CD4+ CD25+ suppressor T cells: more questions than answers (Q34716304)

4 August 2017

title

CD4+ CD25+ suppressor T cells: more questions than answers (English)

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CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

4 August 2017

main subject

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Gene Ontology release 2020-05-02

1

Ethan M Shevach

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4 August 2017

publication date

1 June 2002

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Nature Reviews Immunology

4 August 2017

language of work or name

English

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published in

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4 August 2017

volume

2

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4 August 2017

issue

6

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4 August 2017

page(s)

389-400

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publication type of scholarly work

4 August 2017

review article

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Do suppressor T cells exist?

cites work

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Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

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CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

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Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population

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Regulatory T cells: key controllers of immunologic self-tolerance

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Regulatory T cells in the control of immune pathology.

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Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

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Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

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Regulation of immune responses by TGF-beta

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

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Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

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CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells

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Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells

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Newly discovered role for Fas ligand in the cell-cycle arrest of CD4+ T cells

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

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Regulation through inhibitory receptors: Lessons from natural killer cells

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

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Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells

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Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes

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Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells

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Role of transforming growth factor-beta in tissue injury and repair

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T cell regulation: a special job or everyone's responsibility?

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Post-thymectomy autoimmunity: abnormal T-cell homeostasis

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Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

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Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

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Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

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Stat5a regulates T helper cell differentiation by several distinct mechanisms

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Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo

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Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: a role of CD40 in regulatory T cell development

31 March 2020

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms

31 March 2020

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Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance

31 March 2020

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The significance of immune suppression in normal self tolerance

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Peripheral autoantigen induces regulatory T cells that prevent autoimmunity

31 March 2020

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Persistence of physiological self antigen is required for the regulation of self tolerance

31 March 2020

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A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity

31 March 2020

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Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells

31 March 2020

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B cells and professional APCs recruit regulatory T cells via CCL4

31 March 2020

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Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis

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Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis

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Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment

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CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.

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Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

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Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells

31 March 2020

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A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood

31 March 2020

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Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance.

31 March 2020

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Mycophenolate mofetil impairs the maturation and function of murine dendritic cells

31 March 2020

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IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

31 March 2020

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Certified professionals: CD4(+)CD25(+) suppressor T cells

31 March 2020

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Anergic T cells inhibit the antigen-presenting function of dendritic cells

31 March 2020

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‘Anergic’ T cells Modulate the T-cell Activating Capacity of Antigen-presenting Cells

31 March 2020

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Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen

31 March 2020

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Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses

31 March 2020

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Stigma variations: observations on suppressor T cells and leprosy

31 March 2020

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The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

31 March 2020

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Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease

31 March 2020

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https://opencitations.net/index/api/v1/citations/10.1007/S00281-006-0043-2

31 March 2020

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7 October 2025

Identifiers

DOI

10.1038/NRI821

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