Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships (Q34045509)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8096177%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

title

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships (English)

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24 October 2019

1

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24 October 2019

author name string

Ben-Levy R

2

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24 October 2019

Tzahar E

3

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24 October 2019

Liu N

4

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24 October 2019

Wen D

5

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24 October 2019

Yarden Y

6

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24 October 2019

publication date

1 March 1993

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24 October 2019

language of work or name

0 references

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24 October 2019

volume

12

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24 October 2019

issue

3

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24 October 2019

page(s)

961-971

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LIGAND: A versatile computerized approach for characterization of ligand-binding systems

24 October 2019

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

5 July 2018

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erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

5 July 2018

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Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification

5 July 2018

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Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.

5 July 2018

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HER2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor

5 July 2018

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A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation

5 July 2018

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

5 July 2018

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Experimental approaches to hypothetical hormones: detection of a candidate ligand of the neu protooncogene

5 July 2018

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Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2.

5 July 2018

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Signal transduction by receptors with tyrosine kinase activity

5 July 2018

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Induction of a variety of tumors by c-erbB2 and clonal nature of lymphomas even with the mutated gene (Val659----Glu659).

5 July 2018

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Molecular basis of a high affinity murine interleukin-5 receptor

5 July 2018

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The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand.

5 July 2018

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Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

5 July 2018

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p185neu expression in human lung adenocarcinomas predicts shortened survival

5 July 2018

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Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

5 July 2018

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Agonistic antibodies stimulate the kinase encoded by the neu protooncogene in living cells but the oncogenic mutant is constitutively active

5 July 2018

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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

5 July 2018

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5 July 2018

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A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

5 July 2018

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Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

5 July 2018

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5 July 2018

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Characterization of a neu/c-erbB-2 protein-specific activating factor

5 July 2018

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Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

5 July 2018

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A 25 kDa polypeptide is the ligand for p185neu and is secreted by activated macrophages

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Isolation and characterization of a neu protein-specific activating factor from human ATL-2 cell conditioned medium

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Role of alpha beta receptor heterodimer formation in beta platelet-derived growth factor (PDGF) receptor activation by PDGF-AB.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

A dual receptor system is required for basic fibroblast growth factor activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Purification and characterization of the neu/erb B2 ligand-growth factor from bovine kidney

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Identification of heregulin, a specific activator of p185erbB2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells

5 July 2018

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Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses

5 July 2018

1 reference

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Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences

5 July 2018

1 reference

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Morphology, growth, chromosomal pattern and fibrinolytic activity of two new human neuroblastoma cell lines

5 July 2018

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5 July 2018

1 reference

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Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein

28 October 2018

1 reference

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Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=413297

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis

28 October 2018

1 reference

12 December 2020

Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer

1 reference

12 December 2020

Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells

1 reference

12 December 2020

Biochemical analysis of the ligand for the neu oncogenic receptor

1 reference

12 December 2020

10.1002/J.1460-2075.1993.TB05737.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8096177%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8096177%20AND%20SRC:MED&resulttype=core&format=json

24 October 2019

PubMed publication ID

8096177

1 reference