The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice. (Q34403310)

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3 February 2020

title

The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice (English)

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3 February 2020

main subject

mesenchymal stem cell

1 reference

1

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3 February 2020

Adam P. Croft

4

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Caroline Ospelt

9

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3 February 2020

Clare M Isacke

11

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3 February 2020

Michael J. Rogers

13

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3 February 2020

Christopher D Buckley

14

object named as

Christopher D Buckley

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author name string

Eman Azzam

2

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3 February 2020

Stuart Smith

3

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3 February 2020

Callum Poyser

5

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3 February 2020

Jeremy S Duffield

6

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3 February 2020

David L Huso

7

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Steffen Gay

8

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Mark S Cooper

10

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Simon R Goodyear

12

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publication date

1 October 2012

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3 February 2020

published in

Arthritis and Rheumatism

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3 February 2020

volume

64

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issue

10

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3 February 2020

page(s)

3334-3343

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describes a project that uses

3 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4209224/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

CD248+ stromal cells are associated with progressive chronic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures

6 July 2018

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Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.

6 July 2018

1 reference

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Endosialin/TEM-1/CD248 regulates pericyte proliferation through PDGF receptor signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling

6 July 2018

1 reference

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Endosialin/TEM 1/CD248 is a pericyte marker of embryonic and tumor neovascularization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

Interaction of endosialin/TEM1 with extracellular matrix proteins mediates cell adhesion and migration

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors

6 July 2018

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Stem cell niche: structure and function

6 July 2018

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Isolation and characterization of a scFv antibody specific for tumor endothelial marker 1 (TEM1), a new reagent for targeted tumor therapy

6 July 2018

1 reference

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Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

A gene atlas of the mouse and human protein-encoding transcriptomes

6 July 2018

1 reference

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Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: induction of cyclin A and enhanced CDK2 activity

6 July 2018

1 reference

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The mature osteoblast phenotype is characterized by extensive plasticity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

Pro-inflammatory cytokines downregulate platelet derived growth factor-alpha receptor gene expression in human osteoblastic cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209224

Endosialin is expressed on stromal fibroblasts and CNS pericytes in mouse embryos and is downregulated during development.

6 July 2018

1 reference

CD248 and its cytoplasmic domain: a therapeutic target for arthritis

21 January 2018

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Human mesenchymal stem cells from bone marrow express tumor endothelial and stromal markers.

21 January 2018

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DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells

21 January 2018

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Growth of C57BL/6 mice and the material and mechanical properties of cortical bone from the tibia.

21 January 2018

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Genetic variability in adult bone density among inbred strains of mice.

21 January 2018

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Platelet-released supernatants increase migration and proliferation, and decrease osteogenic differentiation of bone marrow-derived mesenchymal progenitor cells under in vitro conditions.

21 January 2018

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Inhibition of platelet-derived growth factor receptorbeta by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitro.

21 January 2018

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PDGF receptor beta is a potent regulator of mesenchymal stromal cell function

21 January 2018

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Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice

21 January 2018

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Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22674221

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Imatinib Promotes Osteoblast Differentiation by Inhibiting PDGFR Signaling and Inhibits Osteoclastogenesis by Both Direct and Stromal Cell-Dependent Mechanisms

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22674221

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/ART.34556

1 reference

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3 February 2020

1 reference

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3 February 2020

PubMed publication ID

22674221

1 reference

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