Interleukin 2 signaling is required for CD4(+) regulatory T cell function (Q34527240)

2 August 2017

title

Interleukin 2 signaling is required for CD4(+) regulatory T cell function (English)

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2 August 2017

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Gláucia C Furtado

1

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2 August 2017

Maria A Curotto de Lafaille

series ordinal

2

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2 August 2017

Nino Kutchukhidze

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3

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2 August 2017

Juan J Lafaille

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4

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2 August 2017

publication date

1 September 2002

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Journal of Experimental Medicine

2 August 2017

language of work or name

English

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published in

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2 August 2017

volume

196

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2 August 2017

issue

6

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2 August 2017

page(s)

851-857

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Regulatory T cells in spontaneous autoimmune encephalomyelitis

2 August 2017

cites work

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Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes✪

7 July 2018

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Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

7 July 2018

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Regulatory T cells: key controllers of immunologic self-tolerance

7 July 2018

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7 July 2018

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Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo

7 July 2018

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High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993

7 July 2018

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

7 July 2018

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Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis

7 July 2018

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CD4(+) T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice

7 July 2018

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CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

7 July 2018

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Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

7 July 2018

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Natural history and therapy of metastatic renal cell carcinoma: the role of interleukin-2.

7 July 2018

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

7 July 2018

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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

7 July 2018

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Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

7 July 2018

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Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells

7 July 2018

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Interleukin 2 regulates its own receptors

7 July 2018

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Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

7 July 2018

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

7 July 2018

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Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice

21 January 2018

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Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

21 January 2018

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Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state

21 January 2018

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Phase II trial of systemic recombinant interleukin-2 in the treatment of refractory nasopharyngeal carcinoma.

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Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

21 January 2018

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12 December 2020

Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis

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12 December 2020

CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10

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12 December 2020

Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms

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12 December 2020

Regulation of interleukin 2 (IL2) receptor expression: IL2 as an inducing signal for the expression of its own receptor on a murine T helper cell line

1 reference

12 December 2020

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1 reference

12 December 2020

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

12 December 2020

Induction of sensitivity to activation-induced death in primary CD4+ cells: a role for interleukin-2 in the negative regulation of responses by mature CD4+ T cells

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12 December 2020

Interleukin-2 is indispensable for development of immunological self-tolerance

1 reference

12 December 2020

Neo-adjuvant chemo-(immuno-)therapy of advanced squamous-cell head and neck carcinoma: a multicenter, phase III, randomized study comparing cisplatin + 5-fluorouracil (5-FU) with cisplatin + 5-FU + recombinant interleukin 2

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12 December 2020

CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis

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12 December 2020

https://opencitations.net/index/api/v1/citations/10.1007/S00281-006-0043-2

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7 October 2025

Identifiers

DOI

10.1084/JEM.20020190

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2 August 2017

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2 August 2017

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