Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein (Q34835930)

4 August 2017

title

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein (English)

1 reference

4 August 2017

Lawrence J Marnett

1

1 reference

4 August 2017

James N Riggins

series ordinal

2

1 reference

4 August 2017

James D West

series ordinal

3

1 reference

4 August 2017

publication date

1 March 2003

1 reference

Journal of Clinical Investigation

4 August 2017

language of work or name

English

0 references

published in

1 reference

4 August 2017

volume

111

1 reference

4 August 2017

issue

5

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4 August 2017

page(s)

583-593

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publication type of scholarly work

4 August 2017

review article

1 reference

Mapping the reaction of peroxynitrite with CO2: energetics, reactive species, and biological implications

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8 July 2018

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8 July 2018

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Peroxynitrite-induced nitration of tyrosine hydroxylase: identification of tyrosines 423, 428, and 432 as sites of modification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and tyrosine-scanning mutagenesis

8 July 2018

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Basal and stimulated protein S-nitrosylation in multiple cell types and tissues

8 July 2018

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Proteomic method identifies proteins nitrated in vivo during inflammatory challenge

8 July 2018

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8 July 2018

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8 July 2018

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Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions

8 July 2018

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8 July 2018

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Oxidative modification of proteins during aging

8 July 2018

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Lipid hydroperoxide-mediated DNA damage

8 July 2018

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Free radicals associated with DNA damage

8 July 2018

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Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis

8 July 2018

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Cytokine-induced activation of nuclear factor-kappa B is inhibited by hydrogen peroxide through oxidative inactivation of IkappaB kinase

8 July 2018

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Caspases are reversibly inactivated by hydrogen peroxide

8 July 2018

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Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation

8 July 2018

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Chemistry and biochemistry of oxidative stress in neurodegenerative disease

8 July 2018

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IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal

8 July 2018

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Inhibition of NF-kappa B by S-nitrosylation

8 July 2018

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Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation

8 July 2018

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The NADPH oxidase of endothelial cells

8 July 2018

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Structural basis of the redox switch in the OxyR transcription factor

8 July 2018

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Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade

8 July 2018

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Oxidative biochemical markers; clues to understanding aging in long-lived species

8 July 2018

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Endogenous DNA damage and mutation.

8 July 2018

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Protein S-nitrosylation: a physiological signal for neuronal nitric oxide

8 July 2018

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Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors

8 July 2018

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Evaluation of the mutagenic potential of the principal DNA adduct of acrolein

8 July 2018

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Physiological functions of thioredoxin and thioredoxin reductase

8 July 2018

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Cell signaling by reactive nitrogen and oxygen species in atherosclerosis

8 July 2018

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Myeloperoxidase-generated oxidants and atherosclerosis

8 July 2018

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Role of reactive aldehyde in cardiovascular diseases

8 July 2018

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Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents

8 July 2018

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Etheno-adduct-forming chemicals: from mutagenicity testing to tumor mutation spectra

8 July 2018

1 reference

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Nitrite as a substrate and inhibitor of myeloperoxidase. Implications for nitration and hypochlorous acid production at sites of inflammation

8 July 2018

1 reference

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Analysis of free and protein-bound nitrotyrosine in human plasma by a gas chromatography/mass spectrometry method that avoids nitration artifacts

8 July 2018

1 reference

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Enzymology of the repair of etheno adducts in mammalian cells and in Escherichia coli.

8 July 2018

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Mammalian enzymatic repair of etheno and para-benzoquinone exocyclic adducts derived from the carcinogens vinyl chloride and benzene

8 July 2018

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Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis

8 July 2018

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Chemistry and biology of DNA damage by malondialdehyde.

8 July 2018

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Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

8 July 2018

1 reference

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Comparison of the mutagenic properties of 8-oxo-7,8-dihydro-2'-deoxyadenosine and 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA lesions in mammalian cells

8 July 2018

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Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease

8 July 2018

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Protein-sulfenic acids: diverse roles for an unlikely player in enzyme catalysis and redox regulation

8 July 2018

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Redox regulation of c-Jun DNA binding by reversible S-glutathiolation.

8 July 2018

1 reference

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Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase

8 July 2018

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Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct

8 July 2018

1 reference

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Regulation of PTP1B via glutathionylation of the active site cysteine 215

8 July 2018

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The lipid peroxidation product 4-hydroxynonenal inhibits neurite outgrowth, disrupts neuronal microtubules, and modifies cellular tubulin

8 July 2018

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Fas-induced caspase denitrosylation

8 July 2018

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Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages.

8 July 2018

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The chemistry of DNA damage from nitric oxide and peroxynitrite

8 July 2018

1 reference

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Hydroxyl radicals and DNA base damage

8 July 2018

1 reference

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Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

8 July 2018

1 reference

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Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

8 July 2018

1 reference

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Human Neutrophils Employ Myeloperoxidase To Convert α-Amino Acids to a Battery of Reactive Aldehydes: A Pathway for Aldehyde Generation at Sites of Inflammation

8 July 2018

1 reference

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Nitric oxide mediatesN-methyl-d-aspartate receptor-induced activation of p21ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Inhibition of Caspase-3 by S-Nitrosation and Oxidation Caused by Nitric Oxide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Biochemistry and pathology of radical-mediated protein oxidation

8 July 2018

1 reference

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Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts

8 July 2018

1 reference

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Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols

8 July 2018

1 reference

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Nitrosative stress: activation of the transcription factor OxyR.

8 July 2018

1 reference

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Inhibition of NF-kappaB DNA binding by nitric oxide

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Nitric oxide causes inactivation of the low molecular weight phosphotyrosine protein phosphatase.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for oxidation and transcriptional activation

8 July 2018

1 reference

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Nitric oxide-stimulated guanine nucleotide exchange on p21ras

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

p21 as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Site-specific mutagenesis: retrospective and prospective

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Endogenous oxidative damage of deoxycytidine in DNA.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Artifactual nitration controlled measurement of protein-bound 3-nitro-L-tyrosine in biological fluids and tissues by isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

OxyR: a molecular code for redox-related signaling

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

4,5-Epoxy-2(E)-decenal-induced formation of 1,N(6)-etheno-2'-deoxyadenosine and 1,N(2)-etheno-2'-deoxyguanosine adducts.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Peroxynitrite reacts with 8-nitropurines to yield 8-oxopurines

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tande

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Nitration and inactivation of tyrosine hydroxylase by peroxynitrite

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Chlorination of guanosine and other nucleosides by hypochlorous acid and myeloperoxidase of activated human neutrophils. Catalysis by nicotine and trimethylamine

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

New DNA adducts of crotonaldehyde and acetaldehyde

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Gibbs energy of formation of peroxynitrite--order restored

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

The relative contribution of adduct blockage and DNA repair on template utilization during replication of 1,N2-propanodeoxyguanosine and pyrimido

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

S-nitrosylation: spectrum and specificity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Responses to the major acrolein-derived deoxyguanosine adduct in Escherichia coli

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

DNA adducts: effects of low exposure to ethylene oxide, vinyl chloride and butadiene

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Glyceraldehyde-3-phosphate dehydrogenase inactivation by peroxynitrite

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

The inactivation mechanism of low molecular weight phosphotyrosine-protein phosphatase by H2O2.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Measurement of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 8-oxo-7,8-dihydroguanine in isolated DNA exposed to gamma radiation in aqueous solution.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151910

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

26 October 2018

1 reference

12 December 2020

Monitoring reactions of nitric oxide with peptides and proteins by electrospray ionization-mass spectrometry

1 reference

12 December 2020

Replication Inhibition and Miscoding Properties of DNA Templates Containing a Site-Specific cis-Thymine Glycol or Urea Residue

1 reference

12 December 2020

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

1 reference

12 December 2020

Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis

1 reference

12 December 2020

Nitric Oxide Inhibits Caspase-3 byS-Nitrosationin Vivo

1 reference

12 December 2020

Nitric oxide-induced S-glutathionylation and inactivation of glyceraldehyde-3-phosphate dehydrogenase

1 reference

12 December 2020

Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment

1 reference

12 December 2020

A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction

1 reference

12 December 2020

Inhibition of AP-1 DNA binding by nitric oxide involving conserved cysteine residues in Jun and Fos

1 reference

12 December 2020

Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues

1 reference

12 December 2020

1 reference

12 December 2020

Epidermal growth factor receptor is modulated by redox through multiple mechanisms. Effects of reductants and H2O2

1 reference

12 December 2020

Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination

1 reference

12 December 2020

Mutation spectra induced by replication of two vicinal oxidative DNA lesions in mammalian cells

1 reference

12 December 2020

Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction

1 reference

12 December 2020

Redox regulation of fos and jun DNA-binding activity in vitro

1 reference

12 December 2020

Nitric oxide-induced blockade of NMDA receptors

1 reference

12 December 2020

Nitric Oxide Inhibits c-Jun DNA Binding by Specifically TargetedS-Glutathionylation

1 reference

12 December 2020

Mass spectrometric analysis of nitric oxide-modified caspase-3

1 reference

12 December 2020

Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite

1 reference

12 December 2020

Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein-tyrosine phosphatase 1B

1 reference

12 December 2020

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

1 reference

12 December 2020

Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction

1 reference

12 December 2020

Translesional synthesis on DNA templates containing 8-oxo-7,8-dihydrodeoxyadenosine

1 reference

12 December 2020

S-thiolation of glyceraldehyde-3-phosphate dehydrogenase induced by the phagocytosis-associated respiratory burst in blood monocytes

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI200318022

1 reference

4 August 2017

1 reference

4 August 2017

1 reference