The molecular and genetic basis of neurological tumours (Q34770308)

4 August 2017

title

The molecular and genetic basis of neurological tumours (English)

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4 August 2017

Yuan Zhu

1

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4 August 2017

Luis F Parada

series ordinal

2

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4 August 2017

publication date

1 August 2002

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4 August 2017

language of work or name

English

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published in

Nature Reviews Cancer

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4 August 2017

volume

2

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4 August 2017

issue

8

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4 August 2017

page(s)

616-626

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publication type of scholarly work

4 August 2017

review article

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Malignant glioma: genetics and biology of a grave matter.

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CNTF and its receptor subunits in human gliomas

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Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas.

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Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop

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PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

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Developmental expression of platelet-derived growth factor alpha-receptor in neurons and glial cells of the mouse CNS.

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Guidance of cell migration by the Drosophila PDGF/VEGF receptor

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Proliferation of human malignant astrocytomas is dependent on Ras activation

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Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas.

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Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma

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To cycle or not to cycle: a critical decision in cancer.

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Molecular Genetic Correlates of p16, cdk4, and pRb Immunohistochemistry in Glioblastomas

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Amplification and expression of cyclin D genes (CCND1, CCND2 and CCND3) in human malignant gliomas

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

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A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

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The INK4a/ARF network in tumour suppression

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Amplification of the epidermal-growth-factor-receptor gene correlates with different growth behaviour in human glioblastoma.

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Association of EGFR Gene Amplification and CDKN2 (p16/MTS1) Gene Deletion in Glioblastoma Multiforme

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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PTEN (MMAC1) Mutations Are Frequent in Primary Glioblastomas (de novo) but not in Secondary Glioblastomas

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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Signalling through phosphoinositide 3-kinases: the lipids take centre stage

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

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A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

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Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system

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Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo

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Stem cells in the adult mammalian central nervous system

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Mammalian neural stem cells

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The development of neural stem cells

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Adult neurogenesis in mammals: an identity crisis.

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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain

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Astrocytes give rise to new neurons in the adult mammalian hippocampus.

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Neurons derived from radial glial cells establish radial units in neocortex

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Characterization of CNS precursor subtypes and radial glia

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A unified hypothesis on the lineage of neural stem cells

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Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells

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Epidermal growth factor receptor and Ink4a/Arf

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Origin and early development of Schwann cells

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Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells

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Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

31 March 2020

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Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

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Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosis

31 March 2020

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Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

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Confirmation of a double-hit model for the NF1 gene in benign neurofibromas

31 March 2020

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Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1

31 March 2020

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Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models

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Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

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Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

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Mouse models of tumor development in neurofibromatosis type 1

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Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells

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Schwann cells harbor the somatic NF1 mutation in neurofibromas: evidence of two different Schwann cell subpopulations

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Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1

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Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts

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Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons

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Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase

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Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

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Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

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Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis

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TP53 mutations are frequent in malignant NF1 tumors

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Mouse tumor model for neurofibromatosis type 1

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Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas

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Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation

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Expression of p27(kip) and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: the emerging role of p27(kip) in malignant transformation of neurofibromas

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Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

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Cancer gene therapy: fringe or cutting edge?

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Tyrosine kinase inhibitors: from rational design to clinical trials

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Mechanism-based target identification and drug discovery in cancer research

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Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector

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Anticancer drug targets: cell cycle and checkpoint control.

31 March 2020

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Glial cell diversification in the rat optic nerve

31 March 2020

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Visualization of O-2A progenitor cells in developing and adult rat optic nerve by quisqualate-stimulated cobalt uptake

31 March 2020

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Oligodendrocyte population dynamics and the role of PDGF in vivo.

31 March 2020

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The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification

31 March 2020

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Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection

31 March 2020

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Comparative study of p53 gene and protein alterations in human astrocytic tumors

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC866

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Dimensions publication ID

4 August 2017

1019690281

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