Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders? (Q34750188)

4 August 2017

title

Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders? (English)

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4 August 2017

2

Pier Paolo Pandolfi

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author name string

Eduardo M Rego

series ordinal

1

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4 August 2017

publication date

1 August 2002

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Trends in Molecular Medicine

4 August 2017

published in

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4 August 2017

volume

8

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4 August 2017

issue

8

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4 August 2017

page(s)

396-405

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publication type of scholarly work

4 August 2017

review article

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Chromosomal translocations in human cancer.

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Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs

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Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia

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Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

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A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG

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A t(10;17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma

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Identifiers

DOI

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4 August 2017

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