Assembly of the phagocyte NADPH oxidase (Q34338562)

1 August 2017

title

Assembly of the phagocyte NADPH oxidase (English)

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1 August 2017

William M Nauseef

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1 August 2017

publication date

4 August 2004

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Histochemistry and Cell Biology

1 August 2017

language of work or name

English

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published in

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1 August 2017

volume

122

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1 August 2017

issue

4

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1 August 2017

page(s)

277-291

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publication type of scholarly work

1 August 2017

review article

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Changing the conformation state of cytochrome b558 initiates NADPH oxidase activation: MRP8/MRP14 regulation

cites work

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12 December 2020

Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase

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12 December 2020

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

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12 December 2020

Properties of phagocyte NADPH oxidase p47-phox mutants with unmasked SH3 (Src homology 3) domains: full reconstitution of oxidase activity in a semi-recombinant cell-free system lacking arachidonic acid

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12 December 2020

Association between calnexin and a secretion-incompetent variant of human alpha 1-antitrypsin.

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12 December 2020

The cytosolic components of the respiratory burst oxidase exist as a M(r) approximately 240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free system

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12 December 2020

Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation

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12 December 2020

Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox

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12 December 2020

Neutrophil nicotinamide adenine dinucleotide phosphate oxidase assembly. Translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome b558.

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12 December 2020

Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox).

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12 December 2020

Transient association of the nicotinamide adenine dinucleotide phosphate oxidase subunits p47phox and p67phox with phagosomes in neutrophils from patients with X-linked chronic granulomatous disease

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12 December 2020

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

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12 December 2020

Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail.

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12 December 2020

Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display libraries

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12 December 2020

Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

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12 December 2020

P67-phox-mediated NADPH oxidase assembly: imaging of cytochrome b558 liposomes by atomic force microscopy

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12 December 2020

Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox

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12 December 2020

Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex

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12 December 2020

Novel cytochrome b system in phagocytic vacuoles of human granulocytes

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12 December 2020

Rho GTPases in cell biology

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12 December 2020

Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47(phox). Triple replacement of serines 303, 304, and 328 with aspartates disrupts the SH3 domain-mediated intramolecular interaction in p47(phox), thereby acti

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12 December 2020

Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (first update).

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12 December 2020

Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.

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12 December 2020

Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox

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12 December 2020

A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase

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12 December 2020

The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes

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12 December 2020

Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation

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12 December 2020

Functional analysis of NADPH oxidase in granulocytic cells expressing a delta488-497 gp91(phox) deletion mutant.

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12 December 2020

The PX domain as a novel phosphoinositide- binding module

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12 December 2020

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?

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12 December 2020

Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes

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12 December 2020

Cloning of a 67-kD neutrophil oxidase factor with similarity to a noncatalytic region of p60c-src

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12 December 2020

Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558.

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12 December 2020

Role of myeloperoxidase in the respiratory burst of human neutrophils

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12 December 2020

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

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12 December 2020

Surfactant protein a promotes attachment of Mycobacterium tuberculosis to alveolar macrophages during infection with human immunodeficiency virus

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12 December 2020

A fatal granulomatous disease of childhood; the clinical, pathological, and laboratory features of a new syndrome.

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12 December 2020

Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox

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12 December 2020

Mapping of functional domains in p47(phox) involved in the activation of NADPH oxidase by "peptide walking".

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12 December 2020

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components

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12 December 2020

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

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12 December 2020

The major phosphorylation site of the NADPH oxidase component p67phox is Thr233.

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12 December 2020

Synthetic peptides corresponding to various hydrophilic regions of the large subunit of cytochrome b558 inhibit superoxide generation in a cell-free system from neutrophils

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12 December 2020

The neutrophil NADPH oxidase

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12 December 2020

Continuous Translocation of Rac2 and the NADPH Oxidase Component p67 during Phagocytosis

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12 December 2020

Evidence for a readily dissociable complex of p47phox and p67phox in cytosol of unstimulated human neutrophils.

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12 December 2020

Phosphorylation of p67 phox in the neutrophil occurs in the cytosol and is independent of p47 phox

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12 December 2020

In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood

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12 December 2020

Restitution of superoxide generation in autosomal cytochrome-negative chronic granulomatous disease (A22(0) CGD)-derived B lymphocyte cell lines by transfection with p22phax cDNA.

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12 December 2020

Induction of apoptosis by the Bcl-2 homologue Bak

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12 December 2020

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

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12 December 2020

Toward an understanding of biomaterial infections: a complex interplay between the host and bacteria

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12 December 2020

A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox

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12 December 2020

The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.

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12 December 2020

Identification of intracellular sites of superoxide production in stimulated neutrophils

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12 December 2020

Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65

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12 December 2020

Modulation of p47 PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase

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12 December 2020

The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils

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12 December 2020

Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

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12 December 2020

Functional epitope on human neutrophil flavocytochrome b558.

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12 December 2020

A Fusion Protein between Rac and p67phox (1−210) Reconstitutes NADPH Oxidase with Higher Activity and Stability than the Individual Components

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12 December 2020

Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b

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12 December 2020

Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558 II.

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12 December 2020

Disturbed interaction of p21-rac with mutated p67-phox causes chronic granulomatous disease

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12 December 2020

Remarkable stabilization of neutrophil NADPH oxidase using RacQ61L and a p67phox-p47phox fusion protein

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12 December 2020

Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras

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12 December 2020

Clinical features of a human Rac2 mutation: a complex neutrophil dysfunction disease

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12 December 2020

Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304.

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12 December 2020

Phosphorylation of the respiratory burst oxidase subunit p67(phox) during human neutrophil activation. Regulation by protein kinase C-dependent and independent pathways

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12 December 2020

Structure of the TPR domain of p67phox in complex with Rac.GTP

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12 December 2020

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system

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12 December 2020

Mutagenesis of an arginine- and lysine-rich domain in the gp91(phox) subunit of the phagocyte NADPH-oxidase flavocytochrome b558.

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12 December 2020

p21rac does not participate in the early interaction between p47-phox and cytochrome b558 that leads to phagocyte NADPH oxidase activation in vitro

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12 December 2020

Specificity of p47phox SH3 domain interactions in NADPH oxidase assembly and activation

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12 December 2020

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

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12 December 2020

Role of CD47 as a marker of self on red blood cells

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12 December 2020

Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

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12 December 2020

The active N-terminal region of p67phox. Structure at 1.8 A resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease

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12 December 2020

Activation of the Superoxide-Generating NADPH Oxidase by Chimeric Proteins Consisting of Segments of the Cytosolic Component p67phoxand the Small GTPase Rac1

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12 December 2020

Two cytosolic neutrophil oxidase components absent in autosomal chronic granulomatous disease

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12 December 2020

Characterization of the Effector-specifying Domain of Rac Involved in NADPH Oxidase Activation

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12 December 2020

Phosphorylation of the NADPH Oxidase Component p67PHOX by ERK2 and P38MAPK: Selectivity of Phosphorylated Sites and Existence of an Intramolecular Regulatory Domain in the Tetratricopeptide-Rich Region

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12 December 2020

Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes

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12 December 2020

Chronic granulomatous disease of childhood: a saga of discovery and understanding.

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12 December 2020

Nucleoside triphosphate requirements for superoxide generation and phosphorylation in a cell-free system from human neutrophils. Sodium dodecyl sulfate and diacylglycerol activate independently of protein kinase C

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12 December 2020

Multiple SH3 domain interactions regulate NADPH oxidase assembly in whole cells

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12 December 2020

Translocation of p21rac2 from cytosol to plasma membrane is neither necessary nor sufficient for neutrophil NADPH oxidase activity

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12 December 2020

Comparative aspects of oxidative metabolism of neutrophils from human blood and guinea pig peritonea: Magnitude of the respiratory burst, dependence upon stimulating agents, and localization of the oxidases

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12 December 2020

Current molecular models for NADPH oxidase regulation by Rac GTPase

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12 December 2020

Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains

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12 December 2020

Solution structure of the PX domain, a target of the SH3 domain

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12 December 2020

Activation of a NADPH oxidase from horse polymorphonuclear leukocytes in a cell-free system

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12 December 2020

Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunits

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12 December 2020

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

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12 December 2020

SH3 domain-mediated interactions involving the phox components of the NADPH oxidase

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12 December 2020

Fused p47phox and p67phox truncations efficiently reconstitute NADPH oxidase with higher activity and stability than the individual components

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12 December 2020

Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins

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12 December 2020

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

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12 December 2020

Interactions between cytosolic components of the NADPH oxidase: p40phox interacts with both p67phox and p47phox

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12 December 2020

Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils

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12 December 2020

Membrane association of Rac is required for high activity of the respiratory burst oxidase

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12 December 2020

The mechanism of activation of NADPH oxidase in the cell-free system: the activation process is primarily catalytic and not through the formation of a stoichiometric complex

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12 December 2020

Analysis of Activation-induced Conformational Changes in p47 Using Tryptophan Fluorescence Spectroscopy

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12 December 2020

Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox).

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12 December 2020

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

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12 December 2020

p40(phox) Participates in the activation of NADPH oxidase by increasing the affinity of p47(phox) for flavocytochrome b(558).

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12 December 2020

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase

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12 December 2020

A new role of Pro-73 of p47phox in the activation of neutrophil NADPH oxidase

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12 December 2020

The p47phox PX domain: two heads are better than one!

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12 December 2020

Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein

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12 December 2020

The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex

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12 December 2020

NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system

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12 December 2020

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

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12 December 2020

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase

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12 December 2020

Chronic granulomatous disease. Report on a national registry of 368 patients

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12 December 2020

Purification of the 260 kDa cytosolic complex involved in the superoxide production of guinea pig neutrophils

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12 December 2020

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

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12 December 2020

Subcellular localization of H2O2 production in human neutrophils stimulated with particles and an effect of cytochalasin-B on the cells

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12 December 2020

Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes

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12 December 2020

A domain of p47phox that interacts with human neutrophil flavocytochrome b558.

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12 December 2020

Mechanisms of phagocytosis in macrophages

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12 December 2020

The Small GTP-Binding Protein rac Is Not Recruited to the Plasma Membrane upon NADPH Oxidase Activation in Human Neutrophils

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12 December 2020

The NADPH-dependent oxidase of phagocytes.

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12 December 2020

Regulation of NADPH oxidase activity by Rac GTPase activating protein(s).

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12 December 2020

Functional domain in an arginine-rich carboxyl-terminal region of p47phox

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12 December 2020

Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

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12 December 2020

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

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12 December 2020

A structural model for the nucleotide binding domains of the flavocytochrome b-245 beta-chain

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12 December 2020

Mutational Analysis of Novel Effector Domains in Rac1 Involved in the Activation of Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase

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12 December 2020

Leukocyte oxidase: defective activity in chronic granulomatous disease

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12 December 2020

p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain

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12 December 2020

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

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12 December 2020

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox

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12 December 2020

Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane.

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12 December 2020

Quantitative nitroblue tetrazolium test in chronic granulomatous disease

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12 December 2020

Immunodeficiency diseases caused by defects in phagocytes

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12 December 2020

Dissociation of Rac translocation from p47phox/p67phox movements in human neutrophils by tyrosine kinase inhibitors.

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12 December 2020

Assembly and activation of the neutrophil NADPH oxidase in granule membranes

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12 December 2020

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase

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12 December 2020

Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p

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12 December 2020

Activation of the respiratory burst enzyme from human neutrophils in a cell-free system. Evidence for a soluble cofactor

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12 December 2020

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

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12 December 2020

Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation

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12 December 2020

Chronic granulomatous disease.

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12 December 2020

Roles for Proline-Rich Regions of p47phoxand p67phoxin the Phagocyte NADPH Oxidase Activationin Vitro

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12 December 2020

Oxygen and the inflammatory cell

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12 December 2020

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

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12 December 2020

Antibody imprint of a membrane protein surface. Phagocyte flavocytochrome b

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12 December 2020

Termination of the Respiratory Burst in Human Neutrophils

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12 December 2020

Molecular basis of phosphorylation-induced activation of the NADPH oxidase

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12 December 2020

Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages

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12 December 2020

NADPH oxidase: an update

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12 December 2020

Neutrophil NADPH oxidase does not assemble on macropinocytic vacuole membranes

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12 December 2020

Subcellular localization of hydrogen peroxide production in human polymorphonuclear leukocytes stimulated with lectins, phorbol myristate acetate, and digitonin: an electron microscopic study using CeCl3

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12 December 2020

Four novel mutations in the gene encoding gp91-phox of human NADPH oxidase: consequences for oxidase assembly

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12 December 2020

Two forms of autosomal chronic granulomatous disease lack distinct neutrophil cytosol factors.

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12 December 2020

Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients

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12 December 2020

The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558)

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12 December 2020

NADPH oxidase activation and assembly during phagocytosis

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12 December 2020

Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase

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12 December 2020

Anionic amphiphile-independent activation of the phagocyte NADPH oxidase in a cell-free system by p47phox and p67phox, both in C terminally truncated forms. Implication for regulatory Src homology 3 domain-mediated interactions.

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12 December 2020

The PC motif: a novel and evolutionarily conserved sequence involved in interaction between p40phox and p67phox, SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidase

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12 December 2020

The black cat/white cat principle of signal integration in bacterial promoters

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12 December 2020

Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis

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12 December 2020

Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase

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12 December 2020

Genomic structure, chromosomal localization, start of transcription, and tissue expression of the human p40-phox, a new component of the nicotinamide adenine dinucleotide phosphate-oxidase complex

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12 December 2020

Topological mapping of neutrophil cytochrome b epitopes with phage-display libraries

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12 December 2020

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

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12 December 2020

Chronic familial granulomatosis. Report of five cases and review of the literature

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12 December 2020

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

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12 December 2020

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

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12 December 2020

Fatal granulomatous disease of childhood. An inborn abnormality of phagocytic function

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12 December 2020

10.1007/S00418-004-0679-8

Identifiers

DOI

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1 August 2017

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