Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy? (Q34081847)

30 July 2017

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title

Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy? (English)

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30 July 2017

Borea PA

1

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30 July 2017

Dalpiaz A

2

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30 July 2017

Varani K

3

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30 July 2017

Gilli P

4

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30 July 2017

Gilli G

5

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30 July 2017

language of work or name

English

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publication date

1 December 2000

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30 July 2017

Biochemical Pharmacology

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30 July 2017

60

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30 July 2017

1549-1556

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30 July 2017

11

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Binding thermodynamics at A1 and A2A adenosine receptors

30 July 2017

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Full and partial agonistic behaviour and thermodynamic binding parameters of adenosine A1 receptor ligands.

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Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors.

7 January 2021

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Biochemical and pharmacological characterization of periodate-oxidized adenosine analogues at adenosine A1 receptors

7 January 2021

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Thermodynamic in vitro studies as a method to investigate the pharmacodynamic behavior of adenosine A1 receptor ligands.

7 January 2021

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Binding thermodynamics of adenosine A2a receptor ligands

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Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.

7 January 2021

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Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor

7 January 2021

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Thermodynamic analysis of antagonist and agonist interactions with dopamine receptors.

7 January 2021

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Binding thermodynamics of serotonin to rat-brain 5-HT1A, 5HT2A and 5-HT3 receptors

7 January 2021

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Binding thermodynamics of 5-HT1A receptor ligands

7 January 2021

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Thermodynamics of agonist and antagonist interaction with the strychnine-sensitive glycine receptor

7 January 2021

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Differential effects of thiocyanate on the binding thermodynamics of bicuculline methiodide versus SR95531 (gabazine) to the gamma-aminobutyric acid receptor-ionophore complex.

7 January 2021

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Thermodynamics of 5-HT3 receptor binding discriminates agonistic from antagonistic behaviour.

7 January 2021

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Distinct thermodynamic parameters of serotonin 5-HT3 agonists and antagonists to displace [3H]granisetron binding

7 January 2021

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Thermodynamic studies with acetylthiocholine on nicotinic receptors of mammalian skeletal muscle in vitro

7 January 2021

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Thermodynamics of the interaction of d-tubocurarine with nicotinic receptors of mammalian skeletal muscle in vitro.

7 January 2021

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Binding thermodynamics at the human neuronal nicotine receptor.

7 January 2021

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Thermodynamic analysis of binding to the cerebellar type I benzodiazepine receptor

7 January 2021

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Temperature dependence and GABA modulation of beta-carboline binding to rat cerebellum benzodiazepine receptors.

7 January 2021

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

7 January 2021

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LIGAND: A versatile computerized approach for characterization of ligand-binding systems

7 January 2021

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Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC.

7 January 2021

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The thermodynamics of the self-association of the reduced and carboxymethylated form of apoA-II from the human high density lipoprotein complex

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Statistical interpretation of enthalpy–entropy compensation

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Enthalpy-entropy compensation in drug-receptor binding

7 January 2021

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Solvent Reorganization and Thermodynamic Enthalpy-Entropy Compensation

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Do thermodynamic studies provide information on both the binding to and the activation of dopaminergic and other receptors?

7 January 2021

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On the fundamental difference in the thermodynamics of agonist and antagonist interactions with beta-adrenergic receptors and the mechanism of entropy-driven binding

7 January 2021

1 reference

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Temperature-nearly-independent binding constant in several biochemical systems. The underlying entropy-driven binding mechanism and its practical significance

7 January 2021

1 reference

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10.1016/S0006-2952(00)00368-3

7 January 2021

Identifiers

DOI

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30 July 2017

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