RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage (Q34761198)

4 August 2017

title

RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage (English)

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4 August 2017

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Ryo Sakasai

1

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4 August 2017

Randal Tibbetts

series ordinal

2

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4 August 2017

publication date

12 March 2008

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Journal of Biological Chemistry

4 August 2017

language of work or name

English

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published in

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4 August 2017

volume

283

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4 August 2017

issue

20

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4 August 2017

page(s)

13549-13555

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Cell cycle checkpoint signaling through the ATM and ATR kinases

4 August 2017

cites work

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

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p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

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The tandem BRCT domain of 53BP1 is not required for its repair function

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A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

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Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

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53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin.

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

21 January 2018

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53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage

21 January 2018

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RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint

21 January 2018

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Proteasome function is required for DNA damage response and fanconi anemia pathway activation

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21 January 2018

Identifiers

DOI

10.1074/JBC.M710197200

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4 August 2017

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