Chromosome segregation and cancer: cutting through the mystery (Q34119639)

31 July 2017

title

Chromosome segregation and cancer: cutting through the mystery (English)

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31 July 2017

Jallepalli PV

1

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31 July 2017

Lengauer C

series ordinal

2

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31 July 2017

publication date

1 November 2001

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31 July 2017

language of work or name

English

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published in

Nature Reviews Cancer

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31 July 2017

volume

1

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31 July 2017

issue

2

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31 July 2017

page(s)

109-117

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publication type of scholarly work

31 July 2017

review article

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Walther Flemming: pioneer of mitosis research

cites work

1 reference

7 January 2021

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

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7 January 2021

Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis

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7 January 2021

Chromosomal passengers and the (aurora) ABCs of mitosis

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7 January 2021

Polo-like kinases: positive regulators of cell division from start to finish.

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7 January 2021

Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cells

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7 January 2021

Chromosomal instability and cytoskeletal defects in oral cancer cells

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7 January 2021

p53 mutations in human cancers

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7 January 2021

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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7 January 2021

Ataxia telangiectasia gene mutations in leukaemia and lymphoma

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7 January 2021

Mutations of mitotic checkpoint genes in human cancers

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7 January 2021

Abnormal centrosome amplification in the absence of p53.

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7 January 2021

Analysis of human transcriptomes

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7 January 2021

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

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7 January 2021

Expression of pituitary-tumour transforming gene in colorectal tumours

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7 January 2021

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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7 January 2021

Nonrandom chromosomal abnormalities in hematologic disorders of man

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7 January 2021

The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene

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7 January 2021

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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7 January 2021

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

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7 January 2021

A genetic model for colorectal tumorigenesis

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7 January 2021

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors

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7 January 2021

Karyotyping human chromosomes by combinatorial multi-fluor FISH.

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7 January 2021

Multicolor Spectral Karyotyping of Human Chromosomes

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7 January 2021

HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas

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7 January 2021

Molecular predictors of survival after adjuvant chemotherapy for colon cancer

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7 January 2021

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

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7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

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7 January 2021

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

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7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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7 January 2021

Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

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7 January 2021

Microsatellite instability in cancer of the proximal colon

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7 January 2021

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

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7 January 2021

Genetic instability in colorectal cancers

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7 January 2021

Genetic instabilities in human cancers

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7 January 2021

Acceleration of chromosomal instability by loss of BRCA1 expression and p53 abnormality in sporadic breast cancers

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7 January 2021

Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis

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7 January 2021

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

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7 January 2021

Genetic instability of cancer cells is proportional to their degree of aneuploidy

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7 January 2021

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

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7 January 2021

Mutations predisposing to hereditary nonpolyposis colorectal cancer

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7 January 2021

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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7 January 2021

Mutations in the APC tumour suppressor gene cause chromosomal instability

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7 January 2021

Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement.

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7 January 2021

The spindle checkpoint

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7 January 2021

Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer

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7 January 2021

Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers

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7 January 2021

Mutation analysis of mitotic checkpoint genes (hBUB1 and hBUBR1) and microsatellite instability in adult T-cell leukemia/lymphoma

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7 January 2021

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

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7 January 2021

Checkpoints: controls that ensure the order of cell cycle events

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7 January 2021

Replication checkpoint: preventing mitotic catastrophe

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7 January 2021

p53, the cellular gatekeeper for growth and division

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7 January 2021

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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7 January 2021

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 reference

7 January 2021

Feedback control of mitosis in budding yeast

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7 January 2021

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1 reference

7 January 2021

Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint.

1 reference

7 January 2021

CENP-E as an essential component of the mitotic checkpoint in vitro.

1 reference

7 January 2021

Waiting for anaphase: Mad2 and the spindle assembly checkpoint

1 reference

7 January 2021

The anaphase-promoting complex: new subunits and regulators

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7 January 2021

How proteolysis drives the cell cycle

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7 January 2021

Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin

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7 January 2021

Splitting the chromosome: cutting the ties that bind sister chromatids

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7 January 2021

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1 reference

7 January 2021

Mad2-Independent Inhibition of APCCdc20 by the Mitotic Checkpoint Protein BubR1

1 reference

7 January 2021

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

1 reference

7 January 2021

A new view of the spindle checkpoint

1 reference

7 January 2021

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae

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7 January 2021

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1 reference

7 January 2021

Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

1 reference

7 January 2021

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

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7 January 2021

Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis.

1 reference

7 January 2021

Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

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7 January 2021

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

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7 January 2021

Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase

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7 January 2021

Cohesins: chromosomal proteins that prevent premature separation of sister chromatids

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7 January 2021

A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae

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7 January 2021

Cohesion between sister chromatids must be established during DNA replication

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7 January 2021

Separating sister chromatids

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7 January 2021

Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition

1 reference

7 January 2021

Degradation of Drosophila PIM regulates sister chromatid separation during mitosis

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7 January 2021

Securin is required for chromosomal stability in human cells

1 reference

7 January 2021

A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1

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7 January 2021

Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast

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7 January 2021

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

1 reference

7 January 2021

Aneuploid colon cancer cells have a robust spindle checkpoint

1 reference

7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

1 reference

7 January 2021

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1 reference

7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

1 reference

7 January 2021

Correlation of defective mitotic checkpoint with aberrantly reduced expression of MAD2 protein in nasopharyngeal carcinoma cells.

1 reference

7 January 2021

Mitotic checkpoint inactivation fosters transformation in cells lacking the breast cancer susceptibility gene, Brca2.

1 reference

7 January 2021

Killing the umpire: cooperative defects in mitotic checkpoint and BRCA2 genes on the road to transformation

1 reference

7 January 2021

hpttg, a human homologue of rat pttg, is overexpressed in hematopoietic neoplasms. Evidence for a transcriptional activation function of hPTTG

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7 January 2021

hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias

1 reference

7 January 2021

Isolation and characterization of a pituitary tumor-transforming gene (PTTG)

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7 January 2021

Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis

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7 January 2021

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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7 January 2021

Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

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7 January 2021

Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts

1 reference

7 January 2021

Mechanism-based target identification and drug discovery in cancer research

1 reference

7 January 2021

Genetic instability and darwinian selection in tumours

1 reference

7 January 2021

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

1 reference

7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

Use of isogenic human cancer cells for high-throughput screening and drug discovery

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7 January 2021

Carcinogen-specific induction of genetic instability.

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7 January 2021

Identifiers

DOI

10.1038/35101065

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Dimensions Publication ID

31 July 2017

1013162307

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