Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system (Q34497857)

2 August 2017

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system (English)

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2 August 2017

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Dudley W Lamming

9

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author name string

Sebastian I Arriola Apelo

1

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2 August 2017

Joshua C Neuman

2

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2 August 2017

Emma L Baar

3

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2 August 2017

Faizan A Syed

4

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2 August 2017

Nicole E Cummings

5

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2 August 2017

Harpreet K Brar

6

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2 August 2017

Cassidy P Pumper

7

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2 August 2017

Michelle E Kimple

8

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2 August 2017

13 October 2015

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2 August 2017

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2 August 2017

15

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2 August 2017

28-38

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2 August 2017

1

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describes a project that uses

2 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4717280/fullTextXML

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inferred from PubMed Central ID database lookup

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4717280/fullTextXML

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inferred from PubMed Central ID database lookup

cites work

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mTOR inhibition improves immune function in the elderly

7 July 2018

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Rapamycin-induced metabolic defects are reversible in both lean and obese mice

7 July 2018

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Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

7 July 2018

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Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections

7 July 2018

1 reference

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Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide

7 July 2018

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The small GTPase Rheb is required for spermatogenesis but not oogenesis

7 July 2018

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Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice

7 July 2018

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Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

7 July 2018

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eRapa restores a normal life span in a FAP mouse model.

7 July 2018

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Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

7 July 2018

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Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

7 July 2018

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Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.

7 July 2018

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Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

7 July 2018

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

7 July 2018

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Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion

7 July 2018

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mTOR is a key modulator of ageing and age-related disease

7 July 2018

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Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

7 July 2018

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Rapamycin slows aging in mice

7 July 2018

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

7 July 2018

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7 July 2018

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Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

7 July 2018

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Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques

7 July 2018

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Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size

7 July 2018

1 reference

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Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

7 July 2018

1 reference

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Rapamycin extends maximal lifespan in cancer-prone mice

7 July 2018

1 reference

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Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

7 July 2018

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The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents

7 July 2018

1 reference

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Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Specific control of immunity by regulatory CD8 T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

The evolving experience using everolimus in clinical transplantation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Correct homeostasis model assessment (HOMA) evaluation uses the computer program

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

The TSC-mTOR pathway regulates macrophage polarization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Surrogate measures of insulin resistance: of rats, mice, and men.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

Cutaneous adverse events in renal transplant recipients receiving sirolimus-based therapy

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4717280

27 October 2018

Identifiers

DOI

10.1111/ACEL.12405

1 reference

2 August 2017

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2 August 2017

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