Small-molecular modulators of cancer-associated epigenetic mechanisms (Q34628002)

3 August 2017

Small-molecular modulators of cancer-associated epigenetic mechanisms (English)

1 reference

3 August 2017

Yukihiro Itoh

1

1 reference

PubMed ID

23511667

3 August 2017

Takayoshi Suzuki

series ordinal

2

1 reference

PubMed ID

23511667

3 August 2017

Naoki Miyata

series ordinal

3

1 reference

3 August 2017

1 May 2013

1 reference

3 August 2017

1 reference

3 August 2017

9

1 reference

3 August 2017

873-896

1 reference

3 August 2017

5

1 reference

Epigenetic modifications and human disease

3 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetic events in mammalian germ-cell development: reprogramming and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetic regulation in cell reprogramming revealed by genome-wide analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetic protein families: a new frontier for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetic modifications as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

New ways to use DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Targeting DNA methylation for epigenetic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylation in epigenetics: an attractive target for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

DNA methyltransferases as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Romidepsin: a novel histone deacetylase inhibitor for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone methylation: a dynamic mark in health, disease and inheritance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Chemical and biochemical approaches in the study of histone methylation and demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The new frontier in cancer research: deciphering cancer epigenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Transcriptional and epigenetic regulation of the p53 tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Readers of histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Chromatin modifications as therapeutic targets in MLL-rearranged leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Comparison of transformation efficiency of human active and inactive X-chromosomal DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The role of DNA methylation in setting up chromatin structure during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

DNA demethylation dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The discovery of 5-formylcytosine in embryonic stem cell DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

MethylScreen: DNA methylation density monitoring using quantitative PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Nucleosome-interacting proteins regulated by DNA and histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Linking DNA methylation and histone modification: patterns and paradigms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

DNA methylation, chromatin inheritance, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Molecular coupling of DNA methylation and histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cancer epigenomics: DNA methylomes and histone-modification maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cloning, expression and chromosome locations of the human DNMT3 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Dnmt3L and the establishment of maternal genomic imprints.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cellular differentiation, cytidine analogs and DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetics as a therapeutic target in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

2'-Deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine: a novel inhibitor of DNA methyltransferase that requires activation by human carboxylesterase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Anticancer drug discovery targeting DNA hypermethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Global DNA hypermethylation-associated cancer chemotherapy resistance and its reversion with the demethylating agent hydralazine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome. Preliminary results of a phase-II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Design, synthesis, inhibitory activity, and binding mode study of novel DNA methyltransferase 1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Physical and functional HAT/HDAC interplay regulates protein acetylation balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Linking genome structure and function through specific histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Acetylation of histones and transcription-related factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structure and acetyl-lysine recognition of the bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Human mitotic chromosome structure: what happened to the 30-nm fibre?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Acetylation and deacetylation of non-histone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylases and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Sirtuins and disease: the road ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Sirtuin chemical mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The biochemistry of sirtuins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Physiological roles of class I HDAC complex and histone demethylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The role of p53 deacetylation in p21Waf1 regulation by laminar flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylases specifically down-regulate p53-dependent gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Duration of nuclear NF-kappaB action regulated by reversible acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

HDAC family: What are the cancer relevant targets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

HDAC modulation and cell death in the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Non-hydroxamate histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone Deacetylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylase inhibitors (HDACIs). Structure--activity relationships: history and new QSAR perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Chemical phylogenetics of histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Mocetinostat (MGCD0103): a review of an isotype-specific histone deacetylase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Short-chain fatty acid inhibitors of histone deacetylases: promising anticancer therapeutics?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Isoform-selective histone deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Targeting epigenetic readers in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Multivalent engagement of chromatin modifications by linked binding modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

You bet-cha: a novel family of transcriptional regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

BET domain co-regulators in obesity, inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Small-molecule inhibition of BRDT for male contraception

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Translocations involving c-myc and c-myc function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A crack in histone lysine methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone modifications at human enhancers reflect global cell-type-specific gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

L3MBTL1 recognition of mono- and dimethylated histones

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

L3MBTL1, a histone-methylation-dependent chromatin lock

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Regulation of chromatin structure by site-specific histone H3 methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The emerging field of dynamic lysine methylation of non-histone proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone methyltransferases in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Protein methyltransferases as a target class for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Chemical probes for histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

H3K9 methyltransferase G9a and the related molecule GLP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

G9a and Glp methylate lysine 373 in the tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Repression of p53 activity by Smyd2-mediated methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural basis of substrate methylation and inhibition of SMYD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

hDOT1L links histone methylation to leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The Polycomb complex PRC2 and its mark in life

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Aberrations of EZH2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

EZH2 Y641 mutations in follicular lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

EZH2 couples pancreatic regeneration to neoplastic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A novel mammalian flavin-dependent histone demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Lysine demethylases inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

JmjC-domain-containing proteins and histone demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

p53 is regulated by the lysine demethylase LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Drosophila LSD1-CoREST demethylase complex regulates DPP/TGFβ signaling during wing development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

LSD1 inhibition: a therapeutic strategy in cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Breaking the LSD1/KDM1A addiction: therapeutic targeting of the epigenetic modifier in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

AOF1 is a histone H3K4 demethylase possessing demethylase activity-independent repression function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Role of androgen receptor and associated lysine-demethylase coregulators, LSD1 and JMJD2A, in localized and advanced human bladder cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A mechanism-based inactivator for histone demethylase LSD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Identification of cell-active lysine specific demethylase 1-selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone lysine demethylases: emerging roles in development, physiology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural insights into histone demethylation by JMJD2 family members.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The emerging role of histone lysine demethylases in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cooperative epigenetic modulation by cancer amplicon genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic Approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural basis for human PHF2 Jumonji domain interaction with metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Arginine methylation at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

High-resolution X-ray and NMR structures of the SMN Tudor domain: conformational variation in the binding site for symmetrically dimethylated arginine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

JMJD6 is a histone arginine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Methods for analyzing histone citrullination in chromatin structure and gene regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Methylation of histone H3 by coactivator-associated arginine methyltransferase 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Regulation of transcription by a protein methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The role of protein arginine-methyltransferase 1 in gliomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Protein arginine methylation in mammals: who, what, and why

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Small molecule regulators of protein arginine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A novel mechanism for inhibition of HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

A novel arginine methyltransferase inhibitor with cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Target-based approach to inhibitors of histone arginine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

An allosteric inhibitor of protein arginine methyltransferase 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Linking Heterochromatin Protein 1 (HP1) to cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

The cation-π interaction at protein-protein interaction interfaces: developing and learning from synthetic mimics of proteins that bind methylated lysines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Small-Molecule Ligands of Methyl-Lysine Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

21 January 2018

Global cancer statistics

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB25410K

[Isolation and configuration of Chaetocin]

21 January 2018

1 reference

COCI

https://opencitations.net/index/api/v1/citations/10.1002/HLCA.19700530521

9 March 2024

Identifiers

DOI

10.1039/C3MB25410K

1 reference

3 August 2017

1 reference

PubMed ID

23511667