preferential isolation of antibodies with high specific activity

26 October 2018

1 reference

12 December 2020

The VD1 neutralizing antibody to vascular endothelial growth factor-D: binding epitope and relationship to receptor binding

1 reference

12 December 2020

Overexpression of H-Ryk in epithelial ovarian cancer: prognostic significance of receptor expression

1 reference

12 December 2020

Exploring "one-shot" kinetics and small molecule analysis using the ProteOn XPR36 array biosensor

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0075447

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DOI

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5 August 2017

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5 August 2017

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