Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses (Q34468309)

2 August 2017

title

Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses (English)

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2 August 2017

3

J M White

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2 August 2017

S J Rodig

1

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2 August 2017

M A Meraz

2

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2 August 2017

P A Lampe

4

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2 August 2017

J K Riley

5

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C D Arthur

6

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K L King

7

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K C Sheehan

8

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L Yin

9

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D Pennica

10

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E M Johnson

11

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R D Schreiber

12

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2 August 2017

publication date

1 May 1998

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2 August 2017

language of work or name

0 references

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2 August 2017

volume

93

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2 August 2017

issue

3

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2 August 2017

page(s)

373-383

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Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

2 August 2017

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

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Tissue-specific targeting of cytokine unresponsiveness in transgenic mice

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Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

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Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

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Functional regions of the mouse interleukin-10 receptor cytoplasmic domain

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Immune response in mice that lack the interferon-gamma receptor

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Signaling through the hematopoietic cytokine receptors.

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Cardiac fibroblasts produce leukemia inhibitory factor and endothelin, which combine to induce cardiac myocyte hypertrophy in vitro

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Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5.

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Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development

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Essential function of LIF receptor in motor neurons

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Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

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The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

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Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation

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Defective lymphoid development in mice lacking Jak3

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Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?

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Jak2 is essential for signaling through a variety of cytokine receptors

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7 January 2021

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.

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7 January 2021

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

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7 January 2021

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

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7 January 2021

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

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7 January 2021

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

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A protein tyrosine kinase in the interferon alpha/beta signaling pathway

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7 January 2021

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

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7 January 2021

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway

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7 January 2021

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

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7 January 2021

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Identifiers

DOI

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2 August 2017

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