Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases (Q34122676)

31 July 2017

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title

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases (English)

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31 July 2017

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ChEBI release 2020-05-28

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3

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31 July 2017

Daniel I Perez

1

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Carmen Gil

object named as

Carmen Gil

series ordinal

2

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publication date

23 June 2010

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Medicinal Research Reviews

31 July 2017

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31 July 2017

31

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31 July 2017

924-954

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31 July 2017

6

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Protein kinases--the major drug targets of the twenty-first century?

31 July 2017

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Protein kinase inhibitors: contributions from structure to clinical compounds

21 January 2018

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Targeting cancer with small molecule kinase inhibitors

21 January 2018

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ATP-noncompetitive inhibitors of CDK-cyclin complexes.

21 January 2018

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Tumorigenesis and neurodegeneration: two sides of the same coin?

21 January 2018

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JNK signalling: a possible target to prevent neurodegeneration.

21 January 2018

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Rho kinase, a promising drug target for neurological disorders

21 January 2018

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MAPKs: new targets for neurodegeneration

21 January 2018

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Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders

21 January 2018

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The protein kinase complement of the human genome

21 January 2018

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Casein kinase I transduces Wnt signals.

21 January 2018

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Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes

21 January 2018

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The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

21 January 2018

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Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.

21 January 2018

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Autophosphorylation of carboxy-terminal residues inhibits the activity of protein kinase CK1alpha

21 January 2018

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Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta

21 January 2018

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Identification of inhibitory autophosphorylation sites in casein kinase I epsilon

21 January 2018

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Physiological role for casein kinase 1 in glutamatergic synaptic transmission.

21 January 2018

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The effects of connexin phosphorylation on gap junctional communication

21 January 2018

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The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development

21 January 2018

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Casein kinase I-like protein kinases encoded by YCK1 and YCK2 are required for yeast morphogenesis

21 January 2018

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CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

21 January 2018

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Casein kinase I: another cog in the circadian clockworks

21 January 2018

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Circadian rhythms in the CNS and peripheral clock disorders: human sleep disorders and clock genes

21 January 2018

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Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

21 January 2018

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A new molecular link between the fibrillar and granulovacuolar lesions of Alzheimer's disease

21 January 2018

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Casein kinase-1 isoforms differentially associate with neurofibrillary and granulovacuolar degeneration lesions.

21 January 2018

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Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain.

21 January 2018

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Amyloid beta-protein stimulates casein kinase I and casein kinase II activities.

21 January 2018

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Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases.

21 January 2018

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Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules

21 January 2018

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Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

21 January 2018

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Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I

21 January 2018

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Tau therapeutic strategies for the treatment of Alzheimer's disease

21 January 2018

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

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Identification of casein kinase-1 phosphorylation sites on TDP-43.

21 January 2018

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21 January 2018

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Neurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes: a review

21 January 2018

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Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

21 January 2018

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RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

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Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.

21 January 2018

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Dopamine covalently modifies and functionally inactivates parkin

21 January 2018

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S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

21 January 2018

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Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

21 January 2018

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Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening

21 January 2018

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Crystal structure of a conformation-selective casein kinase-1 inhibitor

21 January 2018

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p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

21 January 2018

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Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo.

21 January 2018

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Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines

21 January 2018

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

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An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions

21 January 2018

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Inhibition of casein kinase I epsilon/delta produces phase shifts in the circadian rhythms of Cynomolgus monkeys.

21 January 2018

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Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period

21 January 2018

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Modeling of a human circadian mutation yields insights into clock regulation by PER2

21 January 2018

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A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.

21 January 2018

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Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

21 January 2018

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D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.

21 January 2018

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The selectivity of protein kinase inhibitors: a further update

21 January 2018

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Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.

21 January 2018

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Polyhalogenobenzimidazoles: synthesis and their inhibitory activity against casein kinases

21 January 2018

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Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

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Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

21 January 2018

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Cyclin-dependent kinase inhibitor Roscovitine induces apoptosis in chronic lymphocytic leukemia cells.

21 January 2018

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Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

21 January 2018

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Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

21 January 2018

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Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest

21 January 2018

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Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.

21 January 2018

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Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)

21 January 2018

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Inhibition of protein kinase CK2 by condensed polyphenolic derivatives. An in vitro and in vivo study

21 January 2018

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Synthesis and kinase inhibitory activity of novel substituted indigoids.

21 January 2018

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3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.

21 January 2018

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Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum.

21 January 2018

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Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives

21 January 2018

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Characterization of (-)-matairesinol as a potent inhibitor of casein kinase I in vitro

21 January 2018

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Anticancer alkaloid lamellarins inhibit protein kinases

21 January 2018

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Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

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Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

21 January 2018

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The regulatory beta subunit of protein kinase CK2 mediates formation of tetrameric CK2 complexes

21 January 2018

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Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights.

21 January 2018

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One-thousand-and-one substrates of protein kinase CK2?

21 January 2018

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Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit.

21 January 2018

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Casein kinase 2 as a potentially important enzyme in the nervous system

21 January 2018

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Protein kinase CK2 in health and disease: CK2: a key player in cancer biology

21 January 2018

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Different expression patterns of CK2 subunits in the brains of experimental animals and patients with transmissible spongiform encephalopathies.

21 January 2018

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CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content

21 January 2018

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Protein kinase CK2: a newcomer in the 'druggable kinome'.

21 January 2018

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Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.

21 January 2018

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Protein kinase CK2 in human diseases.

21 January 2018

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Aberrant casein kinase II in Alzheimer's disease

21 January 2018

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Casein kinase II is associated with neurofibrillary tangles but is not an intrinsic component of paired helical filaments

21 January 2018

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Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy

21 January 2018

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Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

21 January 2018

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Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

21 January 2018

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Phosphorylation of apolipoprotein-E at an atypical protein kinase CK2 PSD/E site in vitro.

21 January 2018

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Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

21 January 2018

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Glycogen synthase kinase 3 phosphorylation of different residues in the presence of different factors: analysis on tau protein.

21 January 2018

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Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

21 January 2018

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Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

21 January 2018

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Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation

21 January 2018

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Hemoglobin neurotoxicity is attenuated by inhibitors of the protein kinase CK2 independent of heme oxygenase activity

21 January 2018

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Neurotrophin-induced activation of casein kinase 2 in rat hippocampal slices.

21 January 2018

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Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress

21 January 2018

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Protein kinase CK2 modulates synaptic plasticity by modification of synaptic NMDA receptors in the hippocampus

21 January 2018

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New protein kinase CK2 inhibitors: jumping out of the catalytic box.

21 January 2018

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Expanding the chemical diversity of CK2 inhibitors.

21 January 2018

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A structural insight into CK2 inhibition

21 January 2018

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Features and potentials of ATP-site directed CK2 inhibitors

21 January 2018

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Development and exploitation of CK2 inhibitors

21 January 2018

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Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources.

21 January 2018

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Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.

21 January 2018

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Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

21 January 2018

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Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole

21 January 2018

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Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole

21 January 2018

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2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

21 January 2018

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The selectivity of inhibitors of protein kinase CK2: an update

21 January 2018

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Tetraiodobenzimidazoles are potent inhibitors of protein kinase CK2.

21 January 2018

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The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2

21 January 2018

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Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight

21 January 2018

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Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

21 January 2018

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Toward the rational design of protein kinase casein kinase-2 inhibitors

21 January 2018

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Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking

21 January 2018

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Antitumor effect of a novel proapoptotic peptide that impairs the phosphorylation by the protein kinase 2 (casein kinase 2).

21 January 2018

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Systemic administration of a peptide that impairs the protein kinase (CK2) phosphorylation reduces solid tumor growth in mice.

21 January 2018

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CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo

21 January 2018

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Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2.

21 January 2018

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p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.

21 January 2018

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Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

21 January 2018

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Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction

21 January 2018

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Identification of chemical inhibitors of protein-kinase CK2 subunit interaction.

21 January 2018

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Targeting protein kinases in central nervous system disorders

21 January 2018

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Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.

21 January 2018

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The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules

21 January 2018

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The blood-brain barrier: bottleneck in brain drug development

21 January 2018

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Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart

21 January 2018

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Mass Spectrometry Analysis of a Protein Kinase CK2β Subunit Interactome Isolated from Mouse Brain by Affinity Chromatography

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.20207

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31 July 2017

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PubMed ID

20577972