Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock (Q33965313)

30 July 2017

title

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock (English)

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30 July 2017

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Pavel Kovarik

3

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Manuela Baccarini

Manuela Baccarini

5

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Christian Bogdan

Christian Bogdan

9

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David E. Levy

David Levy

11

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Mathias Müller

Mathias Müller

13

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author name string

Marina Karaghiosoff

1

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30 July 2017

Ralf Steinborn

2

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Gernot Kriegshäuser

4

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Birgit Donabauer

6

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Ursula Reichart

7

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Thomas Kolbe

8

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Tomas Leanderson

10

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Thomas Decker

12

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publication date

7 April 2003

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30 July 2017

language of work or name

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volume

4

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issue

5

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page(s)

471-477

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Innate immune sensing and its roots: the story of endotoxin

30 July 2017

cites work

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7 January 2021

Nitric oxide and the immune response

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7 January 2021

Toll receptors, CD14, and macrophage activation and deactivation by LPS.

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7 January 2021

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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7 January 2021

Mammalian Toll-like receptors

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7 January 2021

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

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7 January 2021

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

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7 January 2021

Interferons and their actions

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7 January 2021

IFNs and STATs in innate immunity to microorganisms

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7 January 2021

The function of type I interferons in antimicrobial immunity.

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7 January 2021

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

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7 January 2021

Stats: transcriptional control and biological impact

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7 January 2021

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

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7 January 2021

Partial impairment of cytokine responses in Tyk2-deficient mice

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7 January 2021

Systemic lipopolysaccharide and interleukin-1beta activate the interleukin 6: STAT intracellular signaling pathway in neurons of mouse trigeminal ganglion

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7 January 2021

Treatment with homodimeric interleukin-12 (IL-12) p40 protects mice from IL-12-dependent shock but not from tumor necrosis factor alpha-dependent shock

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7 January 2021

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

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7 January 2021

Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

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7 January 2021

Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

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7 January 2021

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

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7 January 2021

Bacterial induction of beta interferon in mice is a function of the lipopolysaccharide component

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7 January 2021

The interferon system and interferon regulatory factor transcription factors -- studies from gene knockout mice

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7 January 2021

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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7 January 2021

Interferon-β is required for interferon-α production in mouse fibroblasts

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7 January 2021

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

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7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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7 January 2021

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

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7 January 2021

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

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7 January 2021

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death

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7 January 2021

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

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7 January 2021

Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon.

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7 January 2021

Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains

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7 January 2021

Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2.

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7 January 2021

Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity

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7 January 2021

Signaling by toll-like receptor 2 and 4 agonists results in differential gene expression in murine macrophages.

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7 January 2021

p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide

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7 January 2021

Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide

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7 January 2021

Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3

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7 January 2021

IRF3 mediates a TLR3/TLR4-specific antiviral gene program

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7 January 2021

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

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7 January 2021

The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.

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7 January 2021

Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice

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7 January 2021

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice

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7 January 2021

Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling

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7 January 2021

Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection

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7 January 2021

Interferon gamma receptor deficient mice are resistant to endotoxic shock

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7 January 2021

A weak signal for strong responses: interferon-alpha/beta revisited

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7 January 2021

Differential regulation of constitutive major histocompatibility complex class I expression in T and B lymphocytes

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7 January 2021

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

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7 January 2021

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

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7 January 2021

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice

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7 January 2021

Identifiers

DOI

10.1038/NI910

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30 July 2017

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