An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension (Q34557130)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16157792%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

title

An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension (English)

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6 January 2020

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6

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6 January 2020

author name string

John D Imig

1

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6 January 2020

Xueying Zhao

2

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6 January 2020

Constantine Z Zaharis

3

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6 January 2020

Jeffrey J Olearczyk

4

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6 January 2020

David M Pollock

5

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6 January 2020

In-Hae Kim

7

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6 January 2020

Takaho Watanabe

8

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6 January 2020

Bruce D Hammock

9

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6 January 2020

language of work or name

English

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publication date

12 September 2005

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6 January 2020

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6 January 2020

volume

46

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6 January 2020

page(s)

975-981

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6 January 2020

issue

4

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Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.

6 January 2020

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1 reference

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7 July 2018

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Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway

7 July 2018

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Immunosuppressive treatment protects against angiotensin II-induced renal damage

7 July 2018

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Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II

7 July 2018

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Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension

7 July 2018

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P-450 metabolites of arachidonic acid in the control of cardiovascular function

7 July 2018

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Eicosanoid regulation of the renal vasculature

7 July 2018

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The epidemic of cardiovascular disease in end-stage renal disease

7 July 2018

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The role of the kidney in hypertension

7 July 2018

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Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet

7 July 2018

1 reference

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Effects of long-term increases in plasma ANP on angiotensin II-induced hypertension

7 July 2018

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Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension

7 July 2018

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Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat.

27 October 2018

1 reference

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TP receptors regulate renal hemodynamics during angiotensin II slow pressor response

27 October 2018

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Chronic cyclooxygenase-2 inhibition does not alter blood pressure and kidney function in renovascular hypertensive rats

27 October 2018

1 reference

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Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.

27 October 2018

1 reference

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Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility

27 October 2018

1 reference

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Role of prostaglandin E receptor EP1 subtype in the development of renal injury in genetically hypertensive rats

27 October 2018

1 reference

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In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea.

27 October 2018

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Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension.

27 October 2018

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Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene (TGR[mREN2]27).

27 October 2018

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Role of macula densa cyclooxygenase-2 in renovascular hypertension

27 October 2018

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The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS.

27 October 2018

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Structural refinement of inhibitors of urea-based soluble epoxide hydrolases

27 October 2018

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Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid

27 October 2018

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Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.

27 October 2018

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Cytochrome P-450 arachidonate metabolite inhibition improves renal function in Lyon hypertensive rats

27 October 2018

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27 October 2018

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27 October 2018

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Enhanced renal PGE2 in hypertensives with increased red cell Na(+)-Li+ countertransport

27 October 2018

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12 December 2020

Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension

1 reference

12 December 2020

Salt-sensitive hypertension after exposure to angiotensin is associated with inability to upregulate renal epoxygenases

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12 December 2020

Renal endothelin in chronic angiotensin II hypertension

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12 December 2020

Expression of prostaglandin H2-mediated mechanism of vascular contraction in hypertensive rats. Relation to lipoxygenase and prostacyclin synthase activities

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12 December 2020

Coordinate expression of cyclooxygenase-2 and renin in the rat kidney in renovascular hypertension

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12 December 2020

Interactions of cAMP-mediated vasodilators with angiotensin II in rat kidney during hypertension

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12 December 2020

Salt-sensitive hypertension develops after short-term exposure to Angiotensin II

1 reference

12 December 2020

10.1161/01.HYP.0000176237.74820.75

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16157792%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16157792%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference